A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids
[Display omitted] Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for...
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| Veröffentlicht in: | International journal of pharmaceutics 2017-08, Vol.528 (1-2), p.586-594 |
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| container_end_page | 594 |
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| container_issue | 1-2 |
| container_start_page | 586 |
| container_title | International journal of pharmaceutics |
| container_volume | 528 |
| creator | da Silva, Jéssica Bassi Khutoryanskiy, Vitaliy V. Bruschi, Marcos L. Cook, Michael T. |
| description | [Display omitted]
Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type. |
| doi_str_mv | 10.1016/j.ijpharm.2017.06.025 |
| format | Article |
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Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2017.06.025</identifier><identifier>PMID: 28624662</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animal Testing Alternatives ; Biomimetic ; Biomimetic Materials - chemistry ; Hydrogels - chemistry ; Mouth Mucosa ; Mucoadhesion ; Mucosal drug delivery ; Semi-solid dosage forms ; Soft matter ; Tablets ; Technology, Pharmaceutical</subject><ispartof>International journal of pharmaceutics, 2017-08, Vol.528 (1-2), p.586-594</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-936f808b12a8b99176aa510b17ae065a0045da72024ac83771c5b4c7281cbde23</citedby><cites>FETCH-LOGICAL-c412t-936f808b12a8b99176aa510b17ae065a0045da72024ac83771c5b4c7281cbde23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2017.06.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28624662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, Jéssica Bassi</creatorcontrib><creatorcontrib>Khutoryanskiy, Vitaliy V.</creatorcontrib><creatorcontrib>Bruschi, Marcos L.</creatorcontrib><creatorcontrib>Cook, Michael T.</creatorcontrib><title>A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.</description><subject>Animal Testing Alternatives</subject><subject>Biomimetic</subject><subject>Biomimetic Materials - chemistry</subject><subject>Hydrogels - chemistry</subject><subject>Mouth Mucosa</subject><subject>Mucoadhesion</subject><subject>Mucosal drug delivery</subject><subject>Semi-solid dosage forms</subject><subject>Soft matter</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1P6zAQtBAIysdPAOXIJWHXSWznhBB6D5CQOABny3E21FVcFztF4t-T0sKV00o7Mzuzw9g5QoGA4mpRuMVqbqIvOKAsQBTA6z02QyXLvKyk2GczKKXKa5TlETtOaQEAgmN5yI64ErwSgs_Y803m1zYkk3vnaXQ282ak6MyQ9SFm45y-cdPNKbmwzEZKo1u-ZaHfYNGHNxqGzSKRd3kKg-vSKTvozZDobDdP2Ov_fy-39_nj093D7c1jbivkY96UolegWuRGtU2DUhhTI7QoDYGoDUBVd0Zy4JWxqpQSbd1WVnKFtu2Ilyfscnt3FcP7egqmvUt2ymOWFNZJY4OIjVK8nqj1lmpjSClSr1fReRM_NYLe9KkXeten3vSpQWj41l3sLNatp-5X9VPgRLjeEmh69MNR1Mk6WlrqXCQ76i64Pyy-AN_NiWg</recordid><startdate>20170807</startdate><enddate>20170807</enddate><creator>da Silva, Jéssica Bassi</creator><creator>Khutoryanskiy, Vitaliy V.</creator><creator>Bruschi, Marcos L.</creator><creator>Cook, Michael T.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170807</creationdate><title>A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids</title><author>da Silva, Jéssica Bassi ; Khutoryanskiy, Vitaliy V. ; Bruschi, Marcos L. ; Cook, Michael T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-936f808b12a8b99176aa510b17ae065a0045da72024ac83771c5b4c7281cbde23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal Testing Alternatives</topic><topic>Biomimetic</topic><topic>Biomimetic Materials - chemistry</topic><topic>Hydrogels - chemistry</topic><topic>Mouth Mucosa</topic><topic>Mucoadhesion</topic><topic>Mucosal drug delivery</topic><topic>Semi-solid dosage forms</topic><topic>Soft matter</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva, Jéssica Bassi</creatorcontrib><creatorcontrib>Khutoryanskiy, Vitaliy V.</creatorcontrib><creatorcontrib>Bruschi, Marcos L.</creatorcontrib><creatorcontrib>Cook, Michael T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, Jéssica Bassi</au><au>Khutoryanskiy, Vitaliy V.</au><au>Bruschi, Marcos L.</au><au>Cook, Michael T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2017-08-07</date><risdate>2017</risdate><volume>528</volume><issue>1-2</issue><spage>586</spage><epage>594</epage><pages>586-594</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28624662</pmid><doi>10.1016/j.ijpharm.2017.06.025</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2017-08, Vol.528 (1-2), p.586-594 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1911198825 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animal Testing Alternatives Biomimetic Biomimetic Materials - chemistry Hydrogels - chemistry Mouth Mucosa Mucoadhesion Mucosal drug delivery Semi-solid dosage forms Soft matter Tablets Technology, Pharmaceutical |
| title | A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids |
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