Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry
Purpose Chronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inf...
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| Veröffentlicht in: | Endocrine 2017-08, Vol.57 (2), p.298-307 |
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| creator | Grotevendt, A. Wallaschofski, H. Reincke, M. Adolf, C. Quinkler, M. Nauck, M. Hoffmann, W. Rettig, R. Hannemann, A. |
| description | Purpose
Chronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inflammatory biomarker concentrations in healthy, normotensive subjects and patients with primary aldosteronism.
Methods
We included 1177 normotensive individuals from the population-based Study of Health in Pomerania (first follow-up, Study of Health in Pomerania-1) and 103 primary aldosteronism patients from the German Conn’s Registry. A 1:1 matching for sex, age, body mass index, smoking status, diabetes mellitus, and the estimated glomerular filtration rate was performed to determine whether primary aldosteronism patients exhibit higher inflammatory biomarker concentrations than normotensive controls. The associations of plasma aldosterone concentration or plasma renin concentration with circulating fibrinogen concentrations, white blood cell count, and high sensitive C-reactive protein concentrations in the normotensive sample were determined with multivariable linear and logistic regression analyses.
Results
1:1 matched primary aldosteronism patients demonstrated significantly (
p
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| doi_str_mv | 10.1007/s12020-017-1348-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1912615912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1912615912</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8baefdc5c8a648f0860c48107476538204c01410085a143eccafbec397e81b4d3</originalsourceid><addsrcrecordid>eNp1kc9q3DAQxkVJaNK0D9BLEeSSi5ORLNvyMSzNHwikJCn0JrTyOFGwpVSSKXvruede-np9ksi721IKuUhi9Pu-GeYj5D2DYwbQnETGgUMBrClYKWQhX5F9VlVtrgDs5HdZVQWA_LJH3sT4CMA5r5vXZI_LupStFPvkx2mM3lidrHeR-p7qofMxYfAOqXYdDeiso8Y7gy6FLffNpgdqXT_ocVyXfn__mR6Q3qapW80uF6iHNUI_-RGDdlav3WboHMOoHV14l2W_Ir3BextTWL0lu70eIr7b3gfk89nHu8VFcXV9frk4vSpM2fBUyKXGvjOVkboWsgdZgxGSQSOauiolB2GAibwAWWkmSjRG90s0ZdugZEvRlQfkaOP7FPzXCWNSo40Gh0E79FNUrGW8ZlU-M3r4H_rop-DydDOViZaxJlNsQ5ngYwzYq6dgRx1WioGag1KboFQOSs1BKZk1H7bO03LE7q_iTzIZ4Bsg5i93j-Gf1i-6PgOL2KE1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1919129117</pqid></control><display><type>article</type><title>Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Grotevendt, A. ; Wallaschofski, H. ; Reincke, M. ; Adolf, C. ; Quinkler, M. ; Nauck, M. ; Hoffmann, W. ; Rettig, R. ; Hannemann, A.</creator><creatorcontrib>Grotevendt, A. ; Wallaschofski, H. ; Reincke, M. ; Adolf, C. ; Quinkler, M. ; Nauck, M. ; Hoffmann, W. ; Rettig, R. ; Hannemann, A.</creatorcontrib><description>Purpose
Chronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inflammatory biomarker concentrations in healthy, normotensive subjects and patients with primary aldosteronism.
Methods
We included 1177 normotensive individuals from the population-based Study of Health in Pomerania (first follow-up, Study of Health in Pomerania-1) and 103 primary aldosteronism patients from the German Conn’s Registry. A 1:1 matching for sex, age, body mass index, smoking status, diabetes mellitus, and the estimated glomerular filtration rate was performed to determine whether primary aldosteronism patients exhibit higher inflammatory biomarker concentrations than normotensive controls. The associations of plasma aldosterone concentration or plasma renin concentration with circulating fibrinogen concentrations, white blood cell count, and high sensitive C-reactive protein concentrations in the normotensive sample were determined with multivariable linear and logistic regression analyses.
Results
1:1 matched primary aldosteronism patients demonstrated significantly (
p
< 0.01) higher plasma aldosterone concentration (198 vs. 47 ng/l), lower plasma renin concentration (3.1 vs. 7.7 ng/l) and higher high sensitive C-reactive protein concentrations (1.5 vs. 1.0 mg/l) than normotensive controls. Within the normotensive cohort, plasma renin concentration but not plasma aldosterone concentration was positively associated with fibrinogen concentrations and white blood cell count. Further, a J-shaped association between plasma renin concentration and high sensitive C-reactive protein concentrations was detected.
