Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children
Obesity in childhood and adolescence is associated with metabolic syndrome and cardiovascular diseases. TRB3 (Tribbles homolog 3) and sestrin 2 are two newly found proteins that have been identified to play an important role in obesity and its complications. The purpose of this study was to evaluate...
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| Veröffentlicht in: | Childhood obesity 2017-10, Vol.13 (5), p.409-414 |
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| creator | Nourbakhsh, Mitra Sharifi, Roya Ghorbanhosseini, Seyedeh Sara Javad, Ali Ahmadpour, Fatemeh Razzaghy Azar, Maryam Larijani, Bagher |
| description | Obesity in childhood and adolescence is associated with metabolic syndrome and cardiovascular diseases. TRB3 (Tribbles homolog 3) and sestrin 2 are two newly found proteins that have been identified to play an important role in obesity and its complications.
The purpose of this study was to evaluate concentrations of TRB3 and sestrin 2 in plasma of obese and normal-weight children and adolescents, and their association with metabolic and anthropometric parameters.
Plasma levels of TRB3, sestrin 2, insulin, fasting plasma glucose (FPG), and lipid profile were evaluated in 70 children and adolescents (34 obese and 36 controls). Insulin resistance was calculated using a homeostasis model assessment of insulin resistance. Metabolic syndrome was defined according to IDF criteria.
Plasma TRB3 levels of the obese subjects were significantly higher than that of normal weight subjects. TRB3 levels were positively correlated with BMI, BMI z-score, waist circumference, and FPG. The concentration of sestrin 2 was significantly lower in obese subjects compared to normal-weight subjects. A statistically significant positive correlation was observed between plasma concentrations of sestrin 2 and high-density lipoprotein cholesterol. Neither TRB3 nor sestrin 2 were correlated with insulin resistance and metabolic syndrome.
Both TRB3 and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity. |
| doi_str_mv | 10.1089/chi.2017.0082 |
| format | Article |
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The purpose of this study was to evaluate concentrations of TRB3 and sestrin 2 in plasma of obese and normal-weight children and adolescents, and their association with metabolic and anthropometric parameters.
Plasma levels of TRB3, sestrin 2, insulin, fasting plasma glucose (FPG), and lipid profile were evaluated in 70 children and adolescents (34 obese and 36 controls). Insulin resistance was calculated using a homeostasis model assessment of insulin resistance. Metabolic syndrome was defined according to IDF criteria.
Plasma TRB3 levels of the obese subjects were significantly higher than that of normal weight subjects. TRB3 levels were positively correlated with BMI, BMI z-score, waist circumference, and FPG. The concentration of sestrin 2 was significantly lower in obese subjects compared to normal-weight subjects. A statistically significant positive correlation was observed between plasma concentrations of sestrin 2 and high-density lipoprotein cholesterol. Neither TRB3 nor sestrin 2 were correlated with insulin resistance and metabolic syndrome.
Both TRB3 and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity.</description><identifier>ISSN: 2153-2168</identifier><identifier>EISSN: 2153-2176</identifier><identifier>DOI: 10.1089/chi.2017.0082</identifier><identifier>PMID: 28639842</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Age ; Biochemistry ; Blood Glucose - analysis ; Blood pressure ; Body Mass Index ; Cell Cycle Proteins - blood ; Child ; Cholesterol, HDL - blood ; Diabetes ; Endocrinology ; Exercise ; Fasting ; Female ; Glucose ; Homeostasis ; Humans ; Hyperglycemia ; Insects ; Insulin - blood ; Insulin Resistance ; Kinases ; Lipids - blood ; Liver diseases ; Male ; Mammals ; Medical laboratories ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolites ; Nuclear Proteins - blood ; Obesity ; Oxidative stress ; Pediatric Obesity - blood ; Physical fitness ; Protein-Serine-Threonine Kinases - antagonists & inhibitors ; Protein-Serine-Threonine Kinases - blood ; Proteins ; Repressor Proteins - blood ; Research centers ; Rodents ; Teenagers ; Waist Circumference</subject><ispartof>Childhood obesity, 2017-10, Vol.13 (5), p.409-414</ispartof><rights>(©) Copyright 2017, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-928bffdd3649e0d62ac2b66c96389421ee0bb18f03d472429982ac14156d6c933</citedby><cites>FETCH-LOGICAL-c321t-928bffdd3649e0d62ac2b66c96389421ee0bb18f03d472429982ac14156d6c933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28639842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nourbakhsh, Mitra</creatorcontrib><creatorcontrib>Sharifi, Roya</creatorcontrib><creatorcontrib>Ghorbanhosseini, Seyedeh Sara</creatorcontrib><creatorcontrib>Javad, Ali</creatorcontrib><creatorcontrib>Ahmadpour, Fatemeh</creatorcontrib><creatorcontrib>Razzaghy Azar, Maryam</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><title>Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children</title><title>Childhood obesity</title><addtitle>Child Obes</addtitle><description>Obesity in childhood and adolescence is associated with metabolic syndrome and cardiovascular diseases. TRB3 (Tribbles homolog 3) and sestrin 2 are two newly found proteins that have been identified to play an important role in obesity and its complications.
