A Combination of Three Repurposed Drugs Administered at Reperfusion as a Promising Therapy for Postischemic Brain Injury

Cerebral ischemia leads to multifaceted injury to the brain. A polytherapeutic drug that can be administered immediately after reperfusion may increase protection to the brain by simultaneously targeting multiple deleterious cascades. This study evaluated efficacy of the combination of three clinica...

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Veröffentlicht in:	Translational stroke research 2017-12, Vol.8 (6), p.560-577
Hauptverfasser:	Yu, I-Chen, Kuo, Ping-Chang, Yen, Jui-Hung, Paraiso, Hallel C., Curfman, Eric T., Hong-Goka, Benecia C., Sweazey, Robert D., Chang, Fen-Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Brain - drug effects Brain Ischemia - drug therapy Cardiac arrest Cardiology Carotid arteries Drug dosages Drug Therapy, Combination FDA approval Female Ischemia Laboratory animals Lasers Lovastatin - administration & dosage Mice Mice, Inbred C57BL Minocycline - administration & dosage Neurology Neurons - drug effects Neuroprotective Agents - administration & dosage Neurosciences Neurosurgery Original Article Reperfusion Injury - drug therapy Statins Stroke Surgery Toxicity Traumatic brain injury Triazines - administration & dosage Vascular Surgery Veins & arteries
Online-Zugang:	Volltext
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