Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma
[Display omitted] Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bila...
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| Veröffentlicht in: | Acta biomaterialia 2017-08, Vol.58, p.399-412 |
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| creator | Zhu, Dunwan Wu, Shengjie Hu, Chunyan Chen, Zhuo Wang, Hai Fan, Fan Qin, Yu Wang, Chun Sun, Hongfan Leng, Xigang Kong, Deling Zhang, Linhua |
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Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bilayered lamellar structure were successfully developed to co-encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (PTX and DOX) in a single vesicle for enhancing the combination chemotherapeutic effect. Hydrophobic PTX was loaded into the thick hydrophobic lamellar membrane by the self-assembly of triblock copolymer PCL8000-PEG8000-PCL8000, while hydrophilic DOX was encapsulated into the hydrophilic reservoir using a trans-membrane ammonium sulfate gradient method. In vitro release study indicated that the drugs were released from the polymersomes in a controlled and sustained manner. Cellular uptake study indicated that FA-targeted Co-PS had higher internalization efficiency in FA receptor-overexpressing BEL-7404 cells than non-targeted Co-PS. In vitro cytotoxicity assay demonstrated that FA-targeted Co-PS exhibited less cytotoxic effect than free drug cocktail, but suppressed the growth of tumor cells more efficiently than non-targeted Co-PS. Ex vivo imaging biodistribution studies revealed that FA-targeted Co-PS led to highly efficient targeting and accumulation in the BEL-7404 xenograft tumor. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of polymersomes to BEL-7404 tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In our study, novel folate-targeted co-delivery polymersomes (Co-PS) were successfully developed to encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (paclitaxel and doxorubicin) into the different compartments of the vesicle. In vivo studies revealed that the combination chemotherapy of polymersomes to BEL-7404 xenograft tumor v |
| doi_str_mv | 10.1016/j.actbio.2017.06.017 |
| format | Article |
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Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bilayered lamellar structure were successfully developed to co-encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (PTX and DOX) in a single vesicle for enhancing the combination chemotherapeutic effect. Hydrophobic PTX was loaded into the thick hydrophobic lamellar membrane by the self-assembly of triblock copolymer PCL8000-PEG8000-PCL8000, while hydrophilic DOX was encapsulated into the hydrophilic reservoir using a trans-membrane ammonium sulfate gradient method. In vitro release study indicated that the drugs were released from the polymersomes in a controlled and sustained manner. Cellular uptake study indicated that FA-targeted Co-PS had higher internalization efficiency in FA receptor-overexpressing BEL-7404 cells than non-targeted Co-PS. In vitro cytotoxicity assay demonstrated that FA-targeted Co-PS exhibited less cytotoxic effect than free drug cocktail, but suppressed the growth of tumor cells more efficiently than non-targeted Co-PS. Ex vivo imaging biodistribution studies revealed that FA-targeted Co-PS led to highly efficient targeting and accumulation in the BEL-7404 xenograft tumor. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of polymersomes to BEL-7404 tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In our study, novel folate-targeted co-delivery polymersomes (Co-PS) were successfully developed to encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (paclitaxel and doxorubicin) into the different compartments of the vesicle. In vivo studies revealed that the combination chemotherapy of polymersomes to BEL-7404 xenograft tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2017.06.017</identifier><identifier>PMID: 28627436</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ammonium ; Ammonium sulfate ; Animals ; Biocompatibility ; Block copolymers ; Cancer ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Chemotherapy ; Co-delivery ; Combination chemotherapy ; Compartments ; Copolymers ; Cytotoxicity ; Doxorubicin ; Doxorubicin - chemistry ; Doxorubicin - pharmacokinetics ; Doxorubicin - pharmacology ; Drug development ; Drugs ; Encapsulation ; Folate-receptor targeted ; Folic acid ; Folic Acid - chemistry ; Folic Acid - pharmacokinetics ; Folic Acid - pharmacology ; Group dynamics ; Growth inhibition ; Hepatocellular carcinoma ; Humans ; Hydrophilic surfaces ; Hydrophobic surfaces ; Hydrophobicity ; In vitro methods and tests ; In vivo methods and tests ; Inhibition ; Injection ; Internalization ; Intravenous administration ; Lamellar structure ; Liver Neoplasms - drug therapy ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Mice, Inbred BALB C ; Mice, Nude ; Paclitaxel ; Paclitaxel - chemistry ; Paclitaxel - pharmacokinetics ; Paclitaxel - pharmacology ; Pharmacokinetics ; Pharmacology ; Polymersomes ; Self-assembly ; Sulfates ; Toxicity ; Tumor cells ; Tumors ; Xenograft Model Antitumor Assays ; Xenografts</subject><ispartof>Acta biomaterialia, 2017-08, Vol.58, p.399-412</ispartof><rights>2017 Acta Materialia Inc.