Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety
Objectives To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi‐institutional dataset. Patients an...
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| Veröffentlicht in: | BJU international 2017-11, Vol.120 (5), p.682-688 |
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| creator | Rha, Koon H. Abdel Raheem, Ali Park, Sung Y. Kim, Kwang H. Kim, Hyung J. Koo, Kyo C. Choi, Young D. Jung, Byung H. Lee, Sang K. Lee, Won K. Krishnan, Jayram Shin, Tae Y. Cho, Jin‐Seon |
| description | Objectives
To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi‐institutional dataset.
Patients and Methods
We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot‐assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable.
Results
The mean (sd) RAIV was 24.2 (29.2) cm3. The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m2, respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow‐up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature.
Conclusion
Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long‐term follow‐up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques. |
| doi_str_mv | 10.1111/bju.13937 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1912195649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1951041983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3887-649cb6283e1eff633b3580ed64c850c6179df76e150a1111a51e14442257d4ad3</originalsourceid><addsrcrecordid>eNp1kctu1TAQhi0EohdY8ALIEhu6OK0dX5KIFVRciiqxoRK7yMcZtzly7GDHB51H5K2YNC0LJLzx2P78zz8zhLzi7JzjutjuyjkXraifkGMutdxIzn48fYxZq4_ISc47xvBCq-fkqGq0qFqhjsnvq3EydqbR0SlBnCCZedgDtcbb4jGOYXkLMN0lDPfRlxGojzlTPLoylwT3n02aB-NXEOwcxwOdwd6F4WeB_I5O3oQwhFtqaJ4xB9wOlqZo-tFM1MVEh3FKcb8QrgS75EU1tJQh7VcbJvQ0gy1pgWKw0UcUQSobB_PhBXnmjM_w8mE_JTefPn6__LK5_vb56vL99caKpqk3WrZ2q6tGAAfntBBboRoGvZa2UcxqXre9qzVwxczSXKM4cCllVam6l6YXp-Ttqot-l9rmbhyyBY8FQiy54y2veKswD6Jv_kF3sSQsbKEUZ5K3jUDqbKVswrYmcN2UhtGkQ8dZt1jocL7d_XyRff2gWLYj9H_Jx4EicLECvwYPh_8rdR--3qySfwDaZbSR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1951041983</pqid></control><display><type>article</type><title>Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Rha, Koon H. ; Abdel Raheem, Ali ; Park, Sung Y. ; Kim, Kwang H. ; Kim, Hyung J. ; Koo, Kyo C. ; Choi, Young D. ; Jung, Byung H. ; Lee, Sang K. ; Lee, Won K. ; Krishnan, Jayram ; Shin, Tae Y. ; Cho, Jin‐Seon</creator><creatorcontrib>Rha, Koon H. ; Abdel Raheem, Ali ; Park, Sung Y. ; Kim, Kwang H. ; Kim, Hyung J. ; Koo, Kyo C. ; Choi, Young D. ; Jung, Byung H. ; Lee, Sang K. ; Lee, Won K. ; Krishnan, Jayram ; Shin, Tae Y. ; Cho, Jin‐Seon</creatorcontrib><description>Objectives
To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi‐institutional dataset.
Patients and Methods
We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot‐assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable.
Results
The mean (sd) RAIV was 24.2 (29.2) cm3. The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m2, respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow‐up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature.