Conclusions
High plasma aldosterone concentration in a primary aldosteronism cohort and high plasma renin concentration in normotensive subjects are associated with increased concentrations of inflammatory biomarkers. This suggests a link between the renin-angiotensin-aldosterone system and inflammatory processes in patients with primary aldosteronism and even in normotensive subjects.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-017-1348-8</identifier><identifier>PMID: 28638984</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Age ; Aldosterone ; Aldosterone - blood ; Angiotensin ; Biomarkers - blood ; Blood pressure ; Body mass ; Body mass index ; C-reactive protein ; C-Reactive Protein - analysis ; Cohort Studies ; Diabetes ; Diabetes mellitus ; Endocrine disorders ; Endocrinology ; Female ; Fibrinogen ; Fibrinogen - analysis ; Germany - epidemiology ; Glomerular filtration rate ; Humanities and Social Sciences ; Humans ; Hyperaldosteronism - blood ; Hyperaldosteronism - epidemiology ; Inflammation ; Inflammation - blood ; Inflammation - epidemiology ; Internal Medicine ; Leukocyte Count ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Morbidity ; multidisciplinary ; Original Article ; Population ; Population studies ; Population-based studies ; Proteins ; Reference Values ; Registries ; Renin ; Renin - blood ; Science ; Smoking ; Socioeconomic Factors</subject><ispartof>Endocrine, 2017-08, Vol.57 (2), p.298-307</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8baefdc5c8a648f0860c48107476538204c01410085a143eccafbec397e81b4d3</citedby><cites>FETCH-LOGICAL-c372t-8baefdc5c8a648f0860c48107476538204c01410085a143eccafbec397e81b4d3</cites><orcidid>0000-0003-4420-5449</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-017-1348-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-017-1348-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28638984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grotevendt, A.</creatorcontrib><creatorcontrib>Wallaschofski, H.</creatorcontrib><creatorcontrib>Reincke, M.</creatorcontrib><creatorcontrib>Adolf, C.</creatorcontrib><creatorcontrib>Quinkler, M.</creatorcontrib><creatorcontrib>Nauck, M.</creatorcontrib><creatorcontrib>Hoffmann, W.</creatorcontrib><creatorcontrib>Rettig, R.</creatorcontrib><creatorcontrib>Hannemann, A.</creatorcontrib><title>Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
Chronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inflammatory biomarker concentrations in healthy, normotensive subjects and patients with primary aldosteronism.
Methods
We included 1177 normotensive individuals from the population-based Study of Health in Pomerania (first follow-up, Study of Health in Pomerania-1) and 103 primary aldosteronism patients from the German Conn’s Registry. A 1:1 matching for sex, age, body mass index, smoking status, diabetes mellitus, and the estimated glomerular filtration rate was performed to determine whether primary aldosteronism patients exhibit higher inflammatory biomarker concentrations than normotensive controls. The associations of plasma aldosterone concentration or plasma renin concentration with circulating fibrinogen concentrations, white blood cell count, and high sensitive C-reactive protein concentrations in the normotensive sample were determined with multivariable linear and logistic regression analyses.
Results
1:1 matched primary aldosteronism patients demonstrated significantly (
p
< 0.01) higher plasma aldosterone concentration (198 vs. 47 ng/l), lower plasma renin concentration (3.1 vs. 7.7 ng/l) and higher high sensitive C-reactive protein concentrations (1.5 vs. 1.0 mg/l) than normotensive controls. Within the normotensive cohort, plasma renin concentration but not plasma aldosterone concentration was positively associated with fibrinogen concentrations and white blood cell count. Further, a J-shaped association between plasma renin concentration and high sensitive C-reactive protein concentrations was detected.
Conclusions
High plasma aldosterone concentration in a primary aldosteronism cohort and high plasma renin concentration in normotensive subjects are associated with increased concentrations of inflammatory biomarkers. This suggests a link between the renin-angiotensin-aldosterone system and inflammatory processes in patients with primary aldosteronism and even in normotensive subjects.</description><subject>Adult</subject><subject>Age</subject><subject>Aldosterone</subject><subject>Aldosterone - blood</subject><subject>Angiotensin</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Endocrine disorders</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinogen - analysis</subject><subject>Germany - epidemiology</subject><subject>Glomerular filtration rate</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperaldosteronism - blood</subject><subject>Hyperaldosteronism - epidemiology</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - epidemiology</subject><subject>Internal Medicine</subject><subject>Leukocyte Count</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Proteins</subject><subject>Reference Values</subject><subject>Registries</subject><subject>Renin</subject><subject>Renin - blood</subject><subject>Science</subject><subject>Smoking</subject><subject>Socioeconomic Factors</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9q3DAQxkVJaNK0D9BLEeSSi5ORLNvyMSzNHwikJCn0JrTyOFGwpVSSKXvruede-np9ksi721IKuUhi9Pu-GeYj5D2DYwbQnETGgUMBrClYKWQhX5F9VlVtrgDs5HdZVQWA_LJH3sT4CMA5r5vXZI_LupStFPvkx2mM3lidrHeR-p7qofMxYfAOqXYdDeiso8Y7gy6FLffNpgdqXT_ocVyXfn__mR6Q3qapW80uF6iHNUI_-RGDdlav3WboHMOoHV14l2W_Ir3BextTWL0lu70eIr7b3gfk89nHu8VFcXV9frk4vSpM2fBUyKXGvjOVkboWsgdZgxGSQSOauiolB2GAibwAWWkmSjRG90s0ZdugZEvRlQfkaOP7FPzXCWNSo40Gh0E79FNUrGW8ZlU-M3r4H_rop-DydDOViZaxJlNsQ5ngYwzYq6dgRx1WioGag1KboFQOSs1BKZk1H7bO03LE7q_iTzIZ4Bsg5i93j-Gf1i-6PgOL2KE1</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Grotevendt, A.