Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence
Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes tha...
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| Veröffentlicht in: | Nature nanotechnology 2017-07, Vol.12 (7), p.692-700 |
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| creator | Xue, Jingwei Zhao, Zekai Zhang, Lei Xue, Lingjing Shen, Shiyang Wen, Yajing Wei, Zhuoyuan Wang, Lu Kong, Lingyi Sun, Hongbin Ping, Qineng Mo, Ran Zhang, Can |
| description | Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.
Neutrophils carrying drug-containing liposomes can suppress recurrence of brain tumours after surgical removal of the tumour. |
| doi_str_mv | 10.1038/nnano.2017.54 |
| format | Article |
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Neutrophils carrying drug-containing liposomes can suppress recurrence of brain tumours after surgical removal of the tumour.</description><identifier>ISSN: 1748-3387</identifier><identifier>EISSN: 1748-3395</identifier><identifier>DOI: 10.1038/nnano.2017.54</identifier><identifier>PMID: 28650441</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/925/352/152 ; 639/925/352/2733 ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Brain ; Brain cancer ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Brain Neoplasms - prevention & control ; Brain tumors ; Cell Line, Tumor ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Glioma ; Glioma - metabolism ; Glioma - pathology ; Glioma - prevention & control ; Glioma cells ; Humans ; Immune system ; Immunosuppressive agents ; Inflammation ; Leukocytes (neutrophilic) ; Liposomes ; Male ; Materials Science ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanotechnology ; Nanotechnology and Microengineering ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - prevention & control ; Neutrophils ; Paclitaxel ; Paclitaxel - chemistry ; Paclitaxel - pharmacokinetics ; Regrowth ; Survival ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Nature nanotechnology, 2017-07, Vol.12 (7), p.692-700</ispartof><rights>Springer Nature Limited 2017</rights><rights>Copyright Nature Publishing Group Jul 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-7fc8a68cc8a750c190f190b1b96aaeb7e58c43911cef54bb3d4250ff1c6c25023</citedby><cites>FETCH-LOGICAL-c426t-7fc8a68cc8a750c190f190b1b96aaeb7e58c43911cef54bb3d4250ff1c6c25023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nnano.2017.54$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nnano.2017.54$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28650441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Jingwei</creatorcontrib><creatorcontrib>Zhao, Zekai</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Xue, Lingjing</creatorcontrib><creatorcontrib>Shen, Shiyang</creatorcontrib><creatorcontrib>Wen, Yajing</creatorcontrib><creatorcontrib>Wei, Zhuoyuan</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Kong, Lingyi</creatorcontrib><creatorcontrib>Sun, Hongbin</creatorcontrib><creatorcontrib>Ping, Qineng</creatorcontrib><creatorcontrib>Mo, Ran</creatorcontrib><creatorcontrib>Zhang, Can</creatorcontrib><title>Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence</title><title>Nature nanotechnology</title><addtitle>Nature Nanotech</addtitle><addtitle>Nat Nanotechnol</addtitle><description>Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.
Neutrophils carrying drug-containing liposomes can suppress recurrence of brain tumours after surgical removal of the tumour.</description><subject>639/925/352/152</subject><subject>639/925/352/2733</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - prevention & control</subject><subject>Brain tumors</subject><subject>Cell Line, Tumor</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Glioma</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Glioma - prevention & control</subject><subject>Glioma cells</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunosuppressive agents</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Liposomes</subject><subject>Male</subject><subject>Materials Science</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Nanotechnology</subject><subject>Nanotechnology and Microengineering</subject><subject>Neoplasm Recurrence, Local - 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Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.
Neutrophils carrying drug-containing liposomes can suppress recurrence of brain tumours after surgical removal of the tumour.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28650441</pmid><doi>10.1038/nnano.2017.54</doi><tpages>9</tpages></addata></record> |
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| subjects | 639/925/352/152 639/925/352/2733 Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Brain Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - prevention & control Brain tumors Cell Line, Tumor Drug delivery Drug delivery systems Drug Delivery Systems - methods Glioma Glioma - metabolism Glioma - pathology Glioma - prevention & control Glioma cells Humans Immune system Immunosuppressive agents Inflammation Leukocytes (neutrophilic) Liposomes Male Materials Science Mice Mice, Inbred BALB C Mice, Nude Nanotechnology Nanotechnology and Microengineering Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Neutrophils Paclitaxel Paclitaxel - chemistry Paclitaxel - pharmacokinetics Regrowth Survival Tumors Xenograft Model Antitumor Assays |
| title | Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence |
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