A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway

In this study, we investigated the cardioprotective mechanisms of action of DT-010, a novel danshensu-tetramethylpyrazine conjugate. DT-010 significantly preserved cell viability and suppressed cell apoptosis in H9c2 cells injured by tert-butylhydroperoxide (t-BHP), iodoacetic acid (IAA) and hypoxia...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/09/01, Vol.40(9), pp.1490-1498
Hauptverfasser:	Zhang, Xiaojing, Hu, Huihui, Luo, Jingxiong, Deng, Huixing, Yu, Pei, Zhang, Zaijun, Zhang, Gaoxiao, Shan, Luchen, Wang, Yuqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cardiovascular diseases Cell Line Cell Survival Danshensu derivative Free radicals Free Radicals - metabolism Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Hydroxyl radicals Hypoxia Iodoacetic Acid Ischemia Lactates - pharmacology Lactates - therapeutic use Ligusticum Male Mitochondria Myocardial infarction Myocardial Infarction - etiology Myocardial Infarction - metabolism Myocardial Infarction - prevention & control Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - drug therapy Myocardial Ischemia - metabolism Myocardial Ischemia - pathology myocardial ischemia reperfusion injury Myocardium - cytology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NF-E2-Related Factor 2 - metabolism Nuclear transport Oxidation oxidative stress Oxygenase peroxisome proliferator-activated receptor gamma coactivator 1 alpha/nuclear factor-E2-related factor 2/heme oxygenase-1 (PGC-1α/Nrf2/HO-1) pathway Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxynitrite Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Pyrazines - pharmacology Pyrazines - therapeutic use Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Rodents Salvia miltiorrhiza Superoxide tert-Butylhydroperoxide Translocation Up-Regulation
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