</creator><creator>Wallaschofski, H.</creator><creator>Reincke, M.</creator><creator>Adolf, C.</creator><creator>Quinkler, M.</creator><creator>Nauck, M.</creator><creator>Hoffmann, W.</creator><creator>Rettig, R.</creator><creator>Hannemann, A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4420-5449</orcidid></search><sort><creationdate>20170801</creationdate><title>Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry</title><author>Grotevendt, A. ; Wallaschofski, H. ; Reincke, M. ; Adolf, C. ; Quinkler, M. ; Nauck, M. ; Hoffmann, W. ; Rettig, R. ; Hannemann, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8baefdc5c8a648f0860c48107476538204c01410085a143eccafbec397e81b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aldosterone</topic><topic>Aldosterone - blood</topic><topic>Angiotensin</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Endocrine disorders</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinogen - analysis</topic><topic>Germany - epidemiology</topic><topic>Glomerular filtration rate</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperaldosteronism - blood</topic><topic>Hyperaldosteronism - epidemiology</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - epidemiology</topic><topic>Internal Medicine</topic><topic>Leukocyte Count</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Proteins</topic><topic>Reference Values</topic><topic>Registries</topic><topic>Renin</topic><topic>Renin - blood</topic><topic>Science</topic><topic>Smoking</topic><topic>Socioeconomic Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grotevendt, A.</creatorcontrib><creatorcontrib>Wallaschofski, H.</creatorcontrib><creatorcontrib>Reincke, M.</creatorcontrib><creatorcontrib>Adolf, C.</creatorcontrib><creatorcontrib>Quinkler, M.</creatorcontrib><creatorcontrib>Nauck, M.</creatorcontrib><creatorcontrib>Hoffmann, W.</creatorcontrib><creatorcontrib>Rettig, R.</creatorcontrib><creatorcontrib>Hannemann, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grotevendt, A.</au><au>Wallaschofski, H.</au><au>Reincke, M.</au><au>Adolf, C.</au><au>Quinkler, M.</au><au>Nauck, M.</au><au>Hoffmann, W.</au><au>Rettig, R.</au><au>Hannemann, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>57</volume><issue>2</issue><spage>298</spage><epage>307</epage><pages>298-307</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
Chronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inflammatory biomarker concentrations in healthy, normotensive subjects and patients with primary aldosteronism.
Methods
We included 1177 normotensive individuals from the population-based Study of Health in Pomerania (first follow-up, Study of Health in Pomerania-1) and 103 primary aldosteronism patients from the German Conn’s Registry. A 1:1 matching for sex, age, body mass index, smoking status, diabetes mellitus, and the estimated glomerular filtration rate was performed to determine whether primary aldosteronism patients exhibit higher inflammatory biomarker concentrations than normotensive controls. The associations of plasma aldosterone concentration or plasma renin concentration with circulating fibrinogen concentrations, white blood cell count, and high sensitive C-reactive protein concentrations in the normotensive sample were determined with multivariable linear and logistic regression analyses.
Results
1:1 matched primary aldosteronism patients demonstrated significantly (
p
< 0.01) higher plasma aldosterone concentration (198 vs. 47 ng/l), lower plasma renin concentration (3.1 vs. 7.7 ng/l) and higher high sensitive C-reactive protein concentrations (1.5 vs. 1.0 mg/l) than normotensive controls. Within the normotensive cohort, plasma renin concentration but not plasma aldosterone concentration was positively associated with fibrinogen concentrations and white blood cell count. Further, a J-shaped association between plasma renin concentration and high sensitive C-reactive protein concentrations was detected.
Conclusions
High plasma aldosterone concentration in a primary aldosteronism cohort and high plasma renin concentration in normotensive subjects are associated with increased concentrations of inflammatory biomarkers. This suggests a link between the renin-angiotensin-aldosterone system and inflammatory processes in patients with primary aldosteronism and even in normotensive subjects.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28638984</pmid><doi>10.1007/s12020-017-1348-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4420-5449</orcidid></addata></record> |
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| subjects | Adult Age Aldosterone Aldosterone - blood Angiotensin Biomarkers - blood Blood pressure Body mass Body mass index C-reactive protein C-Reactive Protein - analysis Cohort Studies Diabetes Diabetes mellitus Endocrine disorders Endocrinology Female Fibrinogen Fibrinogen - analysis Germany - epidemiology Glomerular filtration rate Humanities and Social Sciences Humans Hyperaldosteronism - blood Hyperaldosteronism - epidemiology Inflammation Inflammation - blood Inflammation - epidemiology Internal Medicine Leukocyte Count Longitudinal Studies Male Medicine Medicine & Public Health Middle Aged Morbidity multidisciplinary Original Article Population Population studies Population-based studies Proteins Reference Values Registries Renin Renin - blood Science Smoking Socioeconomic Factors |
| title | Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry |
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