Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression
There are various theories to explain the pathophysiology of depression and support its diagnosis and treatment. The roles of monoamines, brain‐derived neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic hedgehog (Shh) signaling and its downstream transcription factor Gli1 a...
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| Veröffentlicht in: | Journal of neuroscience research 2018-01, Vol.96 (1), p.53-62 |
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| creator | Tayyab, Mohd Shahi, Mehdi H. Farheen, Shirin Mariyath, Mubeena P.M. Khanam, Nabeela Castresana, Javier S. Hossain, M. Mobarak |
| description | There are various theories to explain the pathophysiology of depression and support its diagnosis and treatment. The roles of monoamines, brain‐derived neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic hedgehog (Shh) signaling and its downstream transcription factor Gli1 are not well studied in depression. Shh signaling plays a fundamental role in embryonic development and adult hippocampal neurogenesis and also involved in the growth of cancer. In this article, we summarize the evidence for the Shh signaling pathway in depression and the potential crosstalk of Shh with Wnt and BDNF. Antidepressants are known to upregulate the adult hippocampal neurogenesis to treat depression. Shh plays an important role in adult hippocampal neurogenesis, and its downstream signaling components regulate the synthesis of Wnt proteins.
Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and Wnt signaling are also regulated by various available antidepressants, so there is the possibility that Shh may be involved in the pathophysiology of depression. Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is being discussed to identify the potential targets. Specifically, the potential role of the Shh signaling pathway in depression is explored as a new target for better therapies for depression. |
| doi_str_mv | 10.1002/jnr.24104 |
| format | Article |
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Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and Wnt signaling are also regulated by various available antidepressants, so there is the possibility that Shh may be involved in the pathophysiology of depression. Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is being discussed to identify the potential targets. Specifically, the potential role of the Shh signaling pathway in depression is explored as a new target for better therapies for depression.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.24104</identifier><identifier>PMID: 28631844</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antidepressants ; Antidepressive Agents - administration & dosage ; Antidepressive Agents - metabolism ; BDNF ; Brain ; Brain-derived neurotrophic factor ; Cancer ; Crosstalk ; depression ; Depression - drug therapy ; Depression - metabolism ; Drug Delivery Systems - trends ; Embryogenesis ; Embryonic growth stage ; Hedgehog protein ; Hedgehog Proteins - metabolism ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Humans ; Mental depression ; Monoamines ; Neurogenesis ; Neurogenesis - drug effects ; Neurogenesis - physiology ; Proteins ; Receptor Cross-Talk - drug effects ; Receptor Cross-Talk - physiology ; Signal transduction ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Signaling ; sonic hedgehog ; Target recognition ; Wnt ; Wnt protein ; Wnt Signaling Pathway - drug effects ; Wnt Signaling Pathway - physiology</subject><ispartof>Journal of neuroscience research, 2018-01, Vol.96 (1), p.53-62</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-d58396429a110f322dc54b915f50a3f9077e1eb016f607969d23586d081aaca23</citedby><cites>FETCH-LOGICAL-c3534-d58396429a110f322dc54b915f50a3f9077e1eb016f607969d23586d081aaca23</cites><orcidid>0000-0001-9589-4382</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.24104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.24104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28631844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tayyab, Mohd</creatorcontrib><creatorcontrib>Shahi, Mehdi H.</creatorcontrib><creatorcontrib>Farheen, Shirin</creatorcontrib><creatorcontrib>Mariyath, Mubeena P.M.</creatorcontrib><creatorcontrib>Khanam, Nabeela</creatorcontrib><creatorcontrib>Castresana, Javier S.</creatorcontrib><creatorcontrib>Hossain, M. Mobarak</creatorcontrib><title>Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression</title><title>Journal of neuroscience research</title><addtitle>J Neurosci Res</addtitle><description>There are various theories to explain the pathophysiology of depression and support its diagnosis and treatment. The roles of monoamines, brain‐derived neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic hedgehog (Shh) signaling and its downstream transcription factor Gli1 are not well studied in depression. Shh signaling plays a fundamental role in embryonic development and adult hippocampal neurogenesis and also involved in the growth of cancer. In this article, we summarize the evidence for the Shh signaling pathway in depression and the potential crosstalk of Shh with Wnt and BDNF. Antidepressants are known to upregulate the adult hippocampal neurogenesis to treat depression. Shh plays an important role in adult hippocampal neurogenesis, and its downstream signaling components regulate the synthesis of Wnt proteins.
Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and Wnt signaling are also regulated by various available antidepressants, so there is the possibility that Shh may be involved in the pathophysiology of depression. Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is being discussed to identify the potential targets. Specifically, the potential role of the Shh signaling pathway in depression is explored as a new target for better therapies for depression.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - administration & dosage</subject><subject>Antidepressive Agents - metabolism</subject><subject>BDNF</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cancer</subject><subject>Crosstalk</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Depression - metabolism</subject><subject>Drug Delivery Systems - trends</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Hedgehog protein</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Mental depression</subject><subject>Monoamines</subject><subject>Neurogenesis</subject><subject>Neurogenesis - drug effects</subject><subject>Neurogenesis - physiology</subject><subject>Proteins</subject><subject>Receptor Cross-Talk - drug effects</subject><subject>Receptor Cross-Talk - physiology</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>Signaling</subject><subject>sonic hedgehog</subject><subject>Target recognition</subject><subject>Wnt</subject><subject>Wnt protein</subject><subject>Wnt Signaling Pathway - drug effects</subject><subject>Wnt Signaling Pathway - physiology</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1u1DAQB3ALgehSOPACyBKXIjXtjO3YcW-o4qOoAokPcYy8sbPxkrWDnbTaEzwCz8iTNNstHJA4zeU3f83oT8hThBMEYKfrkE6YQBD3yAJBq0KUQt0nC-ASCgHIDsijnNcAoHXJH5IDVkmOlRAL8uNTDL6hnbMr18XVMf0axmNqgqXLZHz4_fOXdclfOUuDm1IcUxy62bemGWOijet7mv0qmN6HFR3M2F2bLW1SzHk0_bczOsTRhdGbno6dS2bY0nbes25ILmcfw2PyoDV9dk_u5iH58vrV5_O3xeWHNxfnLy-LhpdcFLasuJaCaYMILWfMNqVYaizbEgxvNSjl0C0BZStBaakt42UlLVRoTGMYPyRH-9whxe-Ty2O98Xl3vgkuTrlGjaiQCaVm-vwfuo5Tml_cKYlKKqbErF7s1e2zybX1kPzGpG2NUO9aqedW6ttWZvvsLnFabpz9K__UMIPTPbj2vdv-P6l-9_7jPvIGtvOX1A</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Tayyab, Mohd</creator><creator>Shahi, Mehdi H.</creator><creator>Farheen, Shirin</creator><creator>Mariyath, Mubeena P.M.</creator><creator>Khanam, Nabeela</creator><creator>Castresana, Javier S.</creator><creator>Hossain, M. 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Mobarak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J Neurosci Res</addtitle><date>2018-01</date><risdate>2018</risdate><volume>96</volume><issue>1</issue><spage>53</spage><epage>62</epage><pages>53-62</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>There are various theories to explain the pathophysiology of depression and support its diagnosis and treatment. The roles of monoamines, brain‐derived neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic hedgehog (Shh) signaling and its downstream transcription factor Gli1 are not well studied in depression. Shh signaling plays a fundamental role in embryonic development and adult hippocampal neurogenesis and also involved in the growth of cancer. In this article, we summarize the evidence for the Shh signaling pathway in depression and the potential crosstalk of Shh with Wnt and BDNF. Antidepressants are known to upregulate the adult hippocampal neurogenesis to treat depression. Shh plays an important role in adult hippocampal neurogenesis, and its downstream signaling components regulate the synthesis of Wnt proteins.
Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and Wnt signaling are also regulated by various available antidepressants, so there is the possibility that Shh may be involved in the pathophysiology of depression. Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is being discussed to identify the potential targets. Specifically, the potential role of the Shh signaling pathway in depression is explored as a new target for better therapies for depression.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28631844</pmid><doi>10.1002/jnr.24104</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9589-4382</orcidid></addata></record> |
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| subjects | Animals Antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - metabolism BDNF Brain Brain-derived neurotrophic factor Cancer Crosstalk depression Depression - drug therapy Depression - metabolism Drug Delivery Systems - trends Embryogenesis Embryonic growth stage Hedgehog protein Hedgehog Proteins - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans Mental depression Monoamines Neurogenesis Neurogenesis - drug effects Neurogenesis - physiology Proteins Receptor Cross-Talk - drug effects Receptor Cross-Talk - physiology Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signaling sonic hedgehog Target recognition Wnt Wnt protein Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - physiology |
| title | Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression |
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