The purpose of this study was to evaluate concentrations of TRB3 and sestrin 2 in plasma of obese and normal-weight children and adolescents, and their association with metabolic and anthropometric parameters.
Plasma levels of TRB3, sestrin 2, insulin, fasting plasma glucose (FPG), and lipid profile were evaluated in 70 children and adolescents (34 obese and 36 controls). Insulin resistance was calculated using a homeostasis model assessment of insulin resistance. Metabolic syndrome was defined according to IDF criteria.
Plasma TRB3 levels of the obese subjects were significantly higher than that of normal weight subjects. TRB3 levels were positively correlated with BMI, BMI z-score, waist circumference, and FPG. The concentration of sestrin 2 was significantly lower in obese subjects compared to normal-weight subjects. A statistically significant positive correlation was observed between plasma concentrations of sestrin 2 and high-density lipoprotein cholesterol. Neither TRB3 nor sestrin 2 were correlated with insulin resistance and metabolic syndrome.
Both TRB3 and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity.</description><subject>Adolescent</subject><subject>Age</subject><subject>Biochemistry</subject><subject>Blood Glucose - analysis</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>Cell Cycle Proteins - blood</subject><subject>Child</subject><subject>Cholesterol, HDL - blood</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insects</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Kinases</subject><subject>Lipids - blood</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Mammals</subject><subject>Medical laboratories</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolites</subject><subject>Nuclear Proteins - blood</subject><subject>Obesity</subject><subject>Oxidative stress</subject><subject>Pediatric Obesity - blood</subject><subject>Physical fitness</subject><subject>Protein-Serine-Threonine Kinases - antagonists & inhibitors</subject><subject>Protein-Serine-Threonine Kinases - blood</subject><subject>Proteins</subject><subject>Repressor Proteins - blood</subject><subject>Research centers</subject><subject>Rodents</subject><subject>Teenagers</subject><subject>Waist Circumference</subject><issn>2153-2168</issn><issn>2153-2176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEtLAzEURoMottQu3UrAjZupeU0mWWqpDyhWasVlyEwydso8ajJT8N-bsbUL7-Z-cA8flwPAJUYTjIS8zdbFhCCcTBAS5AQMCY5pRHDCT4-ZiwEYe79BYaikGMlzMCCCUykYGYLlbKfLTrdFU8Mmh6-l9pWGq-U9hbo28M361hU1JHBud7b0MORFar39vb40rtJl9GGLz3ULp-uiNM7WF-As16W348MegfeH2Wr6FM0Xj8_Tu3mUUYLbSBKR5rkxlDNpkeFEZyTlPJOcCskIthalKRY5ooYlhBEpRUAwwzE3gaJ0BG72vVvXfHXhUVUVPrNlqWvbdF5hiQnHPBY9ev0P3TSdq8N3gWKEYsGSOFDRnspc472zudq6otLuW2Gket8q-Fa9b9X7DvzVobVLK2uO9J9d-gNyCHe2</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Nourbakhsh, Mitra</creator><creator>Sharifi, Roya</creator><creator>Ghorbanhosseini, Seyedeh Sara</creator><creator>Javad, Ali</creator><creator>Ahmadpour, Fatemeh</creator><creator>Razzaghy Azar, Maryam</creator><creator>Larijani, Bagher</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children</title><author>Nourbakhsh, Mitra ; Sharifi, Roya ; Ghorbanhosseini, Seyedeh Sara ; Javad, Ali ; Ahmadpour, Fatemeh ; Razzaghy Azar, Maryam ; Larijani, Bagher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-928bffdd3649e0d62ac2b66c96389421ee0bb18f03d472429982ac14156d6c933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Biochemistry</topic><topic>Blood Glucose - analysis</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>Cell Cycle Proteins - blood</topic><topic>Child</topic><topic>Cholesterol, HDL - blood</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Exercise</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insects</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Kinases</topic><topic>Lipids - blood</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Mammals</topic><topic>Medical