</rights><rights>Copyright © 2017 Acta Materialia Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Aug 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-367b87f635b8aeabb5c00d30bcf492520cd7ffffb12176d0fb4edfe5cc8315023</citedby><cites>FETCH-LOGICAL-c390t-367b87f635b8aeabb5c00d30bcf492520cd7ffffb12176d0fb4edfe5cc8315023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2017.06.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28627436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Dunwan</creatorcontrib><creatorcontrib>Wu, Shengjie</creatorcontrib><creatorcontrib>Hu, Chunyan</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Wang, Hai</creatorcontrib><creatorcontrib>Fan, Fan</creatorcontrib><creatorcontrib>Qin, Yu</creatorcontrib><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Sun, Hongfan</creatorcontrib><creatorcontrib>Leng, Xigang</creatorcontrib><creatorcontrib>Kong, Deling</creatorcontrib><creatorcontrib>Zhang, Linhua</creatorcontrib><title>Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bilayered lamellar structure were successfully developed to co-encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (PTX and DOX) in a single vesicle for enhancing the combination chemotherapeutic effect. Hydrophobic PTX was loaded into the thick hydrophobic lamellar membrane by the self-assembly of triblock copolymer PCL8000-PEG8000-PCL8000, while hydrophilic DOX was encapsulated into the hydrophilic reservoir using a trans-membrane ammonium sulfate gradient method. In vitro release study indicated that the drugs were released from the polymersomes in a controlled and sustained manner. Cellular uptake study indicated that FA-targeted Co-PS had higher internalization efficiency in FA receptor-overexpressing BEL-7404 cells than non-targeted Co-PS. In vitro cytotoxicity assay demonstrated that FA-targeted Co-PS exhibited less cytotoxic effect than free drug cocktail, but suppressed the growth of tumor cells more efficiently than non-targeted Co-PS. Ex vivo imaging biodistribution studies revealed that FA-targeted Co-PS led to highly efficient targeting and accumulation in the BEL-7404 xenograft tumor. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of polymersomes to BEL-7404 tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In our study, novel folate-targeted co-delivery polymersomes (Co-PS) were successfully developed to encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (paclitaxel and doxorubicin) into the different compartments of the vesicle. In vivo studies revealed that the combination chemotherapy of polymersomes to BEL-7404 xenograft tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.</description><subject>Ammonium</subject><subject>Ammonium sulfate</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Block copolymers</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Co-delivery</subject><subject>Combination chemotherapy</subject><subject>Compartments</subject><subject>Copolymers</subject><subject>Cytotoxicity</subject><subject>Doxorubicin</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Encapsulation</subject><subject>Folate-receptor targeted</subject><subject>Folic acid</subject><subject>Folic Acid - chemistry</subject><subject>Folic Acid - pharmacokinetics</subject><subject>Folic Acid - pharmacology</subject><subject>Group dynamics</subject><subject>Growth inhibition</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Hydrophilic surfaces</subject><subject>Hydrophobic surfaces</subject><subject>Hydrophobicity</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Inhibition</subject><subject>Injection</subject><subject>Internalization</subject><subject>Intravenous administration</subject><subject>Lamellar structure</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Paclitaxel</subject><subject>Paclitaxel - chemistry</subject><subject>Paclitaxel - pharmacokinetics</subject><subject>Paclitaxel - pharmacology</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Polymersomes</subject><subject>Self-assembly</subject><subject>Sulfates</subject><subject>Toxicity</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhQtRnHH0DUQCbtxUmaSqkvRGkMFRYcCNrkN-buw0VXXLJOVMP4DvbZoeXbgwi5wQvnNyyWmal4x2jDLx9tAZV2zEjlMmOyq6Ko-aS6akauUo1ON6lgNvJRXsonmW84HSXjGunjYXXAkuh15cNr9ucDIF2mLSdyjgyYrTcYaUcYZMJjS-3t3FsicW67YaN8Vi7mEiZvHE4z2mzUYXFxIwkbIH4nC2cTEl4kLcHuZqg2TWI8FA9rCagg6maZtMIs6k6sTZPG-eBDNlePGgV823mw9frz-1t18-fr5-f9u6fkdL2wtplQyiH60yYKwdHaW-p9aFYcdHTp2XoS7LOJPC02AH8AFG51TPRsr7q-bNOXdN-GODXPQc82kcswBuWbMdY5zumJQVff0PesAtLXW6Sg3DKLhgp8DhTLmEOScIek1xNumoGdWnmvRBn2vSp5o0FbpKtb16CN_sDP6v6U8vFXh3BqD-xs8ISWcXYXHgYwJXtMf4_xd-AwvrqQ0</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Zhu, Dunwan</creator><creator>Wu, Shengjie</creator><creator>Hu, Chunyan</creator><creator>Chen, Zhuo</creator><creator>Wang, Hai</creator><creator>Fan, Fan</creator><creator>Qin, Yu</creator><creator>Wang, Chun</creator><creator>Sun, Hongfan</creator><creator>Leng, Xigang</creator><creator>Kong, Deling</creator><creator>Zhang, Linhua</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma</title><author>Zhu, Dunwan ; Wu, Shengjie ; Hu, Chunyan ; Chen, Zhuo ; Wang, Hai ; Fan, Fan ; Qin, Yu ; Wang, Chun ; Sun, Hongfan ; Leng, Xigang ; Kong, Deling ; Zhang, Linhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-367b87f635b8aeabb5c00d30bcf492520cd7ffffb12176d0fb4edfe5cc8315023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Ammonium</topic><topic>Ammonium sulfate</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Block copolymers</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Co-delivery</topic><topic>Combination chemotherapy</topic><topic>Compartments</topic><topic>Copolymers</topic><topic>Cytotoxicity</topic><topic>Doxorubicin</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug development</topic><topic>Drugs</topic><topic>Encapsulation</topic><topic>Folate-receptor targeted</topic><topic>Folic acid</topic><topic>Folic Acid - chemistry</topic><topic>Folic Acid - pharmacokinetics</topic><topic>Folic Acid - pharmacology</topic><topic>Group dynamics</topic><topic>Growth inhibition</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Hydrophilic surfaces</topic><topic>Hydrophobic surfaces</topic><topic>Hydrophobicity</topic><topic>In vitro methods and tests</topic><topic>In vivo methods and tests</topic><topic>Inhibition</topic><topic>Injection</topic><topic>Internalization</topic><topic>Intravenous administration</topic><topic>Lamellar structure</topic><topic>Liver Neoplasms - 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Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Dunwan</au><au>Wu, Shengjie</au><au>Hu, Chunyan</au><au>Chen, Zhuo</au><au>Wang, Hai</au><au>Fan, Fan</au><au>Qin, Yu</au><au>Wang, Chun</au><au>Sun, Hongfan</au><au>Leng, Xigang</au><au>Kong, Deling</au><au>Zhang, Linhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2017-08</date><risdate>2017</risdate><volume>58</volume><spage>399</spage><epage>412</epage><pages>399-412</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bilayered lamellar structure were successfully developed to co-encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (PTX and DOX) in a single vesicle for enhancing the combination chemotherapeutic effect. Hydrophobic PTX was loaded into the thick hydrophobic lamellar membrane by the self-assembly of triblock copolymer PCL8000-PEG8000-PCL8000, while hydrophilic DOX was encapsulated into the hydrophilic reservoir using a trans-membrane ammonium sulfate gradient method. In vitro release study indicated that the drugs were released from the polymersomes in a controlled and sustained manner. Cellular uptake study indicated that FA-targeted Co-PS had higher internalization efficiency in FA receptor-overexpressing BEL-7404 cells than non-targeted Co-PS. In vitro cytotoxicity assay demonstrated that FA-targeted Co-PS exhibited less cytotoxic effect than free drug cocktail, but suppressed the growth of tumor cells more efficiently than non-targeted Co-PS. Ex vivo imaging biodistribution studies revealed that FA-targeted Co-PS led to highly efficient targeting and accumulation in the BEL-7404 xenograft tumor. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of polymersomes to BEL-7404 tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In our study, novel folate-targeted co-delivery polymersomes (Co-PS) were successfully developed to encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (paclitaxel and doxorubicin) into the different compartments of the vesicle. In vivo studies revealed that the combination chemotherapy of polymersomes to BEL-7404 xenograft tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28627436</pmid><doi>10.1016/j.actbio.2017.06.017</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2017-08, Vol.58, p.399-412 |
| issn | 1742-7061 1878-7568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1911209177 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Ammonium Ammonium sulfate Animals Biocompatibility Block copolymers Cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Chemotherapy Co-delivery Combination chemotherapy Compartments Copolymers Cytotoxicity Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug development Drugs Encapsulation Folate-receptor targeted Folic acid Folic Acid - chemistry Folic Acid - pharmacokinetics Folic Acid - pharmacology Group dynamics Growth inhibition Hepatocellular carcinoma Humans Hydrophilic surfaces Hydrophobic surfaces Hydrophobicity In vitro methods and tests In vivo methods and tests Inhibition Injection Internalization Intravenous administration Lamellar structure Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice, Inbred BALB C Mice, Nude Paclitaxel Paclitaxel - chemistry Paclitaxel - pharmacokinetics Paclitaxel - pharmacology Pharmacokinetics Pharmacology Polymersomes Self-assembly Sulfates Toxicity Tumor cells Tumors Xenograft Model Antitumor Assays Xenografts |
| title | Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T06%3A52%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Folate-targeted%20polymersomes%20loaded%20with%20both%20paclitaxel%20and%20doxorubicin%20for%20the%20combination%20chemotherapy%20of%20hepatocellular%20carcinoma&rft.jtitle=Acta%20biomaterialia&rft.au=Zhu,%20Dunwan&rft.date=2017-08&rft.volume=58&rft.spage=399&rft.epage=412&rft.pages=399-412&rft.issn=1742-7061&rft.eissn=1878-7568&rft_id=info:doi/10.1016/j.actbio.2017.06.017&rft_dat=%3Cproquest_cross%3E1911209177%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1944562612&rft_id=info:pmid/28627436&rft_els_id=S174270611730380X&rfr_iscdi=true |