NT-proBNP in patients with asymptomatic severe aortic stenosis: relation to coronary microvascular function
In this regard, N-terminal pro-B type natriuretic peptide (NT-proBNP) as well as coronary flow reserve (CFR) has important role in patients who have nonobstructive/normal epicardial coronary arteries (11-17). [...]it has been shown that these two parameters closely negatively correlate (18). The pro...
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| Veröffentlicht in: | Biomarkers in medicine 2017-05, Vol.11 (6), p.409-414 |
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| creator | Banovic, Marko D |
| description | In this regard, N-terminal pro-B type natriuretic peptide (NT-proBNP) as well as coronary flow reserve (CFR) has important role in patients who have nonobstructive/normal epicardial coronary arteries (11-17). [...]it has been shown that these two parameters closely negatively correlate (18). The prognostic value of NT-proBNP has been demonstrated both in symptomatic and asymptomatic AS patients, with moderate and severe AS and with decreased or preserved LVEF (16,26,27). [...]it is not a surprise that NT-proBNP (together with BNP) is the only biomarker mentioned in European Society of Cardiology guidelines (27) in the context of risk stratification in asymptomatic AS patients and possible elective AVR, (level of evidence II B). [...]demonstrating a prognostic value of NT-proBNP to predict symptom onset or future composite adverse events which include AVR is different from predicting alone all-cause or cardiovascular mortality, and it should not be forgotten. In our previous study, NT-proBNP value of 779.00 pg/l was determined as the best cut-off value for the diagnosis of impaired CFR in asymptomatic moderate or severe AS patients with nonobstructed coronary artery (18). [...]NT-proBNP, |
| doi_str_mv | 10.2217/bmm-2017-0083 |
| format | Article |
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[...]it has been shown that these two parameters closely negatively correlate (18). The prognostic value of NT-proBNP has been demonstrated both in symptomatic and asymptomatic AS patients, with moderate and severe AS and with decreased or preserved LVEF (16,26,27). [...]it is not a surprise that NT-proBNP (together with BNP) is the only biomarker mentioned in European Society of Cardiology guidelines (27) in the context of risk stratification in asymptomatic AS patients and possible elective AVR, (level of evidence II B). [...]demonstrating a prognostic value of NT-proBNP to predict symptom onset or future composite adverse events which include AVR is different from predicting alone all-cause or cardiovascular mortality, and it should not be forgotten. In our previous study, NT-proBNP value of 779.00 pg/l was determined as the best cut-off value for the diagnosis of impaired CFR in asymptomatic moderate or severe AS patients with nonobstructed coronary artery (18). [...]NT-proBNP,</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2017-0083</identifier><identifier>PMID: 28644073</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Angina pectoris ; Aortic stenosis ; Aortic Valve Stenosis - metabolism ; Asymptomatic ; Biomarkers ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery ; Coronary Circulation - physiology ; Coronary vessels ; Humans ; Medical prognosis ; Microcirculation - physiology ; microvascular function ; Microvasculature ; Mortality ; Natriuretic Peptide, Brain - metabolism ; natriuretic peptides ; Natriuretic Peptides - metabolism ; Patients ; Peptide Fragments - metabolism ; Peptides ; Stenosis</subject><ispartof>Biomarkers in medicine, 2017-05, Vol.11 (6), p.409-414</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c327t-a2f332aa4348e3dd9ede7013dfbcbf8827d67c8b2797ed3525a0c56deb581abb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28644073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banovic, Marko D</creatorcontrib><title>NT-proBNP in patients with asymptomatic severe aortic stenosis: relation to coronary microvascular function</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>In this regard, N-terminal pro-B type natriuretic peptide (NT-proBNP) as well as coronary flow reserve (CFR) has important role in patients who have nonobstructive/normal epicardial coronary arteries (11-17). [...]it has been shown that these two parameters closely negatively correlate (18). The prognostic value of NT-proBNP has been demonstrated both in symptomatic and asymptomatic AS patients, with moderate and severe AS and with decreased or preserved LVEF (16,26,27). [...]it is not a surprise that NT-proBNP (together with BNP) is the only biomarker mentioned in European Society of Cardiology guidelines (27) in the context of risk stratification in asymptomatic AS patients and possible elective AVR, (level of evidence II B). [...]demonstrating a prognostic value of NT-proBNP to predict symptom onset or future composite adverse events which include