Notch: an interactive player in neurogenesis and disease
Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. D...
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| Veröffentlicht in: | Cell and tissue research 2018-01, Vol.371 (1), p.73-89 |
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| creator | Zhang, Runrui Engler, Anna Taylor, Verdon |
| description | Notch signaling is evolutionarily conserved from
Drosophila
to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders. |
| doi_str_mv | 10.1007/s00441-017-2641-9 |
| format | Article |
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Drosophila
to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notch signaling is involved in many neurodegenerative diseases and brain disorders. Here, we summarize the fundamental role of Notch in neuronal development and specification and discuss how epigenetic regulation and pathway cross-talk contribute to Notch function. In addition, we cover aberrant alterations of Notch signaling in the diseased brain. The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-017-2641-9</identifier><identifier>PMID: 28620760</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Brain tumors ; Deregulation ; Drosophila ; Embryos ; Epigenetic inheritance ; Fruit flies ; Human Genetics ; Molecular Medicine ; Multimedia industry ; Neural stem cells ; Neurodegeneration ; Neurodegenerative diseases ; Neurogenesis ; Neurons ; Notch protein ; Proteomics ; Review ; Stem cells</subject><ispartof>Cell and tissue research, 2018-01, Vol.371 (1), p.73-89</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Cell and Tissue Research is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-8c72c10fd00e62797eee24ac295053c89c9d53c9fc2c0067824d7b723210c5763</citedby><cites>FETCH-LOGICAL-c584t-8c72c10fd00e62797eee24ac295053c89c9d53c9fc2c0067824d7b723210c5763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-017-2641-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-017-2641-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28620760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Runrui</creatorcontrib><creatorcontrib>Engler, Anna</creatorcontrib><creatorcontrib>Taylor, Verdon</creatorcontrib><title>Notch: an interactive player in neurogenesis and disease</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Notch signaling is evolutionarily conserved from
Drosophila
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The aim of this review is to provide an insight into how Notch signaling works in different contexts to control neurogenesis and its potential effects in diagnoses and therapies of neurodegeneration, brain tumors and disorders.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain tumors</subject><subject>Deregulation</subject><subject>Drosophila</subject><subject>Embryos</subject><subject>Epigenetic inheritance</subject><subject>Fruit flies</subject><subject>Human Genetics</subject><subject>Molecular Medicine</subject><subject>Multimedia industry</subject><subject>Neural stem cells</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Notch protein</subject><subject>Proteomics</subject><subject>Review</subject><subject>Stem cells</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVtLJDEQhYOsrKPuD_BFGhbEl9ZKujuXfRvEG4i-rOBbiOnqmUhPMibdgv_eDON6wyUPFSrfOZXiELJH4YgCiOMEUNe0BCpKxvNFbZAJrStWghTyB5lABawUnN9tke2UHgBozbn6SbaY5AwEhwmR12Gw8z-F8YXzA0ZjB_eExbI3zxhzq_A4xjBDj8mlTLVF6xKahLtkszN9wl-vdYfcnp3-Pbkor27OL0-mV6VtZD2U0gpmKXQtAHImlEBEVhvLVANNZaWyqs1VdZZZAC4kq1txL1jFKNhG8GqHHK59lzE8jpgGvXDJYt8bj2FMmioKMivrKqO_v6APYYw-_y5TsmKgmoa-UzPTo3a-C0PeemWqp02eKkUDKlNH31D5tLhwNnjsXO5_Ehx8EMzR9MM8hX4cXPDpM0jXoI0hpYidXka3MPFZU9CrWPU6Vp1j1atY9Uqz_7rZeL_A9k3xL8cMsDWQ8pOfYfyw-n9dXwAxRqfo</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Zhang, Runrui</creator><creator>Engler, Anna</creator><creator>Taylor, Verdon</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Notch: an interactive player in neurogenesis and disease</title><author>Zhang, Runrui ; Engler, Anna ; Taylor, Verdon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-8c72c10fd00e62797eee24ac295053c89c9d53c9fc2c0067824d7b723210c5763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain tumors</topic><topic>Deregulation</topic><topic>Drosophila</topic><topic>Embryos</topic><topic>Epigenetic inheritance</topic><topic>Fruit flies</topic><topic>Human Genetics</topic><topic>Molecular Medicine</topic><topic>Multimedia industry</topic><topic>Neural stem cells</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>Notch protein</topic><topic>Proteomics</topic><topic>Review</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Runrui</creatorcontrib><creatorcontrib>Engler, Anna</creatorcontrib><creatorcontrib>Taylor, Verdon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Runrui</au><au>Engler, Anna</au><au>Taylor, Verdon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Notch: an interactive player in neurogenesis and disease</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>371</volume><issue>1</issue><spage>73</spage><epage>89</epage><pages>73-89</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Notch signaling is evolutionarily conserved from
Drosophila
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| subjects | Biomedical and Life Sciences Biomedicine Brain tumors Deregulation Drosophila Embryos Epigenetic inheritance Fruit flies Human Genetics Molecular Medicine Multimedia industry Neural stem cells Neurodegeneration Neurodegenerative diseases Neurogenesis Neurons Notch protein Proteomics Review Stem cells |
| title | Notch: an interactive player in neurogenesis and disease |
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