Incomplete Loading of Sodium Lauryl Sulfate and Fasted State Simulated Intestinal Fluid Micelles Within the Diffusion Layers of Dispersed Drug Particles During Dissolution

Poorly water soluble drug candidates have been common in developmental pipelines over the last several decades. This has fueled considerable research around understanding how bile salt and model micelles can improve drug particle dissolution rates and human drug exposure levels. However, in the phar...

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Veröffentlicht in:Journal of pharmaceutical sciences 2018-01, Vol.107 (1), p.156-169
Hauptverfasser: Galipeau, Kendra, Socki, Michael, Socia, Adam, Harmon, Paul A.
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Sprache:eng
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