AVR is different from predicting alone all-cause or cardiovascular mortality, and it should not be forgotten. In our previous study, NT-proBNP value of 779.00 pg/l was determined as the best cut-off value for the diagnosis of impaired CFR in asymptomatic moderate or severe AS patients with nonobstructed coronary artery (18). [...]NT-proBNP,</description><subject>Angina pectoris</subject><subject>Aortic stenosis</subject><subject>Aortic Valve Stenosis - metabolism</subject><subject>Asymptomatic</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary vessels</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Microcirculation - physiology</subject><subject>microvascular function</subject><subject>Microvasculature</subject><subject>Mortality</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>natriuretic peptides</subject><subject>Natriuretic Peptides - metabolism</subject><subject>Patients</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptides</subject><subject>Stenosis</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtPxSAQhYnR-F66NSRu3FR5tKW4U-MrMepC14TSaURbuAK9xn8v16suTFwxw3yccOYgtEfJEWNUHLfjWDBCRUFIw1fQJhUVKwgXdPW3rvkG2orxhZBKiJqtow3W1GVJBN9Er3ePxSz4s7sHbB2e6WTBpYjfbXrGOn6Ms-THfGlwhDkEwNqHry6B89HGExxgyHPvcPLY-OCdDh94tCb4uY5mGnTA_eTMAtlBa70eIux-n9vo6fLi8fy6uL2_ujk_vS0MZyIVmvWcM61LXjbAu05CB4JQ3vWtafumYaKrhWlaJqSAjles0sRUdQdt1VDdtnwbHS51s7G3CWJSo40GhkE78FNUVFLOpSSlzOjBH_TFT8Hl3ylWEUYlryTLVLGksqsYA_RqFuyYjSpK1CIFlVNQixTUIoXM73-rTu0I3S_9s_YMyCXQT2kKEE3eugG17PILa6yDf8Q_Ae89mGI</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Banovic, Marko D</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>NT-proBNP in patients with asymptomatic severe aortic stenosis: relation to coronary microvascular function</title><author>Banovic, Marko D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-a2f332aa4348e3dd9ede7013dfbcbf8827d67c8b2797ed3525a0c56deb581abb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angina pectoris</topic><topic>Aortic stenosis</topic><topic>Aortic Valve Stenosis - metabolism</topic><topic>Asymptomatic</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coronary artery</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary vessels</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Microcirculation - physiology</topic><topic>microvascular function</topic><topic>Microvasculature</topic><topic>Mortality</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>natriuretic peptides</topic><topic>Natriuretic Peptides - metabolism</topic><topic>Patients</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptides</topic><topic>Stenosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banovic, Marko D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banovic, Marko D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NT-proBNP in patients with asymptomatic severe aortic stenosis: relation to coronary microvascular function</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>11</volume><issue>6</issue><spage>409</spage><epage>414</epage><pages>409-414</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>In this regard, N-terminal pro-B type natriuretic peptide (NT-proBNP) as well as coronary flow reserve (CFR) has important role in patients who have nonobstructive/normal epicardial coronary arteries (11-17). [...]it has been shown that these two parameters closely negatively correlate (18). The prognostic value of NT-proBNP has been demonstrated both in symptomatic and asymptomatic AS patients, with moderate and severe AS and with decreased or preserved LVEF (16,26,27). [...]it is not a surprise that NT-proBNP (together with BNP) is the only biomarker mentioned in European Society of Cardiology guidelines (27) in the context of risk stratification in asymptomatic AS patients and possible elective AVR, (level of evidence II B). [...]demonstrating a prognostic value of NT-proBNP to predict symptom onset or future composite adverse events which include AVR is different from predicting alone all-cause or cardiovascular mortality, and it should not be forgotten. In our previous study, NT-proBNP value of 779.00 pg/l was determined as the best cut-off value for the diagnosis of impaired CFR in asymptomatic moderate or severe AS patients with nonobstructed coronary artery (18). 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| subjects | Angina pectoris Aortic stenosis Aortic Valve Stenosis - metabolism Asymptomatic Biomarkers Cardiovascular disease Cardiovascular diseases Coronary artery Coronary Circulation - physiology Coronary vessels Humans Medical prognosis Microcirculation - physiology microvascular function Microvasculature Mortality Natriuretic Peptide, Brain - metabolism natriuretic peptides Natriuretic Peptides - metabolism Patients Peptide Fragments - metabolism Peptides Stenosis |
| title | NT-proBNP in patients with asymptomatic severe aortic stenosis: relation to coronary microvascular function |
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