Endothelial vascular markers in coronary surgery
Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/C...
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| Veröffentlicht in: | Heart and vessels 2017-11, Vol.32 (11), p.1390-1399 |
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| creator | Valencia-Nuñez, Diana M. Kreutler, Willy Moya-Gonzalez, Javier Alados-Arboledas, Pedro Muñoz-Carvajal, Ignacio Carmona, Andrés Ramirez-Chamond, Rafael Carracedo-Añon, Julia |
| description | Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/CD133/CD34), essential for endothelial repair, and of endothelial microvesicles (CD31/annexin V) as indicators of endothelial lesion, in patients undergoing coronary bypass surgery with respect both to baseline levels and to counts in healthy subjects. In an observational descriptive study, 31 patients scheduled for coronary revascularization surgery were compared with those of 25 healthy controls. In a subsequent longitudinal study, patients undergoing surgery were monitored at 5 timepoints up until 48 h after surgery. Endothelial progenitor cell (VEGFR2/CD133/CD34) and endothelial microvesicle (CD31/annexin V) levels were quantified by flow cytometry. Baseline endothelial progenitor cell counts in coronary patients were significantly lower than those of healthy controls (
p
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| doi_str_mv | 10.1007/s00380-017-1006-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1910800725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1954557293</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-1c4439dbdd038844d48157211dff82c917e9d011b512ae0c4964a86ae970bd0a3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_gBdZ8OIlOpOP3eQopX5AwYueQ3aT1dbtbk26Qv-9KVtFBE9hyDPvzDyEnCNcI0BxEwG4AgpY0FTnlB-QMeYoKZMFPyRj0AhUcVaMyEmMSwCUGvUxGTGVM861GhOYta7bvPlmYZvs08aqb2zIVja8-xCzRZtVXehaG7ZZ7MOrD9tTclTbJvqz_TshL3ez5-kDnT_dP05v57TiOt9QrITg2pXOpRWVEE4olAVDdHWtWKWx8NoBYimRWQ-V0LmwKrdeF1A6sHxCrobcdeg-eh83ZrWIlW8a2_qujwbTbSpJYDKhl3_QZdeHNm2XKClkmqt5onCgqtDFGHxt1mGRDt0aBLPTaQadJunc1bnZ9Vzsk_ty5d1Px7e_BLABiOmrTX5-jf439QsCc32r</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1954557293</pqid></control><display><type>article</type><title>Endothelial vascular markers in coronary surgery</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Valencia-Nuñez, Diana M. ; Kreutler, Willy ; Moya-Gonzalez, Javier ; Alados-Arboledas, Pedro ; Muñoz-Carvajal, Ignacio ; Carmona, Andrés ; Ramirez-Chamond, Rafael ; Carracedo-Añon, Julia</creator><creatorcontrib>Valencia-Nuñez, Diana M. ; Kreutler, Willy ; Moya-Gonzalez, Javier ; Alados-Arboledas, Pedro ; Muñoz-Carvajal, Ignacio ; Carmona, Andrés ; Ramirez-Chamond, Rafael ; Carracedo-Añon, Julia</creatorcontrib><description>Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/CD133/CD34), essential for endothelial repair, and of endothelial microvesicles (CD31/annexin V) as indicators of endothelial lesion, in patients undergoing coronary bypass surgery with respect both to baseline levels and to counts in healthy subjects. In an observational descriptive study, 31 patients scheduled for coronary revascularization surgery were compared with those of 25 healthy controls. In a subsequent longitudinal study, patients undergoing surgery were monitored at 5 timepoints up until 48 h after surgery. Endothelial progenitor cell (VEGFR2/CD133/CD34) and endothelial microvesicle (CD31/annexin V) levels were quantified by flow cytometry. Baseline endothelial progenitor cell counts in coronary patients were significantly lower than those of healthy controls (
p
< 0.001); however, after surgery, levels rose steadily over all 5 timepoints to 48 h with statistically significant differences (
p
< 0.001) between intra-operative and 48 h after surgery (T5). Endothelial microvesicle levels were significantly higher in coronary patients prior to surgery than in healthy controls (
p
< 0.001), and despite declining at 48 h remained significantly higher than those of controls (
p
< 0.001). Coronary surgery has had a positive impact on the endothelium in the patients, prompting a decrease in signs of endothelial dysfunction and a considerable improvement in the endothelial repair mechanisms involved in angiogenesis, playing an important role in the inflammatory response and the remodelling process of ischemic myocardium in postoperative period.