The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer
Abstract Cancer cells exploit metabolic rearrangements for sustaining their high proliferation rate and energy demand. The TCA cycle is a central metabolic hub necessary for ATP production and for providing precursors used in many biosynthetic pathways. Thus, dysregulation of the TCA cycle flux is f...
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| Veröffentlicht in: | Seminars in cancer biology 2017-12, Vol.47, p.50-56 |
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| container_title | Seminars in cancer biology |
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| creator | Ciccarone, Fabio Vegliante, Rolando Leo, Luca Di Ciriolo, Maria Rosa |
| description | Abstract Cancer cells exploit metabolic rearrangements for sustaining their high proliferation rate and energy demand. The TCA cycle is a central metabolic hub necessary for ATP production and for providing precursors used in many biosynthetic pathways. Thus, dysregulation of the TCA cycle flux is frequently observed in cancer. The identification of mutations in several enzymes of the TCA cycle in human tumours demonstrated a direct connection between this metabolic pathway and cancer occurrence. Moreover, changes in the expression/activity of these enzymes were also shown to promote metabolic adaptation of cancer cells. In this review, the main genetic and non-genetic alterations of TCA cycle in cancer will be described. Particular attention will be given to extrametabolic roles of TCA cycle enzymes and metabolites underlying the regulation of nuclear and mitochondrial DNA transactions. |
| doi_str_mv | 10.1016/j.semcancer.2017.06.008 |
| format | Article |
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The TCA cycle is a central metabolic hub necessary for ATP production and for providing precursors used in many biosynthetic pathways. Thus, dysregulation of the TCA cycle flux is frequently observed in cancer. The identification of mutations in several enzymes of the TCA cycle in human tumours demonstrated a direct connection between this metabolic pathway and cancer occurrence. Moreover, changes in the expression/activity of these enzymes were also shown to promote metabolic adaptation of cancer cells. In this review, the main genetic and non-genetic alterations of TCA cycle in cancer will be described. Particular attention will be given to extrametabolic roles of TCA cycle enzymes and metabolites underlying the regulation of nuclear and mitochondrial DNA transactions.</description><subject>Adenosine Triphosphate - biosynthesis</subject><subject>Animals</subject><subject>Citric Acid Cycle</subject><subject>Energy Metabolism</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Metabolic Networks and Pathways</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>mtDNA</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Oncometabolism</subject><subject>TCA cycle</subject><subject>Transcriptional Activation</subject><issn>1044-579X</issn><issn>1096-3650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EoqXlL4CPXBL8EX_kgrRaPqWqPbCVuFnOZAJeEqfYWdD-exxt6YFTT-OR3ved8TOEvOas5ozrt_s64wQ-AqZaMG5qpmvG7BNyzlmrK6kVe7q-m6ZSpv12Rl7kvGeMtQ1vnpMzYXWjNDPn5Gb3A-luu6FwhBGpz9TTLoX-O9IOlz-Ikc4R5gkX381jyBP1safvrzd0ST5mD0uYY6Yh0tM2l-TZ4MeML-_rBbn9-GG3_Vxd3Xz6st1cVaAavlQSB931Rmkh_GCFsUoaodADF9q0rRbWAwBTHqzhvdYdGNOI0thB2tYKeUHenHLv0vzrgHlxU8iA4-gjzofseMulbLVVrEjNSQppzjnh4O5SmHw6Os7cStPt3QNNt9J0TLtCszhf3Q85dBP2D75_-IpgcxJg-ervUOwZApacPiSExfVzeMSQd_9lwBhiAD_-xCPm_XxIsZB03GXhmPu6HnW9KTeyxDZK_gWiQZ2f</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Ciccarone, Fabio</creator><creator>Vegliante, Rolando</creator><creator>Leo, Luca Di</creator><creator>Ciriolo, Maria Rosa</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer</title><author>Ciccarone, Fabio ; Vegliante, Rolando ; Leo, Luca Di ; Ciriolo, Maria Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-3ef6bd75622af827853725eac126799628accc05ac871d66bc7742c878f389823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosine Triphosphate - biosynthesis</topic><topic>Animals</topic><topic>Citric Acid Cycle</topic><topic>Energy Metabolism</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Metabolic Networks and Pathways</topic><topic>Mitochondria - genetics</topic><topic>Mitochondria - metabolism</topic><topic>mtDNA</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Oncometabolism</topic><topic>TCA cycle</topic><topic>Transcriptional Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciccarone, Fabio</creatorcontrib><creatorcontrib>Vegliante, Rolando</creatorcontrib><creatorcontrib>Leo, Luca Di</creatorcontrib><creatorcontrib>Ciriolo, Maria Rosa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cancer biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciccarone, Fabio</au><au>Vegliante, Rolando</au><au>Leo, Luca Di</au><au>Ciriolo, Maria Rosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer</atitle><jtitle>Seminars in cancer biology</jtitle><addtitle>Semin Cancer Biol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>47</volume><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>1044-579X</issn><eissn>1096-3650</eissn><abstract>Abstract Cancer cells exploit metabolic rearrangements for sustaining their high proliferation rate and energy demand. 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| subjects | Adenosine Triphosphate - biosynthesis Animals Citric Acid Cycle Energy Metabolism Epigenesis, Genetic Epigenetics Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Metabolic Networks and Pathways Mitochondria - genetics Mitochondria - metabolism mtDNA Neoplasms - genetics Neoplasms - metabolism Oncometabolism TCA cycle Transcriptional Activation |
| title | The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer |
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