Chemically induced mouse models of acute and chronic intestinal inflammation

This protocol update describes how to generate mouse models of inflammatory bowel diseases and methods for analyzing disease progression. Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further potential complications such as tissue fibrosis and stenosis. Animal models...

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Veröffentlicht in:	Nature protocols 2017-07, Vol.12 (7), p.1295-1309
Hauptverfasser:	Wirtz, Stefan, Popp, Vanessa, Kindermann, Markus, Gerlach, Katharina, Weigmann, Benno, Fichtner-Feigl, Stefan, Neurath, Markus F
Format:	Artikel
Sprache:	eng
Schlagworte:	59/5 631/1647/334/1874/345 631/1647/767/2199 692/4020/1503 692/4020/2741/278/1390 Adaptive immunity Analytical Chemistry Animal experimentation Animal models Animal research Animals Antigens Benzene Biological Techniques Cell-mediated immunity Chronic Disease Colitis Colitis - chemically induced Colitis - pathology Colon Computational Biology/Bioinformatics Dextran Dextran sulfate Dextran Sulfate - administration & dosage Dextran Sulfate - toxicity Diarrhea Disease Models, Animal Epithelial cells Fibrosis Flares Immunity Immunopathogenesis Inflammatory bowel disease Inflammatory bowel diseases Intestinal diseases Intestine Laboratory animals Life Sciences Lymphocytes T Methods Mice Microarrays Organic Chemistry Oxazolone Oxazolone - administration & dosage Oxazolone - toxicity Pain Proteins protocol-update Reagents Rodents Sodium Stenosis Sulfates Sulfonic acid Trinitrobenzenesulfonic Acid - administration & dosage Trinitrobenzenesulfonic Acid - toxicity
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