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-017-1006-3</identifier><identifier>PMID: 28623398</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Angiogenesis ; Annexin V ; Annexins - blood ; Arteriosclerosis ; Atherosclerosis ; Biomarkers - blood ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; CD34 antigen ; Cell-Derived Microparticles - metabolism ; Cell-Derived Microparticles - pathology ; Cells (biology) ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - physiopathology ; Coronary Artery Disease - surgery ; Coronary Vessels - metabolism ; Coronary Vessels - physiopathology ; Coronary Vessels - surgery ; Correlation analysis ; Cytometry ; Endothelial Progenitor Cells - metabolism ; Endothelial Progenitor Cells - pathology ; Endothelium ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Flow Cytometry ; Follow-Up Studies ; Heart ; Heart diseases ; Heart surgery ; Humans ; Inflammation ; Inflammatory response ; Ischemia ; Medicine ; Medicine & Public Health ; Morbidity ; Myocardial Revascularization ; Myocardium ; Original Article ; Patients ; Postoperative Period ; Progenitor cells ; Prognosis ; Prospective Studies ; Repair ; Statistical analysis ; Stem cells ; Surgery ; Vascular Surgery ; Vasodilation - physiology</subject><ispartof>Heart and vessels, 2017-11, Vol.32 (11), p.1390-1399</ispartof><rights>Springer Japan KK 2017</rights><rights>Heart and Vessels is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-1c4439dbdd038844d48157211dff82c917e9d011b512ae0c4964a86ae970bd0a3</citedby><cites>FETCH-LOGICAL-c396t-1c4439dbdd038844d48157211dff82c917e9d011b512ae0c4964a86ae970bd0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-017-1006-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-017-1006-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28623398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valencia-Nuñez, Diana M.</creatorcontrib><creatorcontrib>Kreutler, Willy</creatorcontrib><creatorcontrib>Moya-Gonzalez, Javier</creatorcontrib><creatorcontrib>Alados-Arboledas, Pedro</creatorcontrib><creatorcontrib>Muñoz-Carvajal, Ignacio</creatorcontrib><creatorcontrib>Carmona, Andrés</creatorcontrib><creatorcontrib>Ramirez-Chamond, Rafael</creatorcontrib><creatorcontrib>Carracedo-Añon, Julia</creatorcontrib><title>Endothelial vascular markers in coronary surgery</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/CD133/CD34), essential for endothelial repair, and of endothelial microvesicles (CD31/annexin V) as indicators of endothelial lesion, in patients undergoing coronary bypass surgery with respect both to baseline levels and to counts in healthy subjects. In an observational descriptive study, 31 patients scheduled for coronary revascularization surgery were compared with those of 25 healthy controls. In a subsequent longitudinal study, patients undergoing surgery were monitored at 5 timepoints up until 48 h after surgery. Endothelial progenitor cell (VEGFR2/CD133/CD34) and endothelial microvesicle (CD31/annexin V) levels were quantified by flow cytometry. Baseline endothelial progenitor cell counts in coronary patients were significantly lower than those of healthy controls (
p
< 0.001); however, after surgery, levels rose steadily over all 5 timepoints to 48 h with statistically significant differences (
p
< 0.001) between intra-operative and 48 h after surgery (T5). Endothelial microvesicle levels were significantly higher in coronary patients prior to surgery than in healthy controls (
p
< 0.001), and despite declining at 48 h remained significantly higher than those of controls (
p
< 0.001). Coronary surgery has had a positive impact on the endothelium in the patients, prompting a decrease in signs of endothelial dysfunction and a considerable improvement in the endothelial repair mechanisms involved in angiogenesis, playing an important role in the inflammatory response and the remodelling process of ischemic myocardium in postoperative period.</description><subject>Angiogenesis</subject><subject>Annexin V</subject><subject>Annexins - blood</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>CD34 antigen</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cell-Derived Microparticles - pathology</subject><subject>Cells (biology)</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary Vessels - metabolism</subject><subject>Coronary Vessels - physiopathology</subject><subject>Coronary Vessels - surgery</subject><subject>Correlation analysis</subject><subject>Cytometry</subject><subject>Endothelial Progenitor Cells - metabolism</subject><subject>Endothelial Progenitor Cells - pathology</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Flow Cytometry</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Myocardial Revascularization</subject><subject>Myocardium</subject><subject>Original Article</subject><subject>Patients</subject><subject>Postoperative Period</subject><subject>Progenitor cells</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Repair</subject><subject>Statistical analysis</subject><subject>Stem cells</subject><subject>Surgery</subject><subject>Vascular Surgery</subject><subject>Vasodilation - 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blood</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>CD34 antigen</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Cell-Derived