Total synthesis of marine natural products separacenes A and B
A short and convergent route for the stereoselective total synthesis of separacenes A and B has been developed using (+)-methyl d-lactate and d-(-)-tartaric acid as the chiral pools. The characteristic features of this synthesis include the Trost-Rychnovsky alkyne rearrangement to construct the C -C...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2017, Vol.15 (22), p.4842-4850 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Das, Subhendu Goswami, Rajib Kumar |
| description | A short and convergent route for the stereoselective total synthesis of separacenes A and B has been developed using (+)-methyl d-lactate and d-(-)-tartaric acid as the chiral pools. The characteristic features of this synthesis include the Trost-Rychnovsky alkyne rearrangement to construct the C
-C
conjugated diene, the Horner-Wadsworth-Emmons olefination to form the C
-C
and C
-C
olefins and the Corey-Bakshi-Shibata reaction to install the C-13 hydroxy functionality. |
| doi_str_mv | 10.1039/c7ob00345e |
| format | Article |
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-C
conjugated diene, the Horner-Wadsworth-Emmons olefination to form the C
-C
and C
-C
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-C
conjugated diene, the Horner-Wadsworth-Emmons olefination to form the C
-C
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-C
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-C
conjugated diene, the Horner-Wadsworth-Emmons olefination to form the C
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2017, Vol.15 (22), p.4842-4850 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1911619047 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Products - chemical synthesis Biological Products - chemistry Molecular Structure Polyenes - chemical synthesis Polyenes - chemistry Stereoisomerism |
| title | Total synthesis of marine natural products separacenes A and B |
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