From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer that arises from clonal expansion of transformed T-cell precursors. In this review we summarize the current knowledge on the external stimuli and cell-intrinsic lesions that drive aberrant activation of pivotal, pro-tu...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cellular signalling 2017-10, Vol.38, p.10-25
Hauptverfasser:	Oliveira, Mariana L., Akkapeddi, Padma, Alcobia, Isabel, Almeida, Afonso R., Cardoso, Bruno A., Fragoso, Rita, Serafim, Teresa L., Barata, João T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Genetics Humans Interleukin-7 receptor Microenvironment Models, Biological Notch Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Signal Transduction Signaling therapies T-cell acute lymphoblastic leukemia
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!