Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements

We developed and validated a novel hTERT/CMV promoter element-driven gene expression cassette that can robustly enhance cancer-specific gene expression. The following gene expressional elements were located in tandem within the plasmid construct: [hTERT core promoter, cytomegalovirus (CMV) minimized...

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Veröffentlicht in:	Oncology reports 2017-08, Vol.38 (2), p.1108-1114
Hauptverfasser:	Sakaguchi, Masakiyo, Sadahira, Takuya, Ueki, Hideo, Kinoshita, Rie, Murata, Hitoshi, Yamamoto, Ken-Ichi, Futami, Junichiro, Nasu, Yasutomo, Ochiai, Kazuhiko, Kumon, Hiromi, Huh, Nam-Ho, Watanabe, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Bladder cancer cancer Carcinogenesis Cytomegalovirus Cytomegalovirus - genetics cytomegalovirus promoter enhancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic Vectors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Health aspects hTERT Humans Leukocytes, Mononuclear - metabolism Liver cancer Microscopy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Plasmids Promoter Regions, Genetic Promoters (Genetics) Regulatory Sequences, Nucleic Acid Telomerase Telomerase - genetics Tumor Cells, Cultured
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