An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

A naphthalimide-based two-photon probe (AHGa) for the detection of cell senescence is designed. The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galactose bonded to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-07, Vol.139 (26), p.8808-8811
Hauptverfasser:	Lozano-Torres, Beatriz, Galiana, Irene, Rovira, Miguel, Garrido, Eva, Chaib, Selim, Bernardos, Andrea, Muñoz-Espín, Daniel, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cellular Senescence - drug effects Fluorescent Dyes - chemistry Humans Mice Naphthalimides - chemistry Neoplasms - drug therapy Photons Reference Standards Xenograft Model Antitumor Assays
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