Progressive Brain Atrophy Despite Persistent Viral Suppression in HIV Patients Older Than 60 Years

BACKGROUND:Current HIV treatments are successful at suppressing plasma HIV RNA to undetectable levels for most adherent patients. Yet, emerging evidence suggests that viral suppression will inadequately control inflammation and mitigate risk for progressive brain injury. We sought to quantify differ...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2017-11, Vol.76 (3), p.289-297
Hauptverfasser:	Clifford, Katherine M, Samboju, Vishal, Cobigo, Yann, Milanini, Benedetta, Marx, Gabriel A, Hellmuth, Joanna M, Rosen, Howard J, Kramer, Joel H, Allen, Isabel E, Valcour, Victor G
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aging AIDS Dementia Complex - pathology AIDS Dementia Complex - virology AIDS/HIV Antiretroviral Therapy, Highly Active Atrophy Atrophy - pathology Brain Brain - pathology Brain injury Brain stem Case-Control Studies CD4 antigen Cerebellum Cognition Cognitive ability Cortex Female Frontal lobe Globus pallidus Head injuries Health risks HIV HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Humans Image processing Magnetic Resonance Imaging Male Medical treatment Middle Aged Morphometry Neuroimaging Patients Ribonucleic acid Risk management RNA Sexually transmitted diseases STD Substantia grisea Sustained Virologic Response Traumatic brain injury Viremia
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