The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride
The purpose of this study was to investigate the relationship between specific symptom severity and D 2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of s...
Gespeichert in:
| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2018-09, Vol.268 (6), p.529-540 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 540 |
|---|---|
| container_issue | 6 |
| container_start_page | 529 |
| container_title | European archives of psychiatry and clinical neuroscience |
| container_volume | 268 |
| creator | Joo, Yo-Han Kim, Jeong-Hee Son, Young-Don Kim, Hang-Keun Shin, Yeon-Jeong Lee, Sang-Yoon Kim, Jong-Hoon |
| description | The purpose of this study was to investigate the relationship between specific symptom severity and D
2/3
receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [
18
F]fallypride. For D
2/3
receptor availability, the binding potential with respect to non-displaceable compartment (BP
ND
) was derived using the simplified reference tissue model. The BP
ND
values were lower in patients on antipsychotic treatment than in controls across all regions with large effect sizes (1.03–1.42). The regions with the largest effect size were the substantia nigra, amygdala, and insula. Symptoms of schizophrenia were assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS). The region of interest-based analysis showed that PANSS excitement factor score had a significant positive correlation with the [
18
F]fallypride BP
ND
in the insula. The equivalent dose of antipsychotics was not significantly correlated with PANSS factor scores or regional BP
ND
values. The voxel-based analysis also revealed a significant positive association between the PANSS excitement factor and the [
18
F]fallypride BP
ND
in the insula. The present study revealed a significant association between excitement symptom severity and D
2/3
receptor availability in the insula in schizophrenia, suggesting a possible important role of D
2/3
receptor-mediated neurotransmission in the insula and related limbic system in the pathophysiology of this specific symptom cluster. |
| doi_str_mv | 10.1007/s00406-017-0821-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1910800522</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2086585493</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-f46df67e98a296592206c6840871d0c087672894d9933b7d690b1264b3f2cbe03</originalsourceid><addsrcrecordid>eNp1kd-K1TAQxosoeDz6AN4FvPGm7uRP08Q7WXfdhQW9OF6JhLSdbrO0aU3S3a2v5suZwxEEwathmO_3zQxfUbym8I4C1GcRQIAsgdYlKEbL7Umxo4LzUglNnxY70AJKyrl4XryI8Q4AaMVgV_w6DEgCjja52cfBLaTB9IDoCT62LuGEPpG4TUuaJxLxHoNLG7G-y_MUbEzB2WRH0s2LnZxH8pGd8WzYYiYCsffWjbZx45Fynix5T3aM5MGlgcR2cD_nZQjonX1PLBnc7VAGjPO4Hu8hXy4OJKa12076b1Rdfu_tOG5LcB2-LJ7lJuKrP3VffL28OJxflTefP12ff7gpWy50Knshu17WqJVlWlaaMZCtVAJUTTtoc5E1U1p0WnPe1J3U0FAmRcN71jYIfF-8PfkuYf6xYkxmcrHFcbQe5zUaqikogIqxLH3zj_RuXoPP1xkGSlaqEnnJvqAnVRvmGAP2Jv8z2bAZCuYYpznFaXKc5hin2TLDTkzMWn-L4a_z_6HfzQemTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2086585493</pqid></control><display><type>article</type><title>The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride</title><source>SpringerLink Journals - AutoHoldings</source><creator>Joo, Yo-Han ; Kim, Jeong-Hee ; Son, Young-Don ; Kim, Hang-Keun ; Shin, Yeon-Jeong ; Lee, Sang-Yoon ; Kim, Jong-Hoon</creator><creatorcontrib>Joo, Yo-Han ; Kim, Jeong-Hee ; Son, Young-Don ; Kim, Hang-Keun ; Shin, Yeon-Jeong ; Lee, Sang-Yoon ; Kim, Jong-Hoon</creatorcontrib><description>The purpose of this study was to investigate the relationship between specific symptom severity and D
2/3
receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [
18
F]fallypride. For D
2/3
receptor availability, the binding potential with respect to non-displaceable compartment (BP
ND
) was derived using the simplified reference tissue model. The BP
ND
values were lower in patients on antipsychotic treatment than in controls across all regions with large effect sizes (1.03–1.42). The regions with the largest effect size were the substantia nigra, amygdala, and insula. Symptoms of schizophrenia were assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS). The region of interest-based analysis showed that PANSS excitement factor score had a significant positive correlation with the [
18
F]fallypride BP
ND
in the insula. The equivalent dose of antipsychotics was not significantly correlated with PANSS factor scores or regional BP
