Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex

Background: Nicotine and cigarette smoking (CS) are associated with addiction behavior, drug-seeking, and abuse. However, the mechanisms that mediate this association especially, the role of brain-derived neurotrophic factor (BDNF), dopamine (DA), and nuclear factor erythroid 2-related factor 2 (Nrf...

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Veröffentlicht in:	Human & experimental toxicology 2018-05, Vol.37 (5), p.540-556
Hauptverfasser:	Naha, Nibedita, Gandhi, DN, Gautam, AK, Prakash, J Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Ascorbic acid Behavior, Animal - drug effects Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cerebral cortex Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cigarette smoke Cigarette smoking Cognition Cognitive ability Deoxyribonucleic acid Disorders DNA DNA damage Dopamine Dopamine - metabolism Dopamine receptors Drug abuse Drug addiction Drug dosages Hydroxylase Neurodegeneration NF-E2-Related Factor 2 - metabolism Nicotine Nicotine - toxicity Oxidative stress Rats, Wistar Rodents Signal Transduction Signaling Smoke Smoke - adverse effects Smoking Studies Tobacco Tobacco Products Tobacco Smoke Pollution - adverse effects Tobacco smoking Tyrosine Tyrosine 3-monooxygenase
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