The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model
Abstract Objective The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. Methods Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mi...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-07, Vol.17 (4), p.561-566 |
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| creator | Wu, Congye Zou, Lei Shi, Shujing Tong, Zhihui Shen, Xiao Yang, Dongliang Ke, Lu Li, Weiqin Li, Jieshou |
| description | Abstract Objective The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. Methods Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments. Severe acute pancreatitis (SAP) model was established by retrograde injection of 0.5% sodium taurocholate (0.1 ml/100 g) from duodenum to pancreatic duct. Histological scores, serum amylase, creatinine, usea nitrogen were compared between WT mice and ApoCIIItg mice. Results Two hundred and sixty-two patients were classified into 4 groups: normal TG (104, 39.7%), mild HTG (72, 27.5%), moderate HTG (47, 17.9%), and severe HTG (39, 14.9%) groups. The proportions of AKI were 13.5% (14/104, normal), 13.9% (10/72, mild), 21.3% (10/47, moderate), and 38.5% (15/39, severe), respectively. After establishing SAP model, the levels of serum amylase ( P |
| doi_str_mv | 10.1016/j.pan.2017.06.006 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1913832276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1424390317305033</els_id><sourcerecordid>1922856324</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-5e4557fbffe2995d6b48494e2df9f0a106b68e2858a06d136f69a822158590c03</originalsourceid><addsrcrecordid>eNp9kk1rFjEQx4Mo9kU_gBcJePHyrJOXze4iCKVYLRR6aD2HPMnEZrtvJrvCfnuzPrVCD4WEyeH3n8x_Zgh5x6BgwNSntpjMUHBgVQGqAFAvyDGTXO5Ew9jLxzeII3KSUgvAOWPNa3LEayWrnOKYTLd3SOPYIR09vVsnjHMMP7vVYgwO-2CoHyM1dpmR3gc34ErD0C5xC3TOWjsuMf1VH6BckY1o5jCHRM3g8s0n9Kaj_eiwe0NeedMlfPsQT8mPi6-35993V9ffLs_PrnZWCjXvSpRlWfm998ibpnRqL2vZSOTONx4MA7VXNfK6rA0ox4TyqjF19lfWZQMWxCn5eMg7xfHXgmnWfUgWu84MOC5Js4aJWnBeqYx-eIK22dSQq8sUz38owWWm2IGycUwpotdTzLbiqhnobRy61dm83sahQek8jqx5_5B52ffoHhX_-p-BzwcAcyt-B4w62YCDRRci2lm7MTyb_ssTte3CEKzp7nHF9N-FTlyDvtn2YVsHVgkoQQjxBzi0rvo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1922856324</pqid></control><display><type>article</type><title>The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model</title><source>Alma/SFX Local Collection</source><creator>Wu, Congye ; Zou, Lei ; Shi, Shujing ; Tong, Zhihui ; Shen, Xiao ; Yang, Dongliang ; Ke, Lu ; Li, Weiqin ; Li, Jieshou</creator><creatorcontrib>Wu, Congye ; Zou, Lei ; Shi, Shujing ; Tong, Zhihui ; Shen, Xiao ; Yang, Dongliang ; Ke, Lu ; Li, Weiqin ; Li, Jieshou</creatorcontrib><description>Abstract Objective The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. Methods Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments. Severe acute pancreatitis (SAP) model was established by retrograde injection of 0.5% sodium taurocholate (0.1 ml/100 g) from duodenum to pancreatic duct. Histological scores, serum amylase, creatinine, usea nitrogen were compared between WT mice and ApoCIIItg mice. Results Two hundred and sixty-two patients were classified into 4 groups: normal TG (104, 39.7%), mild HTG (72, 27.5%), moderate HTG (47, 17.9%), and severe HTG (39, 14.9%) groups. The proportions of AKI were 13.5% (14/104, normal), 13.9% (10/72, mild), 21.3% (10/47, moderate), and 38.5% (15/39, severe), respectively. After establishing SAP model, the levels of serum amylase ( P < 0.05) and pancreatic histological score ( P < 0.05) of ApoCIII-SAP-9h group were significantly higher than that of WT-SAP-9h group, respectively. ApoCIII-SAP-9h group had significantly higher levels of serum creatinine ( P < 0.001), usea nitrogen ( P < 0.001), and kidney histological score ( P < 0.05) than that of WT-SAP-9h group, respectively. Conclusions Mild HTG has little adverse impact on disease severity of acute pancreatitis; severe HTG can aggravate kidney injury in the course of acute pancreatitis. ApoCIII-SAP mice have more serious pancreatic damage and kidney injury than WT-SAP mice.