Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines

Mammary tumorigenesis can be modulated by melatonin, which has oncostatic action mediated by multiple mechanisms, including the inhibition of the activity of transcription factors such as NF-κB and modulation of interleukins (ILs) expression. IL-25 is an active cytokine that induces apoptosis in tum...

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Veröffentlicht in:	Life sciences (1973) 2017-08, Vol.183, p.98-109
Hauptverfasser:	Gelaleti, Gabriela Bottaro, Borin, Thaiz Ferraz, Maschio-Signorini, Larissa Bazela, Moschetta, Marina Gobbe, Jardim-Perassi, Bruna Victorasso, Calvinho, Guilherme Berto, Facchini, Mariana Castilho, Viloria-Petit, Alicia M., de Campos Zuccari, Debora Aparecida Pires
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Apoptosis - physiology Biotechnology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Caspase Caspase-3 Cell Line, Tumor Cell Survival - physiology Cytokines Female Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Neoplastic Humans Immunofluorescence Insulin-like growth factor I Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 5 Interleukin-17 - administration & dosage Interleukin-17 - metabolism Interleukin-17B Interleukin-17E Interleukin-25 Interleukins Melatonin Melatonin - administration & dosage Melatonin - metabolism Melatonin - pharmacology Metastases Monolayers Neovascularization, Pathologic - metabolism p53 Protein Polymerase Chain Reaction Protein expression Proteins Quantitative analysis Receptors, Interleukin - metabolism Signal Transduction - physiology Transcription factors Tumor cell lines Tumor cells Tumorigenesis Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics VEGF XIAP protein
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