Chimeric antibody targeting SRPK-1 in the treatment of non-small cell lung cancer by inhibiting growth, migration and invasion

Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in humans, and is characterized by rapid growth, migration, invasion and reoccurrence. Evidence has indicated that the protein and mRNA levels of serine-arginine protein kinase-1 (SRPK-1) are upregulated in NSCLC tissues. H...

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Veröffentlicht in:	Molecular medicine reports 2017-08, Vol.16 (2), p.2121-2127
Hauptverfasser:	Wu, Fan, Li, Jie, Du, Xin, Zhang, Weisan, Lei, Ping, Zhang, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal research Animals Antibodies - immunology Antibodies - pharmacology Antibodies - therapeutic use Arginine Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell growth Cell Line Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects chimeric antibody target for serine-arginine protein kinase-1 Down-Regulation - drug effects Gel electrophoresis Gene expression Genetic aspects Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - metabolism Humans Kinases Laboratories Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphocytes T Male Metastasis Mice Mice, Inbred BALB C Non-small cell lung cancer Non-small cell lung carcinoma Oncolysis oncolytic therapy Phosphorylation Phosphorylation - drug effects Physiological aspects Polymerase chain reaction Protein kinase Protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - immunology Protein-Serine-Threonine Kinases - metabolism Proteins Reverse transcription Risk factors serine-arginine protein kinase-1 Sodium lauryl sulfate Studies target therapy Transcription factors Transplantation, Heterologous β-Catenin
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