Undetectable Mannose Binding Lectin and Corticosteroids Increase Serious Infection Risk in Rheumatoid Arthritis

Background Infection is the leading cause of death in rheumatoid arthritis (RA). Corticosteroid (CS) use is a known and important risk factor for serious infections (SIs). Mannose binding lectin (MBL) is a genetically determined component of the innate immune system implicated in neonatal infections...

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Veröffentlicht in:	The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2017-11, Vol.5 (6), p.1609-1616
Hauptverfasser:	Carroll, Graeme J., MD, Makin, Krista, MBBS, Garnsey, Maxine, MBBS, Bulsara, Max, PhD, Carroll, Bronwyn V., MBBS, Curtin, Shona M., MBBS, Allan, Erin M., BEng, McLean-Tooke, Andrew, MD, Bundell, Christine, PhD, Kemp, Monica L., MSc, Deshpande, Pooja, MSc, Ihdayhid, Dana, MBBS, Coleman, Sophie, PhD, Easter, Tracie, MSc, Triplett, James, MMed, Disteldorf, Timothy, MBBS, Marsden, C. Helen, MSc, Lucas, Michaela, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Adult Aged Aged, 80 and over Allergy and Immunology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - epidemiology Australia Corticosteroids Female Humans Immune system Immunity, Innate Infection - drug therapy Infection - epidemiology Infections Innate immunity Internal Medicine Laboratories Lectins Male Mannose Mannose binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - deficiency Metabolism, Inborn Errors - drug therapy Metabolism, Inborn Errors - epidemiology Middle Aged Neonates Neutropenia Prednisolone Rheumatoid arthritis Rheumatology Risk Risk factor Serious infection Statistical analysis Young Adult
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