Conclusion
Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long‐term follow‐up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/bju.13937</identifier><identifier>PMID: 28632935</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Epidermal growth factor receptors ; Female ; Glomerular Filtration Rate ; Humans ; Kidney - physiopathology ; Kidney - surgery ; Kidney cancer ; kidney function ; Kidney Neoplasms - physiopathology ; Kidney Neoplasms - surgery ; Kidney transplantation ; Laparoscopy ; Male ; Middle Aged ; Nephrectomy ; Nephrectomy - methods ; Nephrectomy - statistics & numerical data ; Organ Sparing Treatments - methods ; Organ Sparing Treatments - statistics & numerical data ; Preoperative Care - methods ; Preservation ; Regression analysis ; renal cancer ; Renal function ; Retrospective Studies ; Robots</subject><ispartof>BJU international, 2017-11, Vol.120 (5), p.682-688</ispartof><rights>2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd</rights><rights>2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.</rights><rights>BJUI © 2017 BJU International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-649cb6283e1eff633b3580ed64c850c6179df76e150a1111a51e14442257d4ad3</citedby><cites>FETCH-LOGICAL-c3887-649cb6283e1eff633b3580ed64c850c6179df76e150a1111a51e14442257d4ad3</cites><orcidid>0000-0002-9294-2665 ; 0000-0002-8545-5797 ; 0000-0002-3910-9252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbju.13937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbju.13937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28632935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rha, Koon H.</creatorcontrib><creatorcontrib>Abdel Raheem, Ali</creatorcontrib><creatorcontrib>Park, Sung Y.</creatorcontrib><creatorcontrib>Kim, Kwang H.</creatorcontrib><creatorcontrib>Kim, Hyung J.</creatorcontrib><creatorcontrib>Koo, Kyo C.</creatorcontrib><creatorcontrib>Choi, Young D.</creatorcontrib><creatorcontrib>Jung, Byung H.</creatorcontrib><creatorcontrib>Lee, Sang K.</creatorcontrib><creatorcontrib>Lee, Won K.</creatorcontrib><creatorcontrib>Krishnan, Jayram</creatorcontrib><creatorcontrib>Shin, Tae Y.</creatorcontrib><creatorcontrib>Cho, Jin‐Seon</creatorcontrib><title>Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Objectives
To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi‐institutional dataset.
Patients and Methods
We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot‐assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable.
Results
The mean (sd) RAIV was 24.2 (29.2) cm3. The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m2, respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow‐up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature.
Conclusion
Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long‐term follow‐up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques.</description><subject>Adult</subject><subject>Aged</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney - surgery</subject><subject>Kidney cancer</subject><subject>kidney function</subject><subject>Kidney Neoplasms - physiopathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidney transplantation</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrectomy</subject><subject>Nephrectomy - methods</subject><subject>Nephrectomy - statistics & numerical data</subject><subject>Organ Sparing Treatments - methods</subject><subject>Organ Sparing Treatments - statistics & numerical data</subject><subject>Preoperative Care - methods</subject><subject>Preservation</subject><subject>Regression analysis</subject><subject>renal cancer</subject><subject>Renal function</subject><subject>Retrospective Studies</subject><subject>Robots</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhi0EohdY8ALIEhu6OK0dX5KIFVRciiqxoRK7yMcZtzly7GDHB51H5K2YNC0LJLzx2P78zz8zhLzi7JzjutjuyjkXraifkGMutdxIzn48fYxZq4_ISc47xvBCq-fkqGq0qFqhjsnvq3EydqbR0SlBnCCZedgDtcbb4jGOYXkLMN0lDPfRlxGojzlTPLoylwT3n02aB-NXEOwcxwOdwd6F4WeB_I5O3oQwhFtqaJ4xB9wOlqZo-tFM1MVEh3FKcb8QrgS75EU1tJQh7VcbJvQ0gy1pgWKw0UcUQSobB_PhBXnmjM_w8mE_JTefPn6__LK5_vb56vL99caKpqk3WrZ2q6tGAAfntBBboRoGvZa2UcxqXre9qzVwxczSXKM4cCllVam6l6YXp-Ttqot-l9rmbhyyBY8FQiy54y2veKswD6Jv_kF3sSQsbKEUZ5K3jUDqbKVswrYmcN2UhtGkQ8dZt1jocL7d_XyRff2gWLYj9H_Jx4EicLECvwYPh_8rdR--3qySfwDaZbSR</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Rha, Koon H.</creator><creator>Abdel Raheem, Ali</creator><creator>Park, Sung Y.