Tandem In Situ Monitoring for Quantitative Assessment of Mechanochemical Reactions Involving Structurally Unknown Phases

We report herein quantitative in situ monitoring by simultaneous PXRD and Raman spectroscopy of the mechanochemical reaction between benzoic acid and nicotinamide, affording a rich polymorphic system with four new cocrystal polymorphs, multiple phase transformations, and a variety of reaction pathwa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry : a European journal 2017-10, Vol.23 (56), p.13941-13949
Hauptverfasser:	Lukin, Stipe, Stolar, Tomislav, Tireli, Martina, Blanco, Maria Valeria, Babić, Darko, Friščić, Tomislav, Užarević, Krunoslav, Halasz, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoic acid Cascade chemical reactions Chemistry Crystal structure Intermediates Kinetics mechanochemistry Monitoring Nicotinamide pharmaceutical cocrystals Phase transitions quantitative in situ monitoring Raman spectroscopy Reaction kinetics Slurries Spectroscopy synchrotron XRD
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!