Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β

Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss i...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2017-08, Vol.49 (8), p.722-728
Hauptverfasser:	Lu, Fen, Li, Xu, Li, Wei, Wei, Ke, Yao, Yong, Zhang, Qianlin, Liang, Xinliang, Zhang, Jiewen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - chemically induced Alzheimer Disease - metabolism Alzheimer Disease - prevention & control Animals Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Hippocampus - drug effects Hippocampus - metabolism Injections, Intraventricular Learning - drug effects Male Memory - drug effects Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - prevention & control Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Pyrazines - pharmacology Rats, Wistar Streptozocin 侧脑室注射学习记忆能力川芎嗪心血管疾病神经保护作用认知功能障碍诱导链脲佐菌素
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