Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology
Smooth septate junctions (sSJs) are cell–cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. R...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2017-06, Vol.1397 (1), p.17-24 |
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| creator | Furuse, Mikio Izumi, Yasushi |
| description | Smooth septate junctions (sSJs) are cell–cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ‐specific membrane proteins, Ssk and Mesh, were identified by screening monoclonal antibodies raised against sSJ‐containing membrane fractions isolated from the silkworm midgut. Furthermore, a genetic screen in Drosophila based on microscopic observation of sSJ formation identified Tsp2A as a novel sSJ‐specific membrane protein. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for sSJ formation, as well as intestinal barrier function in Drosophila. Additional studies are likely to elucidate their roles in (1) the formation and reorganization of sSJs, (2) paracellular barrier functions and permselectivity, and (3) short‐term and long‐term regulation of paracellular functions in arthropod epithelia. |
| doi_str_mv | 10.1111/nyas.13366 |
| format | Article |
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The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ‐specific membrane proteins, Ssk and Mesh, were identified by screening monoclonal antibodies raised against sSJ‐containing membrane fractions isolated from the silkworm midgut. Furthermore, a genetic screen in Drosophila based on microscopic observation of sSJ formation identified Tsp2A as a novel sSJ‐specific membrane protein. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for sSJ formation, as well as intestinal barrier function in Drosophila. 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The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ‐specific membrane proteins, Ssk and Mesh, were identified by screening monoclonal antibodies raised against sSJ‐containing membrane fractions isolated from the silkworm midgut. Furthermore, a genetic screen in Drosophila based on microscopic observation of sSJ formation identified Tsp2A as a novel sSJ‐specific membrane protein. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for sSJ formation, as well as intestinal barrier function in Drosophila. Additional studies are likely to elucidate their roles in (1) the formation and reorganization of sSJs, (2) paracellular barrier functions and permselectivity, and (3) short‐term and long‐term regulation of paracellular functions in arthropod epithelia.</description><subject>Animals</subject><subject>Arthropods</subject><subject>Arthropods - metabolism</subject><subject>Arthropods - physiology</subject><subject>Cell junctions</subject><subject>Dissection</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - metabolism</subject><subject>Fruit flies</subject><subject>Genetic screening</subject><subject>Insects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine</subject><subject>Kidneys</subject><subject>Malpighian tubules</subject><subject>Membrane proteins</subject><subject>Membrane Proteins - metabolism</subject><subject>Midgut</subject><subject>Models, Biological</subject><subject>Monoclonal antibodies</subject><subject>paracellular transport</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Screening</subject><subject>septate junctions</subject><subject>Signal Transduction - physiology</subject><subject>Tetraspanins - metabolism</subject><subject>Tight Junctions - metabolism</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKxDAYhuEgio6HjRcgATcidMyhTRN3Ip7Aw0JduCppmjoZOknN3yK9ezsz6sKF2WSRh5fwIXRIyZSO58wPGqaUcyE20ITmqUqE4GwTTQjJ80QqxnfQLsCcEMpkmm-jHSYFF5KQCTIPobGmb3TElQOwpnPB41BjWITQzTDYttOdxfPer57gHPe-shE67Svn33E3sy7iOFYAO4917GYxtKHC7WwAF5rwPuyjrVo3YA--7z30en31cnmb3D_d3F1e3CeGZ7lIBNGSZZUwXKWEZUzKWmhVZ1RpVQqaKptlJK9qaoxlZc15SYlNy4zzqjRlnfE9dLLutjF89Ba6YuHA2KbR3oYeCqooE0TmnI_0-A-dhz768XdLRSXhjKhRna6ViQEg2rpoo1voOBSUFMvpi-X0xWr6ER99J_tyYatf-rP1COgafLrGDv-kise3i-d19As08I_t</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Furuse, Mikio</creator><creator>Izumi, Yasushi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology</title><author>Furuse, Mikio ; Izumi, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-60a825d6c394025288f6a9f519a9b6149e5507df1cce2bf33b10e4b533dbcbf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Arthropods</topic><topic>Arthropods - metabolism</topic><topic>Arthropods - physiology</topic><topic>Cell junctions</topic><topic>Dissection</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - metabolism</topic><topic>Fruit flies</topic><topic>Genetic screening</topic><topic>Insects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine</topic><topic>Kidneys</topic><topic>Malpighian tubules</topic><topic>Membrane proteins</topic><topic>Membrane Proteins - metabolism</topic><topic>Midgut</topic><topic>Models, Biological</topic><topic>Monoclonal antibodies</topic><topic>paracellular transport</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Screening</topic><topic>septate junctions</topic><topic>Signal Transduction - physiology</topic><topic>Tetraspanins - metabolism</topic><topic>Tight Junctions - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuse, Mikio</creatorcontrib><creatorcontrib>Izumi, Yasushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuse, Mikio</au><au>Izumi, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2017-06</date><risdate>2017</risdate><volume>1397</volume><issue>1</issue><spage>17</spage><epage>24</epage><pages>17-24</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Smooth septate junctions (sSJs) are cell–cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ‐specific membrane proteins, Ssk and Mesh, were identified by screening monoclonal antibodies raised against sSJ‐containing membrane fractions isolated from the silkworm midgut. Furthermore, a genetic screen in Drosophila based on microscopic observation of sSJ formation identified Tsp2A as a novel sSJ‐specific membrane protein. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for sSJ formation, as well as intestinal barrier function in Drosophila. 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| subjects | Animals Arthropods Arthropods - metabolism Arthropods - physiology Cell junctions Dissection Drosophila Drosophila melanogaster - metabolism Drosophila melanogaster - physiology Drosophila Proteins - metabolism Fruit flies Genetic screening Insects Intestinal Mucosa - metabolism Intestine Kidneys Malpighian tubules Membrane proteins Membrane Proteins - metabolism Midgut Models, Biological Monoclonal antibodies paracellular transport Physiology Proteins Screening septate junctions Signal Transduction - physiology Tetraspanins - metabolism Tight Junctions - metabolism |
| title | Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology |
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