A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects

Background & Aims Non‐alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, tightly associated with obesity. The histological spectrum of the disease ranges from simple steatosis to steatohepatitis, with different stages of fibrosis, and fibrosis stage is the most significant predic...

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Veröffentlicht in:	Liver international 2018-01, Vol.38 (1), p.155-163
Hauptverfasser:	Giraudi, Pablo J., Gambaro, Sabrina E., Ornelas Arroyo, Sofia, Chackelevicius, Carla M., Giuricin, Michela, Silvestri, Marta, Macor, Daniele, Crocé, Lory S., Bonazza, Deborah, Soardo, Giorgio, Manzini, Nicolò, Zanconati, Fabrizio, Tiribelli, Claudio, Palmisano, Silvia, Rosso, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adult Aged Biomarkers Biomarkers - blood Biopsy Case-Control Studies CD44 antigen Computer Simulation Correlation analysis Diagnosis Diagnostic software Diagnostic systems Enzyme-linked immunosorbent assay Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - blood Fatty liver Female Fibrosis Growth factors Humans in silico strategy Insulin Insulin-like growth factor II Insulin-Like Growth Factor II - analysis Liver Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology Liver diseases liver fibrosis Male Middle Aged morbidly obese Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - etiology Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - diagnosis Osteonectin Predictive Value of Tests Prospective Studies Protein Interaction Maps Proteins Reproducibility of Results Severity of Illness Index Steatosis
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