The IL–10/STAT3 axis: Contributions to immune tolerance by thymus and peripherally derived regulatory T‐cells

The signal transducer and activator of transcription (STAT) proteins are important mediators for the integration of extrinsic signals provided by cytokines and hormones and thereby adapt cellular processes to their surroundings. In the past decade, the involvement of STAT3 in the regulation of T‐cel...

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Veröffentlicht in:	European journal of immunology 2017-08, Vol.47 (8), p.1256-1265
Hauptverfasser:	Schmetterer, Klaus G., Pickl, Winfried F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Autoimmune diseases Autoimmune Diseases - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Differentiation Cytokines Cytokines - immunology Gene Expression Regulation Humans IL–10 Immune Tolerance Immunoglobulin E Immunological tolerance Inflammatory bowel diseases Inflammatory Bowel Diseases - immunology Integration Interleukin 10 Interleukin 6 Interleukin-10 - metabolism Interleukin-6 - immunology Interleukin-6 - metabolism Intestine Job Syndrome - immunology Lymphocytes T Mice Proteins Regulatory T‐cells Signal Transduction STAT3 Stat3 protein STAT3 Transcription Factor - metabolism T cell receptors T-Lymphocytes, Regulatory - immunology Thymus Thymus Gland - cytology Thymus Gland - immunology Tolerance Tr1 cells Transcription
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