A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans

Multiple genetic variations impact on risk for schizophrenia. Recent analyses by the Psychiatric Genomics Consortium (PGC2) identified 128 SNPs genome-wide associated with the disorder. Furthermore, attention and working memory deficits are core features of schizophrenia, are heritable and have been...

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Veröffentlicht in:	European neuropsychopharmacology 2017-09, Vol.27 (9), p.928-939
Hauptverfasser:	Rampino, Antonio, Taurisano, Paolo, Fanelli, Giuseppe, Attrotto, Mariateresa, Torretta, Silvia, Antonucci, Linda Antonella, Miccolis, Grazia, Pergola, Giulio, Ursini, Gianluca, Maddalena, Giancarlo, Romano, Raffaella, Masellis, Rita, Di Carlo, Pasquale, Pignataro, Patrizia, Blasi, Giuseppe, Bertolino, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Attention Attention - physiology Brain - diagnostic imaging Brain - physiology Brain Mapping Cortex European Continental Ancestry Group - genetics Factor Analysis, Statistical Female Genetic Predisposition to Disease Glutamate Glutamic Acid - metabolism Humans Magnetic Resonance Imaging Male Memory, Short-Term - physiology Multifactorial Inheritance Neuropsychological Tests Polymorphism, Single Nucleotide Prefrontal Schizophrenia Schizophrenia - genetics Schizophrenic Psychology Thinking - physiology Working memory
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