S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model

Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis in the subventricular zone and in the hippocampus after injury. One of the main neurogenic pathways activated by NO is the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway, downstr...

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Veröffentlicht in:	Antioxidants & redox signaling 2018-01, Vol.28 (1), p.15-30
Hauptverfasser:	Santos, Ana Isabel, Carreira, Bruno Pereira, Izquierdo-Álvarez, Alicia, Ramos, Elena, Lourenço, Ana Sofia, Filipa Santos, Daniela, Morte, Maria Inês, Ribeiro, Luís Filipe, Marreiros, Ana, Sánchez-López, Nuria, Marina, Anabel, Carvalho, Caetana Monteiro, Martínez-Ruiz, Antonio, Araújo, Inês Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Cell activation Cell growth Cell Proliferation Cysteine - metabolism Dentate gyrus Disease Models, Animal Epidermal growth factor Extracellular signal-regulated kinase Innovations Kinases MAP kinase MAP Kinase Signaling System - drug effects Mice Neural stem cells Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neurogenesis Neurogenesis - genetics Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxidation-Reduction Phosphorylation Post-translation Protein kinase Protein Processing, Post-Translational Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Ras protein Seizures Seizures - genetics Seizures - metabolism Seizures - physiopathology Serine Signal Transduction Signaling Stem cells Stimulation Subventricular zone
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