Protein kinase Cβ activates fat mass and obesity‐associated protein by influencing its ubiquitin/proteasome degradation

ABSTRACT Protein kinase Cβ (PKCβ) is a serine‐threonine kinase associated with obesity and diabetic complications; its activation contributes to weight gain, and deletion of its gene results in resistance to genetic‐ and diet‐induced obesity. Fat mass and obesity‐associated (FTO) protein is a recent...

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Veröffentlicht in:	The FASEB journal 2017-10, Vol.31 (10), p.4396-4406
Hauptverfasser:	Tai, Haoran, Wang, Xiaobo, Zhou, Jiao, Han, Xiaojuan, Fang, Tingting, Gong, Hui, Huang, Ning, Chen, Honghan, Qin, Jianqiong, Yang, Ming, Wei, Xiawei, Yang, Li, Xiao, Hengyi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Activation Adipogenesis Adipogenesis - genetics Animals Body fat Body weight Body weight gain Catalysis Cell differentiation Cell Differentiation - genetics Cell Differentiation - physiology Clonal deletion Complications Deactivation Degradation Diabetes mellitus FTO Gene deletion Humans Inactivation Kinases Leptin - metabolism Metabolic disorders Mice mTOR Obesity Obesity - metabolism Phosphorylation Proteasome Endopeptidase Complex - metabolism Proteasomes Protein kinase Protein kinase C Protein Kinase C beta - genetics Protein Kinase C beta - metabolism Protein-serine/threonine kinase Proteins Ribonucleic acid RNA Ubiquitin Ubiquitin - metabolism Up-Regulation
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