Microparticles - pathology</topic><topic>Cells (biology)</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary Vessels - metabolism</topic><topic>Coronary Vessels - physiopathology</topic><topic>Coronary Vessels - surgery</topic><topic>Correlation analysis</topic><topic>Cytometry</topic><topic>Endothelial Progenitor Cells - metabolism</topic><topic>Endothelial Progenitor Cells - pathology</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Flow Cytometry</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Myocardial Revascularization</topic><topic>Myocardium</topic><topic>Original Article</topic><topic>Patients</topic><topic>Postoperative Period</topic><topic>Progenitor cells</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Repair</topic><topic>Statistical analysis</topic><topic>Stem cells</topic><topic>Surgery</topic><topic>Vascular Surgery</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valencia-Nuñez, Diana M.</creatorcontrib><creatorcontrib>Kreutler, Willy</creatorcontrib><creatorcontrib>Moya-Gonzalez, Javier</creatorcontrib><creatorcontrib>Alados-Arboledas, Pedro</creatorcontrib><creatorcontrib>Muñoz-Carvajal, Ignacio</creatorcontrib><creatorcontrib>Carmona, Andrés</creatorcontrib><creatorcontrib>Ramirez-Chamond, Rafael</creatorcontrib><creatorcontrib>Carracedo-Añon, Julia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valencia-Nuñez, Diana M.</au><au>Kreutler, Willy</au><au>Moya-Gonzalez, Javier</au><au>Alados-Arboledas, Pedro</au><au>Muñoz-Carvajal, Ignacio</au><au>Carmona, Andrés</au><au>Ramirez-Chamond, Rafael</au><au>Carracedo-Añon, Julia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial vascular markers in coronary surgery</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>32</volume><issue>11</issue><spage>1390</spage><epage>1399</epage><pages>1390-1399</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/CD133/CD34), essential for endothelial repair, and of endothelial microvesicles (CD31/annexin V) as indicators of endothelial lesion, in patients undergoing coronary bypass surgery with respect both to baseline levels and to counts in healthy subjects. In an observational descriptive study, 31 patients scheduled for coronary revascularization surgery were compared with those of 25 healthy controls. In a subsequent longitudinal study, patients undergoing surgery were monitored at 5 timepoints up until 48 h after surgery. Endothelial progenitor cell (VEGFR2/CD133/CD34) and endothelial microvesicle (CD31/annexin V) levels were quantified by flow cytometry. Baseline endothelial progenitor cell counts in coronary patients were significantly lower than those of healthy controls (
p
< 0.001); however, after surgery, levels rose steadily over all 5 timepoints to 48 h with statistically significant differences (
p
< 0.001) between intra-operative and 48 h after surgery (T5). Endothelial microvesicle levels were significantly higher in coronary patients prior to surgery than in healthy controls (
p
< 0.001), and despite declining at 48 h remained significantly higher than those of controls (
p
< 0.001). Coronary surgery has had a positive impact on the endothelium in the patients, prompting a decrease in signs of endothelial dysfunction and a considerable improvement in the endothelial repair mechanisms involved in angiogenesis, playing an important role in the inflammatory response and the remodelling process of ischemic myocardium in postoperative period.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>28623398</pmid><doi>10.1007/s00380-017-1006-3</doi><tpages>10</tpages></addata></record> |
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| ispartof | Heart and vessels, 2017-11, Vol.32 (11), p.1390-1399 |
| issn | 0910-8327 1615-2573 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Angiogenesis Annexin V Annexins - blood Arteriosclerosis Atherosclerosis Biomarkers - blood Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Cardiovascular disease Cardiovascular diseases CD34 antigen Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Cells (biology) Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - physiopathology Coronary Artery Disease - surgery Coronary Vessels - metabolism Coronary Vessels - physiopathology Coronary Vessels - surgery Correlation analysis Cytometry Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Flow Cytometry Follow-Up Studies Heart Heart diseases Heart surgery Humans Inflammation Inflammatory response Ischemia Medicine Medicine & Public Health Morbidity Myocardial Revascularization Myocardium Original Article Patients Postoperative Period Progenitor cells Prognosis Prospective Studies Repair Statistical analysis Stem cells Surgery Vascular Surgery Vasodilation - physiology |
| title | Endothelial vascular markers in coronary surgery |
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