Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β
Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss i...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2017-08, Vol.49 (8), p.722-728 |
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| container_title | Acta biochimica et biophysica Sinica |
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| creator | Lu, Fen Li, Xu Li, Wei Wei, Ke Yao, Yong Zhang, Qianlin Liang, Xinliang Zhang, Jiewen |
| description | Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine （TMP） is one of the major bioactive com- pounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegen- erative diseases, including Parkinson＇s disease. However, whether TMP plays a neuroprotective role in AD is still unknown. Here, we report that 2-week treatment with TMP rescued both short- term and long-term fear memory impairment induced by intracerebroventricular injection of strep- tozotocin in a well-known AD rat model. Administration of TMP also restored spatial learning and memory retention abilities in streptozotocin-injected rats. Furthermore, TMP inhibited the activity of GSK-3β, an important kinase that mediates hippocampal synaptic and memory disorders in dia- betes mellitus. Finally, we found that TMP treatment restored the function of cholinergic neurons. Our data suggest that dietary uptake of TMP can provide protection against memory loss in AD, and the inhibition of GSK-3β may play an important role in this protective effect. |
| doi_str_mv | 10.1093/abbs/gmx059 |
| format | Article |
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At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine （TMP） is one of the major bioactive com- pounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegen- erative diseases, including Parkinson＇s disease. However, whether TMP plays a neuroprotective role in AD is still unknown. Here, we report that 2-week treatment with TMP rescued both short- term and long-term fear memory impairment induced by intracerebroventricular injection of strep- tozotocin in a well-known AD rat model. Administration of TMP also restored spatial learning and memory retention abilities in streptozotocin-injected rats. Furthermore, TMP inhibited the activity of GSK-3β, an important kinase that mediates hippocampal synaptic and memory disorders in dia- betes mellitus. Finally, we found that TMP treatment restored the function of cholinergic neurons. Our data suggest that dietary uptake of TMP can provide protection against memory loss in AD, and the inhibition of GSK-3β may play an important role in this protective effect.</description><identifier>ISSN: 1672-9145</identifier><identifier>EISSN: 1745-7270</identifier><identifier>DOI: 10.1093/abbs/gmx059</identifier><identifier>PMID: 28633346</identifier><language>eng</language><publisher>China</publisher><subject>Alzheimer Disease - chemically induced ; Alzheimer Disease - metabolism ; Alzheimer Disease - prevention & control ; Animals ; Glycogen Synthase Kinase 3 - antagonists & inhibitors ; Glycogen Synthase Kinase 3 - metabolism ; Hippocampus - drug effects ; Hippocampus - metabolism ; Injections, Intraventricular ; Learning - drug effects ; Male ; Memory - drug effects ; Memory Disorders - chemically induced ; Memory Disorders - metabolism ; Memory Disorders - prevention & control ; Neurons - drug effects ; Neurons - metabolism ; Neuroprotective Agents - pharmacology ; Pyrazines - pharmacology ; Rats, Wistar ; Streptozocin ; 侧脑室注射 ; 学习记忆能力 ; 川芎嗪 ; 心血管疾病 ; 神经保护作用 ; 认知功能障碍 ; 诱导 ; 链脲佐菌素</subject><ispartof>Acta biochimica et biophysica Sinica, 2017-08, Vol.49 (8), p.722-728</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-f77a7dbd12f0f6e814a16d791c9047e9fe668567fc4160c591f21bc76fdb41223</citedby><cites>FETCH-LOGICAL-c316t-f77a7dbd12f0f6e814a16d791c9047e9fe668567fc4160c591f21bc76fdb41223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90160X/90160X.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28633346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Fen</creatorcontrib><creatorcontrib>Li, Xu</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Wei, Ke</creatorcontrib><creatorcontrib>Yao, Yong</creatorcontrib><creatorcontrib>Zhang, Qianlin</creatorcontrib><creatorcontrib>Liang, Xinliang</creatorcontrib><creatorcontrib>Zhang, Jiewen</creatorcontrib><title>Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β</title><title>Acta biochimica et biophysica Sinica</title><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><description>Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine （TMP） is one of the major bioactive com- pounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegen- erative diseases, including Parkinson＇s disease. However, whether TMP plays a neuroprotective role in AD is still unknown. Here, we report that 2-week treatment with TMP rescued both short- term and long-term fear memory impairment induced by intracerebroventricular injection of strep- tozotocin in a well-known AD rat model. Administration of TMP also restored spatial learning and memory retention abilities in streptozotocin-injected rats. Furthermore, TMP inhibited the activity of GSK-3β, an important kinase that mediates hippocampal synaptic and memory disorders in dia- betes mellitus. Finally, we found that TMP treatment restored the function of cholinergic neurons. Our data suggest that dietary uptake of TMP can provide protection against memory loss in AD, and the inhibition of GSK-3β may play an important role in this protective effect.