</creator><creator>Kim, Kwang H.</creator><creator>Kim, Hyung J.</creator><creator>Koo, Kyo C.</creator><creator>Choi, Young D.</creator><creator>Jung, Byung H.</creator><creator>Lee, Sang K.</creator><creator>Lee, Won K.</creator><creator>Krishnan, Jayram</creator><creator>Shin, Tae Y.</creator><creator>Cho, Jin‐Seon</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9294-2665</orcidid><orcidid>https://orcid.org/0000-0002-8545-5797</orcidid><orcidid>https://orcid.org/0000-0002-3910-9252</orcidid></search><sort><creationdate>201711</creationdate><title>Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety</title><author>Rha, Koon H. ; Abdel Raheem, Ali ; Park, Sung Y. ; Kim, Kwang H. ; Kim, Hyung J. ; Koo, Kyo C. ; Choi, Young D. ; Jung, Byung H. ; Lee, Sang K. ; Lee, Won K. ; Krishnan, Jayram ; Shin, Tae Y. ; Cho, Jin‐Seon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-649cb6283e1eff633b3580ed64c850c6179df76e150a1111a51e14442257d4ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney - surgery</topic><topic>Kidney cancer</topic><topic>kidney function</topic><topic>Kidney Neoplasms - physiopathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidney transplantation</topic><topic>Laparoscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrectomy</topic><topic>Nephrectomy - methods</topic><topic>Nephrectomy - statistics & numerical data</topic><topic>Organ Sparing Treatments - methods</topic><topic>Organ Sparing Treatments - statistics & numerical data</topic><topic>Preoperative Care - methods</topic><topic>Preservation</topic><topic>Regression analysis</topic><topic>renal cancer</topic><topic>Renal function</topic><topic>Retrospective Studies</topic><topic>Robots</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rha, Koon H.</creatorcontrib><creatorcontrib>Abdel Raheem, Ali</creatorcontrib><creatorcontrib>Park, Sung Y.</creatorcontrib><creatorcontrib>Kim, Kwang H.</creatorcontrib><creatorcontrib>Kim, Hyung J.</creatorcontrib><creatorcontrib>Koo, Kyo C.</creatorcontrib><creatorcontrib>Choi, Young D.</creatorcontrib><creatorcontrib>Jung, Byung H.</creatorcontrib><creatorcontrib>Lee, Sang K.</creatorcontrib><creatorcontrib>Lee, Won K.</creatorcontrib><creatorcontrib>Krishnan, Jayram</creatorcontrib><creatorcontrib>Shin, Tae Y.</creatorcontrib><creatorcontrib>Cho, Jin‐Seon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rha, Koon H.</au><au>Abdel Raheem, Ali</au><au>Park, Sung Y.</au><au>Kim, Kwang H.</au><au>Kim, Hyung J.</au><au>Koo, Kyo C.</au><au>Choi, Young D.</au><au>Jung, Byung H.</au><au>Lee, Sang K.</au><au>Lee, Won K.</au><au>Krishnan, Jayram</au><au>Shin, Tae Y.</au><au>Cho, Jin‐Seon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2017-11</date><risdate>2017</risdate><volume>120</volume><issue>5</issue><spage>682</spage><epage>688</epage><pages>682-688</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>Objectives
To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi‐institutional dataset.
Patients and Methods
We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot‐assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable.
Results
The mean (sd) RAIV was 24.2 (29.2) cm3. The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m2, respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow‐up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature.
Conclusion
Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long‐term follow‐up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28632935</pmid><doi>10.1111/bju.13937</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9294-2665</orcidid><orcidid>https://orcid.org/0000-0002-8545-5797</orcidid><orcidid>https://orcid.org/0000-0002-3910-9252</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Epidermal growth factor receptors Female Glomerular Filtration Rate Humans Kidney - physiopathology Kidney - surgery Kidney cancer kidney function Kidney Neoplasms - physiopathology Kidney Neoplasms - surgery Kidney transplantation Laparoscopy Male Middle Aged Nephrectomy Nephrectomy - methods Nephrectomy - statistics & numerical data Organ Sparing Treatments - methods Organ Sparing Treatments - statistics & numerical data Preoperative Care - methods Preservation Regression analysis renal cancer Renal function Retrospective Studies Robots |
| title | Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety |
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