laboratories</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolites</topic><topic>Nuclear Proteins - blood</topic><topic>Obesity</topic><topic>Oxidative stress</topic><topic>Pediatric Obesity - blood</topic><topic>Physical fitness</topic><topic>Protein-Serine-Threonine Kinases - antagonists & inhibitors</topic><topic>Protein-Serine-Threonine Kinases - blood</topic><topic>Proteins</topic><topic>Repressor Proteins - blood</topic><topic>Research centers</topic><topic>Rodents</topic><topic>Teenagers</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nourbakhsh, Mitra</creatorcontrib><creatorcontrib>Sharifi, Roya</creatorcontrib><creatorcontrib>Ghorbanhosseini, Seyedeh Sara</creatorcontrib><creatorcontrib>Javad, Ali</creatorcontrib><creatorcontrib>Ahmadpour, Fatemeh</creatorcontrib><creatorcontrib>Razzaghy Azar, Maryam</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Childhood obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nourbakhsh, Mitra</au><au>Sharifi, Roya</au><au>Ghorbanhosseini, Seyedeh Sara</au><au>Javad, Ali</au><au>Ahmadpour, Fatemeh</au><au>Razzaghy Azar, Maryam</au><au>Larijani, Bagher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children</atitle><jtitle>Childhood obesity</jtitle><addtitle>Child Obes</addtitle><date>2017-10</date><risdate>2017</risdate><volume>13</volume><issue>5</issue><spage>409</spage><epage>414</epage><pages>409-414</pages><issn>2153-2168</issn><eissn>2153-2176</eissn><abstract>Obesity in childhood and adolescence is associated with metabolic syndrome and cardiovascular diseases. TRB3 (Tribbles homolog 3) and sestrin 2 are two newly found proteins that have been identified to play an important role in obesity and its complications.
The purpose of this study was to evaluate concentrations of TRB3 and sestrin 2 in plasma of obese and normal-weight children and adolescents, and their association with metabolic and anthropometric parameters.
Plasma levels of TRB3, sestrin 2, insulin, fasting plasma glucose (FPG), and lipid profile were evaluated in 70 children and adolescents (34 obese and 36 controls). Insulin resistance was calculated using a homeostasis model assessment of insulin resistance. Metabolic syndrome was defined according to IDF criteria.
Plasma TRB3 levels of the obese subjects were significantly higher than that of normal weight subjects. TRB3 levels were positively correlated with BMI, BMI z-score, waist circumference, and FPG. The concentration of sestrin 2 was significantly lower in obese subjects compared to normal-weight subjects. A statistically significant positive correlation was observed between plasma concentrations of sestrin 2 and high-density lipoprotein cholesterol. Neither TRB3 nor sestrin 2 were correlated with insulin resistance and metabolic syndrome.
Both TRB3 and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>28639842</pmid><doi>10.1089/chi.2017.0082</doi><tpages>6</tpages></addata></record> |
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| ispartof | Childhood obesity, 2017-10, Vol.13 (5), p.409-414 |
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| subjects | Adolescent Age Biochemistry Blood Glucose - analysis Blood pressure Body Mass Index Cell Cycle Proteins - blood Child Cholesterol, HDL - blood Diabetes Endocrinology Exercise Fasting Female Glucose Homeostasis Humans Hyperglycemia Insects Insulin - blood Insulin Resistance Kinases Lipids - blood Liver diseases Male Mammals Medical laboratories Metabolic disorders Metabolic syndrome Metabolic Syndrome - blood Metabolites Nuclear Proteins - blood Obesity Oxidative stress Pediatric Obesity - blood Physical fitness Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - blood Proteins Repressor Proteins - blood Research centers Rodents Teenagers Waist Circumference |
| title | Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and Normal-Weight Children |
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