Digenic inheritance of mutations in the cardiac troponin ( TNNT2 ) and cardiac beta myosin heavy chain ( MYH7 ) as the cause of severe dilated cardiomyopathy

Abstract Familial dilated cardiomyopathy (DCM) is characterized by ventricular dilation and depressed myocardial performance. It is a genetically heterogeneous disorder associated with mutations in over 60 genes. We carried out whole exome sequencing in combination with cardiomyopathy-related gene-f...

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