A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma

Summary Hepatitis B virus (HBV) genomic mutations A1762T, G1764A and AG1762/1764TA cause production of HBV X protein (HBx) mutants, namely K130M, V131I and KV130/131MI. These mutations are important biomarkers for the development of cirrhosis and hepatocellular carcinoma (HCC) in chronic HBV patient...

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Veröffentlicht in:	Journal of viral hepatitis 2017-12, Vol.24 (12), p.1121-1131
Hauptverfasser:	Siddiqui, Z. I., Farooqui, S. R., Azam, S. A., Afroz, M., Wajid, S., Parveen, S., Kazim, S. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	AG1762/1764TA Cell cycle Cell growth Cell proliferation Cirrhosis Depolarization Fibrosis HBX protein Hepatitis Hepatitis B Hepatitis B virus HBx mutations Hepatocellular carcinoma Intracellular KV130/131MI Liver cancer Liver cirrhosis Mitochondria mitochondrial depolarization Mutation Reactive oxygen species
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