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2017.06.006</identifier><identifier>PMID: 28647101</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Acute kidney injury ; Acute pancreatitis ; Animal model ; Apolipoprotein C-III ; Creatinine ; Duodenum ; Endocrinology & Metabolism ; Gastroenterology and Hepatology ; Hypertriglyceridemia ; Injection ; Kidneys ; Kinases ; Nitrogen ; Pancreas ; Pancreatitis ; Rodents ; SAP protein ; Sodium ; Studies ; Transgenic mice</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2017-07, Vol.17 (4), p.561-566</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier B.V.</rights><rights>Copyright Elsevier Limited Jul-Aug 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-5e4557fbffe2995d6b48494e2df9f0a106b68e2858a06d136f69a822158590c03</citedby><cites>FETCH-LOGICAL-c436t-5e4557fbffe2995d6b48494e2df9f0a106b68e2858a06d136f69a822158590c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28647101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Congye</creatorcontrib><creatorcontrib>Zou, Lei</creatorcontrib><creatorcontrib>Shi, Shujing</creatorcontrib><creatorcontrib>Tong, Zhihui</creatorcontrib><creatorcontrib>Shen, Xiao</creatorcontrib><creatorcontrib>Yang, Dongliang</creatorcontrib><creatorcontrib>Ke, Lu</creatorcontrib><creatorcontrib>Li, Weiqin</creatorcontrib><creatorcontrib>Li, Jieshou</creatorcontrib><title>The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Abstract Objective The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. Methods Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments. Severe acute pancreatitis (SAP) model was established by retrograde injection of 0.5% sodium taurocholate (0.1 ml/100 g) from duodenum to pancreatic duct. Histological scores, serum amylase, creatinine, usea nitrogen were compared between WT mice and ApoCIIItg mice. Results Two hundred and sixty-two patients were classified into 4 groups: normal TG (104, 39.7%), mild HTG (72, 27.5%), moderate HTG (47, 17.9%), and severe HTG (39, 14.9%) groups. The proportions of AKI were 13.5% (14/104, normal), 13.9% (10/72, mild), 21.3% (10/47, moderate), and 38.5% (15/39, severe), respectively. After establishing SAP model, the levels of serum amylase ( P < 0.05) and pancreatic histological score ( P < 0.05) of ApoCIII-SAP-9h group were significantly higher than that of WT-SAP-9h group, respectively. ApoCIII-SAP-9h group had significantly higher levels of serum creatinine ( P < 0.001), usea nitrogen ( P < 0.001), and kidney histological score ( P < 0.05) than that of WT-SAP-9h group, respectively. Conclusions Mild HTG has little adverse impact on disease severity of acute pancreatitis; severe HTG can aggravate kidney injury in the course of acute pancreatitis. ApoCIII-SAP mice have more serious pancreatic damage and kidney injury than WT-SAP mice.</description><subject>Acute kidney injury</subject><subject>Acute pancreatitis</subject><subject>Animal model</subject><subject>Apolipoprotein C-III</subject><subject>Creatinine</subject><subject>Duodenum</subject><subject>Endocrinology & Metabolism</subject><subject>Gastroenterology and Hepatology</subject><subject>Hypertriglyceridemia</subject><subject>Injection</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Nitrogen</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Rodents</subject><subject>SAP protein</subject><subject>Sodium</subject><subject>Studies</subject><subject>Transgenic mice</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kk1rFjEQx4Mo9kU_gBcJePHyrJOXze4iCKVYLRR6aD2HPMnEZrtvJrvCfnuzPrVCD4WEyeH3n8x_Zgh5x6BgwNSntpjMUHBgVQGqAFAvyDGTXO5Ew9jLxzeII3KSUgvAOWPNa3LEayWrnOKYTLd3SOPYIR09vVsnjHMMP7vVYgwO-2CoHyM1dpmR3gc34ErD0C5xC3TOWjsuMf1VH6BckY1o5jCHRM3g8s0n9Kaj_eiwe0NeedMlfPsQT8mPi6-35993V9ffLs_PrnZWCjXvSpRlWfm998ibpnRqL2vZSOTONx4MA7VXNfK6rA0ox4TyqjF19lfWZQMWxCn5eMg7xfHXgmnWfUgWu84MOC5Js4aJWnBeqYx-eIK22dSQq8sUz38owWWm2IGycUwpotdTzLbiqhnobRy61dm83sahQek8jqx5_5B52ffoHhX_-p-BzwcAcyt-B4w62YCDRRci2lm7MTyb_ssTte3CEKzp7nHF9N-FTlyDvtn2YVsHVgkoQQjxBzi0rvo</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Wu, Congye</creator><creator>Zou, Lei</creator><creator>Shi, Shujing</creator><creator>Tong, Zhihui</creator><creator>Shen, Xiao</creator><creator>Yang, Dongliang</creator><creator>Ke, Lu</creator><creator>Li, Weiqin</creator><creator>Li, Jieshou</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model</title><author>Wu, Congye ; Zou, Lei ; Shi, Shujing ; Tong, Zhihui ; Shen, Xiao ; Yang, Dongliang ; Ke, Lu ; Li, Weiqin ; Li, Jieshou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-5e4557fbffe2995d6b48494e2df9f0a106b68e2858a06d136f69a822158590c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute kidney injury</topic><topic>Acute pancreatitis</topic><topic>Animal model</topic><topic>Apolipoprotein C-III</topic><topic>Creatinine</topic><topic>Duodenum</topic><topic>Endocrinology & Metabolism</topic><topic>Gastroenterology and Hepatology</topic><topic>Hypertriglyceridemia</topic><topic>Injection</topic><topic>Kidneys</topic><topic>Kinases</topic><topic>Nitrogen</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Rodents</topic><topic>SAP protein</topic><topic>Sodium</topic><topic>Studies</topic><topic>Transgenic mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Congye</creatorcontrib><creatorcontrib>Zou, Lei</creatorcontrib><creatorcontrib>Shi, Shujing</creatorcontrib><creatorcontrib>Tong, Zhihui</creatorcontrib><creatorcontrib>Shen, Xiao</creatorcontrib><creatorcontrib>Yang, Dongliang</creatorcontrib><creatorcontrib>Ke, Lu</creatorcontrib><creatorcontrib>Li, Weiqin</creatorcontrib><creatorcontrib>Li, Jieshou</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Congye</au><au>Zou, Lei</au><au>Shi, Shujing</au><au>Tong, Zhihui</au><au>Shen, Xiao</au><au>Yang, Dongliang</au><au>Ke, Lu</au><au>Li, Weiqin</au><au>Li, Jieshou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>17</volume><issue>4</issue><spage>561</spage><epage>566</epage><pages>561-566</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Abstract Objective The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. Methods Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments. Severe acute pancreatitis (SAP) model was established by retrograde injection of 0.5% sodium taurocholate (0.1 ml/100 g) from duodenum to pancreatic duct. Histological scores, serum amylase, creatinine, usea nitrogen were compared between WT mice and ApoCIIItg mice. Results Two hundred and sixty-two patients were classified into 4 groups: normal TG (104, 39.7%), mild HTG (72, 27.5%), moderate HTG (47, 17.9%), and severe HTG (39, 14.9%) groups. The proportions of AKI were 13.5% (14/104, normal), 13.9% (10/72, mild), 21.3% (10/47, moderate), and 38.5% (15/39, severe), respectively. After establishing SAP model, the levels of serum amylase ( P < 0.05) and pancreatic histological score ( P < 0.05) of ApoCIII-SAP-9h group were significantly higher than that of WT-SAP-9h group, respectively. ApoCIII-SAP-9h group had significantly higher levels of serum creatinine ( P < 0.001), usea nitrogen ( P < 0.001), and kidney histological score ( P < 0.05) than that of WT-SAP-9h group, respectively. Conclusions Mild HTG has little adverse impact on disease severity of acute pancreatitis; severe HTG can aggravate kidney injury in the course of acute pancreatitis. ApoCIII-SAP mice have more serious pancreatic damage and kidney injury than WT-SAP mice.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>28647101</pmid><doi>10.1016/j.pan.2017.06.006</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2017-07, Vol.17 (4), p.561-566 |
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| subjects | Acute kidney injury Acute pancreatitis Animal model Apolipoprotein C-III Creatinine Duodenum Endocrinology & Metabolism Gastroenterology and Hepatology Hypertriglyceridemia Injection Kidneys Kinases Nitrogen Pancreas Pancreatitis Rodents SAP protein Sodium Studies Transgenic mice |
| title | The role of hypertriglyceridemia for acute kidney injury in the course of acute pancreatitis and an animal model |
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