</description><subject>Alzheimer Disease - chemically induced</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - prevention & control</subject><subject>Animals</subject><subject>Glycogen Synthase Kinase 3 - antagonists & inhibitors</subject><subject>Glycogen Synthase Kinase 3 - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Injections, Intraventricular</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - metabolism</subject><subject>Memory Disorders - prevention & control</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Pyrazines - pharmacology</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><subject>侧脑室注射</subject><subject>学习记忆能力</subject><subject>川芎嗪</subject><subject>心血管疾病</subject><subject>神经保护作用</subject><subject>认知功能障碍</subject><subject>诱导</subject><subject>链脲佐菌素</subject><issn>1672-9145</issn><issn>1745-7270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFq3DAQQEVpaNK0p96L6SkQ3GgkW1odS2jSkkAOTc9Gkke7Kra1K8mhzmflQ_pNUdhtThoxjwfzCPkE9CtQxS-0MeliPf6lrXpDTkA2bS2ZpG_LLCSrFTTtMXmf0h9KuRBA35FjthKc80ackN095qhHzJtl2C5RP_oJq4gPGBOmyk9laTGiieEBy8fbedCxSjniNofHkIP1U-2nfrbYVyOOIS5Vj85bn1NllmLYeOOzn9bV9a-bmv97-kCOnB4Sfjy8p-T31ff7yx_17d31z8tvt7XlIHLtpNSyNz0wR53AFTQaRC8VWEUbicqhEKtWSGcbENS2ChwDY6VwvWmAMX5KzvbebQy7GVPuRp8sDoOeMMypAwUMVCugKej5HrUxpBTRddvoRx2XDmj30rh7adztGxf680E8mxH7V_Z_1AJ8Oeg2YVrvyu2vjJBcMqoK-QxhpYhK</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Lu, Fen</creator><creator>Li, Xu</creator><creator>Li, Wei</creator><creator>Wei, Ke</creator><creator>Yao, Yong</creator><creator>Zhang, Qianlin</creator><creator>Liang, Xinliang</creator><creator>Zhang, Jiewen</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β</title><author>Lu, Fen ; Li, Xu ; Li, Wei ; Wei, Ke ; Yao, Yong ; Zhang, Qianlin ; Liang, Xinliang ; Zhang, Jiewen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-f77a7dbd12f0f6e814a16d791c9047e9fe668567fc4160c591f21bc76fdb41223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alzheimer Disease - chemically induced</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - prevention & control</topic><topic>Animals</topic><topic>Glycogen Synthase Kinase 3 - antagonists & inhibitors</topic><topic>Glycogen Synthase Kinase 3 - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Injections, Intraventricular</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Memory Disorders - chemically induced</topic><topic>Memory Disorders - metabolism</topic><topic>Memory Disorders - prevention & control</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Pyrazines - pharmacology</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><topic>侧脑室注射</topic><topic>学习记忆能力</topic><topic>川芎嗪</topic><topic>心血管疾病</topic><topic>神经保护作用</topic><topic>认知功能障碍</topic><topic>诱导</topic><topic>链脲佐菌素</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Fen</creatorcontrib><creatorcontrib>Li, Xu</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Wei, Ke</creatorcontrib><creatorcontrib>Yao, Yong</creatorcontrib><creatorcontrib>Zhang, Qianlin</creatorcontrib><creatorcontrib>Liang, Xinliang</creatorcontrib><creatorcontrib>Zhang, Jiewen</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biochimica et biophysica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Fen</au><au>Li, Xu</au><au>Li, Wei</au><au>Wei, Ke</au><au>Yao, Yong</au><au>Zhang, Qianlin</au><au>Liang, Xinliang</au><au>Zhang, Jiewen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β</atitle><jtitle>Acta biochimica et biophysica Sinica</jtitle><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>49</volume><issue>8</issue><spage>722</spage><epage>728</epage><pages>722-728</pages><issn>1672-9145</issn><eissn>1745-7270</eissn><abstract>Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer＇s disease （AD）, which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine （TMP） is one of the major bioactive com- pounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegen- erative diseases, including Parkinson＇s disease. However, whether TMP plays a neuroprotective role in AD is still unknown. Here, we report that 2-week treatment with TMP rescued both short- term and long-term fear memory impairment induced by intracerebroventricular injection of strep- tozotocin in a well-known AD rat model. Administration of TMP also restored spatial learning and memory retention abilities in streptozotocin-injected rats. Furthermore, TMP inhibited the activity of GSK-3β, an important kinase that mediates hippocampal synaptic and memory disorders in dia- betes mellitus. Finally, we found that TMP treatment restored the function of cholinergic neurons. Our data suggest that dietary uptake of TMP can provide protection against memory loss in AD, and the inhibition of GSK-3β may play an important role in this protective effect.</abstract><cop>China</cop><pmid>28633346</pmid><doi>10.1093/abbs/gmx059</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-9145 |
| ispartof | Acta biochimica et biophysica Sinica, 2017-08, Vol.49 (8), p.722-728 |
| issn | 1672-9145 1745-7270 |
| language | eng |
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| source | PubMed Central database; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Alzheimer Disease - chemically induced Alzheimer Disease - metabolism Alzheimer Disease - prevention & control Animals Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Hippocampus - drug effects Hippocampus - metabolism Injections, Intraventricular Learning - drug effects Male Memory - drug effects Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - prevention & control Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Pyrazines - pharmacology Rats, Wistar Streptozocin 侧脑室注射 学习记忆能力 川芎嗪 心血管疾病 神经保护作用 认知功能障碍 诱导 链脲佐菌素 |
| title | Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β |
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