Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and...
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| Veröffentlicht in: | British journal of nutrition 2017-06, Vol.117 (11), p.1596-1602 |
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| creator | Zamora-Ros, Raul Rothwell, Joseph A. Achaintre, David Ferrari, Pietro Boutron-Ruault, Marie-Christine Mancini, Francesca R. Affret, Aurelie Kühn, Tilman Katzke, Verena Boeing, Heiner Küppel, Sven Trichopoulou, Antonia Lagiou, Pagona La Vecchia, Carlo Palli, Domenico Contiero, Paolo Panico, Salvatore Tumino, Rosario Ricceri, Fulvio Noh, Hwayoung Freisling, Heinz Romieu, Isabelle Scalbert, Augustin |
| description | In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included. Acute and habitual dietary data were collected using standardised 24-HDR software and a validated country-specific dietary questionnaire, respectively. Phenol-Explorer was used to estimate the intake of resveratrol and other stilbenes. Urinary resveratrol was analysed using tandem MS. Spearman’s correlation coefficients between estimated dietary intakes of resveratrol and other stilbenes and consumption of wine, their main food source, were very high (r>0·9) when measured using dietary questionnaires and were slightly lower with 24-HDR (r>0·8). Partial Spearman’s correlations between urinary resveratrol excretion and intake of resveratrol, total stilbenes or wine were found to be higher when using the 24-HDR (R
2
partial approximately 0·6) than when using the dietary questionnaires (R
2
partial approximately 0·5). Moderate to high correlations between dietary resveratrol, total stilbenes and wine, and urinary resveratrol concentrations were observed. These support the earlier findings that 24-h urinary resveratrol is an effective biomarker of both resveratrol and wine intakes. These correlations also support the validity of the estimation of resveratrol intake using the dietary questionnaire and Phenol-Explorer. |
| doi_str_mv | 10.1017/S0007114517001465 |
| format | Article |
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2
partial approximately 0·6) than when using the dietary questionnaires (R
2
partial approximately 0·5). Moderate to high correlations between dietary resveratrol, total stilbenes and wine, and urinary resveratrol concentrations were observed. These support the earlier findings that 24-h urinary resveratrol is an effective biomarker of both resveratrol and wine intakes. These correlations also support the validity of the estimation of resveratrol intake using the dietary questionnaire and Phenol-Explorer.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114517001465</identifier><identifier>PMID: 28637522</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Biomarkers ; Biomarkers - urine ; Cancer ; Chromatography ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Cross-Sectional Studies ; Diet ; Diet Surveys ; Dietary intake ; Dietary Surveys and Nutritional Epidemiology ; Epidemiology ; Europe ; Excretion ; Feeding Behavior ; Female ; Food ; Food sources ; Health care ; Humans ; In vitro methods and tests ; Male ; Medical research ; Men ; Mental Recall ; Metabolites ; Middle Aged ; Nutrition ; Phenols ; Phenols - urine ; Polyphenols ; Prospective Studies ; Public health ; Resveratrol ; Stilbenes - administration & dosage ; Stilbenes - urine ; Urine ; Wine ; Wines</subject><ispartof>British journal of nutrition, 2017-06, Vol.117 (11), p.1596-1602</ispartof><rights>Copyright © The Authors 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-6261f406d5bbd3ab886d1735e5164a73d61cc5d3de880dc92a96d18fc789bb013</citedby><cites>FETCH-LOGICAL-c416t-6261f406d5bbd3ab886d1735e5164a73d61cc5d3de880dc92a96d18fc789bb013</cites><orcidid>0000-0002-6978-8364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114517001465/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28637522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamora-Ros, Raul</creatorcontrib><creatorcontrib>Rothwell, Joseph A.</creatorcontrib><creatorcontrib>Achaintre, David</creatorcontrib><creatorcontrib>Ferrari, Pietro</creatorcontrib><creatorcontrib>Boutron-Ruault, Marie-Christine</creatorcontrib><creatorcontrib>Mancini, Francesca R.</creatorcontrib><creatorcontrib>Affret, Aurelie</creatorcontrib><creatorcontrib>Kühn, Tilman</creatorcontrib><creatorcontrib>Katzke, Verena</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Küppel, Sven</creatorcontrib><creatorcontrib>Trichopoulou, Antonia</creatorcontrib><creatorcontrib>Lagiou, Pagona</creatorcontrib><creatorcontrib>La Vecchia, Carlo</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Contiero, Paolo</creatorcontrib><creatorcontrib>Panico, Salvatore</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Ricceri, Fulvio</creatorcontrib><creatorcontrib>Noh, Hwayoung</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Romieu, Isabelle</creatorcontrib><creatorcontrib>Scalbert, Augustin</creatorcontrib><title>Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included. Acute and habitual dietary data were collected using standardised 24-HDR software and a validated country-specific dietary questionnaire, respectively. Phenol-Explorer was used to estimate the intake of resveratrol and other stilbenes. Urinary resveratrol was analysed using tandem MS. Spearman’s correlation coefficients between estimated dietary intakes of resveratrol and other stilbenes and consumption of wine, their main food source, were very high (r>0·9) when measured using dietary questionnaires and were slightly lower with 24-HDR (r>0·8). Partial Spearman’s correlations between urinary resveratrol excretion and intake of resveratrol, total stilbenes or wine were found to be higher when using the 24-HDR (R
2
partial approximately 0·6) than when using the dietary questionnaires (R
2
partial approximately 0·5). Moderate to high correlations between dietary resveratrol, total stilbenes and wine, and urinary resveratrol concentrations were observed. These support the earlier findings that 24-h urinary resveratrol is an effective biomarker of both resveratrol and wine intakes. These correlations also support the validity of the estimation of resveratrol intake using the dietary questionnaire and Phenol-Explorer.</description><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Cancer</subject><subject>Chromatography</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Diet Surveys</subject><subject>Dietary intake</subject><subject>Dietary Surveys and Nutritional Epidemiology</subject><subject>Epidemiology</subject><subject>Europe</subject><subject>Excretion</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>Food sources</subject><subject>Health care</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>Male</subject><subject>Medical research</subject><subject>Men</subject><subject>Mental Recall</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Phenols</subject><subject>Phenols - urine</subject><subject>Polyphenols</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Resveratrol</subject><subject>Stilbenes - administration & dosage</subject><subject>Stilbenes - urine</subject><subject>Urine</subject><subject>Wine</subject><subject>Wines</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kd1uEzEQhS1ERUPhAbhBlrgpFwue_fF6L1EUIFJFKwHXK689W9xu7OCfSHmavmq9JFRVEVej0fnOmdEMIW-AfQAG7cfvjLEWoG6gZQxq3jwjC6jbpig5L5-TxSwXs35KXoZwk1sBrHtBTkvBq7YpywW5W-3klGQ0zlI30uSNlX5PPYYdehm9m6gMVNLBuI30t-hnShuMTyljo7zFXGj8hXSVvNuitPTKu7BFFc0O6druMERzfZiWDY4upVU5U1pNv6XozR_lfHW1Xr6nISa9f0VORjkFfH2sZ-Tn59WP5dfi4vLLevnpolA18FjwksNYM66bYdCVHITgGtqqwQZ4LdtKc1Cq0ZVGIZhWXSm7DIhRtaIbBgbVGTk_5G69-53ymv3GBIXTJC26FHrooORMcOgy-u4JeuOSt3m7meo6xkUlMgUHSuULBI9jv_Umn3DfA-vn7_X_fC973h6T07BB_eD4-64MVMdQuRm80df4aPZ_Y-8BdfCl7A</recordid><startdate>20170614</startdate><enddate>20170614</enddate><creator>Zamora-Ros, Raul</creator><creator>Rothwell, Joseph A.</creator><creator>Achaintre, David</creator><creator>Ferrari, Pietro</creator><creator>Boutron-Ruault, Marie-Christine</creator><creator>Mancini, Francesca R.</creator><creator>Affret, Aurelie</creator><creator>Kühn, Tilman</creator><creator>Katzke, Verena</creator><creator>Boeing, Heiner</creator><creator>Küppel, Sven</creator><creator>Trichopoulou, Antonia</creator><creator>Lagiou, Pagona</creator><creator>La Vecchia, Carlo</creator><creator>Palli, Domenico</creator><creator>Contiero, Paolo</creator><creator>Panico, Salvatore</creator><creator>Tumino, Rosario</creator><creator>Ricceri, Fulvio</creator><creator>Noh, Hwayoung</creator><creator>Freisling, Heinz</creator><creator>Romieu, Isabelle</creator><creator>Scalbert, Augustin</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6978-8364</orcidid></search><sort><creationdate>20170614</creationdate><title>Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study</title><author>Zamora-Ros, Raul ; Rothwell, Joseph A. ; Achaintre, David ; Ferrari, Pietro ; Boutron-Ruault, Marie-Christine ; Mancini, Francesca R. ; Affret, Aurelie ; Kühn, Tilman ; Katzke, Verena ; Boeing, Heiner ; Küppel, Sven ; Trichopoulou, Antonia ; Lagiou, Pagona ; La Vecchia, Carlo ; Palli, Domenico ; Contiero, Paolo ; Panico, Salvatore ; Tumino, Rosario ; Ricceri, Fulvio ; Noh, Hwayoung ; Freisling, Heinz ; Romieu, Isabelle ; Scalbert, Augustin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-6261f406d5bbd3ab886d1735e5164a73d61cc5d3de880dc92a96d18fc789bb013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zamora-Ros, Raul</au><au>Rothwell, Joseph A.</au><au>Achaintre, David</au><au>Ferrari, Pietro</au><au>Boutron-Ruault, Marie-Christine</au><au>Mancini, Francesca R.</au><au>Affret, Aurelie</au><au>Kühn, Tilman</au><au>Katzke, Verena</au><au>Boeing, Heiner</au><au>Küppel, Sven</au><au>Trichopoulou, Antonia</au><au>Lagiou, Pagona</au><au>La Vecchia, Carlo</au><au>Palli, Domenico</au><au>Contiero, Paolo</au><au>Panico, Salvatore</au><au>Tumino, Rosario</au><au>Ricceri, Fulvio</au><au>Noh, Hwayoung</au><au>Freisling, Heinz</au><au>Romieu, Isabelle</au><au>Scalbert, Augustin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2017-06-14</date><risdate>2017</risdate><volume>117</volume><issue>11</issue><spage>1596</spage><epage>1602</epage><pages>1596-1602</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included. Acute and habitual dietary data were collected using standardised 24-HDR software and a validated country-specific dietary questionnaire, respectively. Phenol-Explorer was used to estimate the intake of resveratrol and other stilbenes. Urinary resveratrol was analysed using tandem MS. Spearman’s correlation coefficients between estimated dietary intakes of resveratrol and other stilbenes and consumption of wine, their main food source, were very high (r>0·9) when measured using dietary questionnaires and were slightly lower with 24-HDR (r>0·8). Partial Spearman’s correlations between urinary resveratrol excretion and intake of resveratrol, total stilbenes or wine were found to be higher when using the 24-HDR (R
2
partial approximately 0·6) than when using the dietary questionnaires (R
2
partial approximately 0·5). Moderate to high correlations between dietary resveratrol, total stilbenes and wine, and urinary resveratrol concentrations were observed. These support the earlier findings that 24-h urinary resveratrol is an effective biomarker of both resveratrol and wine intakes. These correlations also support the validity of the estimation of resveratrol intake using the dietary questionnaire and Phenol-Explorer.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>28637522</pmid><doi>10.1017/S0007114517001465</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6978-8364</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_proquest_miscellaneous_1912608619 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Free Full-Text Journals in Chemistry |
| subjects | Biomarkers Biomarkers - urine Cancer Chromatography Correlation analysis Correlation coefficient Correlation coefficients Cross-Sectional Studies Diet Diet Surveys Dietary intake Dietary Surveys and Nutritional Epidemiology Epidemiology Europe Excretion Feeding Behavior Female Food Food sources Health care Humans In vitro methods and tests Male Medical research Men Mental Recall Metabolites Middle Aged Nutrition Phenols Phenols - urine Polyphenols Prospective Studies Public health Resveratrol Stilbenes - administration & dosage Stilbenes - urine Urine Wine Wines |
| title | Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T18%3A08%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20urinary%20resveratrol%20as%20a%20biomarker%20of%20dietary%20resveratrol%20intake%20in%20the%20European%20Prospective%20Investigation%20into%20Cancer%20and%20Nutrition%20(EPIC)%20study&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Zamora-Ros,%20Raul&rft.date=2017-06-14&rft.volume=117&rft.issue=11&rft.spage=1596&rft.epage=1602&rft.pages=1596-1602&rft.issn=0007-1145&rft.eissn=1475-2662&rft_id=info:doi/10.1017/S0007114517001465&rft_dat=%3Cproquest_cross%3E1912608619%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1919906838&rft_id=info:pmid/28637522&rft_cupid=10_1017_S0007114517001465&rfr_iscdi=true |