ND
values. The voxel-based analysis also revealed a significant positive association between the PANSS excitement factor and the [
18
F]fallypride BP
ND
in the insula. The present study revealed a significant association between excitement symptom severity and D
2/3
receptor availability in the insula in schizophrenia, suggesting a possible important role of D
2/3
receptor-mediated neurotransmission in the insula and related limbic system in the pathophysiology of this specific symptom cluster.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-017-0821-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amygdala ; Antipsychotics ; Dopamine D2 receptors ; Image processing ; Limbic system ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Mental disorders ; Neurosciences ; Neurotransmission ; Original Paper ; Patients ; Positron emission tomography ; Psychiatry ; Psychotropic drugs ; Schizophrenia ; Substantia nigra</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2018-09, Vol.268 (6), p.529-540</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>European Archives of Psychiatry and Clinical Neuroscience is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-f46df67e98a296592206c6840871d0c087672894d9933b7d690b1264b3f2cbe03</citedby><cites>FETCH-LOGICAL-c349t-f46df67e98a296592206c6840871d0c087672894d9933b7d690b1264b3f2cbe03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-017-0821-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-017-0821-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Joo, Yo-Han</creatorcontrib><creatorcontrib>Kim, Jeong-Hee</creatorcontrib><creatorcontrib>Son, Young-Don</creatorcontrib><creatorcontrib>Kim, Hang-Keun</creatorcontrib><creatorcontrib>Shin, Yeon-Jeong</creatorcontrib><creatorcontrib>Lee, Sang-Yoon</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><title>The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>The purpose of this study was to investigate the relationship between specific symptom severity and D
2/3
receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [
18
F]fallypride. For D
2/3
receptor availability, the binding potential with respect to non-displaceable compartment (BP
ND
) was derived using the simplified reference tissue model. The BP
ND
values were lower in patients on antipsychotic treatment than in controls across all regions with large effect sizes (1.03–1.42). The regions with the largest effect size were the substantia nigra, amygdala, and insula. Symptoms of schizophrenia were assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS). The region of interest-based analysis showed that PANSS excitement factor score had a significant positive correlation with the [
18
F]fallypride BP
ND
in the insula. The equivalent dose of antipsychotics was not significantly correlated with PANSS factor scores or regional BP
ND
values. The voxel-based analysis also revealed a significant positive association between the PANSS excitement factor and the [
18
F]fallypride BP
ND
in the insula. The present study revealed a significant association between excitement symptom severity and D
2/3
receptor availability in the insula in schizophrenia, suggesting a possible important role of D
2/3
receptor-mediated neurotransmission in the insula and related limbic system in the pathophysiology of this specific symptom cluster.</description><subject>Amygdala</subject><subject>Antipsychotics</subject><subject>Dopamine D2 receptors</subject><subject>Image processing</subject><subject>Limbic system</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Neurosciences</subject><subject>Neurotransmission</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Psychiatry</subject><subject>Psychotropic drugs</subject><subject>Schizophrenia</subject><subject>Substantia nigra</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd-K1TAQxosoeDz6AN4FvPGm7uRP08Q7WXfdhQW9OF6JhLSdbrO0aU3S3a2v5suZwxEEwathmO_3zQxfUbym8I4C1GcRQIAsgdYlKEbL7Umxo4LzUglNnxY70AJKyrl4XryI8Q4AaMVgV_w6DEgCjja52cfBLaTB9IDoCT62LuGEPpG4TUuaJxLxHoNLG7G-y_MUbEzB2WRH0s2LnZxH8pGd8WzYYiYCsffWjbZx45Fynix5T3aM5MGlgcR2cD_nZQjonX1PLBnc7VAGjPO4Hu8hXy4OJKa12076b1Rdfu_tOG5LcB2-LJ7lJuKrP3VffL28OJxflTefP12ff7gpWy50Knshu17WqJVlWlaaMZCtVAJUTTtoc5E1U1p0WnPe1J3U0FAmRcN71jYIfF-8PfkuYf6xYkxmcrHFcbQe5zUaqikogIqxLH3zj_RuXoPP1xkGSlaqEnnJvqAnVRvmGAP2Jv8z2bAZCuYYpznFaXKc5hin2TLDTkzMWn-L4a_z_6HfzQemTg</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Joo, Yo-Han</creator><creator>Kim, Jeong-Hee</creator><creator>Son, Young-Don</creator><creator>Kim, Hang-Keun</creator><creator>Shin, Yeon-Jeong</creator><creator>Lee, Sang-Yoon</creator><creator>Kim, Jong-Hoon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride</title><author>Joo, Yo-Han ; Kim, Jeong-Hee ; Son, Young-Don ; Kim, Hang-Keun ; Shin, Yeon-Jeong ; Lee, Sang-Yoon ; Kim, Jong-Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-f46df67e98a296592206c6840871d0c087672894d9933b7d690b1264b3f2cbe03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amygdala</topic><topic>Antipsychotics</topic><topic>Dopamine D2 receptors</topic><topic>Image processing</topic><topic>Limbic system</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Neurosciences</topic><topic>Neurotransmission</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Psychiatry</topic><topic>Psychotropic drugs</topic><topic>Schizophrenia</topic><topic>Substantia nigra</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joo, Yo-Han</creatorcontrib><creatorcontrib>Kim, Jeong-Hee</creatorcontrib><creatorcontrib>Son, Young-Don</creatorcontrib><creatorcontrib>Kim, Hang-Keun</creatorcontrib><creatorcontrib>Shin, Yeon-Jeong</creatorcontrib><creatorcontrib>Lee, Sang-Yoon</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joo, Yo-Han</au><au>Kim, Jeong-Hee</au><au>Son, Young-Don</au><au>Kim, Hang-Keun</au><au>Shin, Yeon-Jeong</au><au>Lee, Sang-Yoon</au><au>Kim, Jong-Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><date>2018-09-01</date><risdate>2018</risdate><volume>268</volume><issue>6</issue><spage>529</spage><epage>540</epage><pages>529-540</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>The purpose of this study was to investigate the relationship between specific symptom severity and D
2/3
receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [
18
F]fallypride. For D
2/3
receptor availability, the binding potential with respect to non-displaceable compartment (BP
ND
) was derived using the simplified reference tissue model. The BP
ND
values were lower in patients on antipsychotic treatment than in controls across all regions with large effect sizes (1.03–1.42). The regions with the largest effect size were the substantia nigra, amygdala, and insula. Symptoms of schizophrenia were assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS). The region of interest-based analysis showed that PANSS excitement factor score had a significant positive correlation with the [
18
F]fallypride BP
ND
in the insula. The equivalent dose of antipsychotics was not significantly correlated with PANSS factor scores or regional BP
ND
values. The voxel-based analysis also revealed a significant positive association between the PANSS excitement factor and the [
18
F]fallypride BP
ND
in the insula. The present study revealed a significant association between excitement symptom severity and D
2/3
receptor availability in the insula in schizophrenia, suggesting a possible important role of D
2/3
receptor-mediated neurotransmission in the insula and related limbic system in the pathophysiology of this specific symptom cluster.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00406-017-0821-y</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-1334 |
| ispartof | European archives of psychiatry and clinical neuroscience, 2018-09, Vol.268 (6), p.529-540 |
| issn | 0940-1334 1433-8491 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1910800522 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Amygdala Antipsychotics Dopamine D2 receptors Image processing Limbic system Magnetic resonance imaging Medicine Medicine & Public Health Mental disorders Neurosciences Neurotransmission Original Paper Patients Positron emission tomography Psychiatry Psychotropic drugs Schizophrenia Substantia nigra |
| title | The relationship between excitement symptom severity and extrastriatal dopamine D2/3 receptor availability in patients with schizophrenia: a high-resolution PET study with [18F]fallypride |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A49%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relationship%20between%20excitement%20symptom%20severity%20and%20extrastriatal%20dopamine%20D2/3%20receptor%20availability%20in%20patients%20with%20schizophrenia:%20a%20high-resolution%20PET%20study%20with%20%5B18F%5Dfallypride&rft.jtitle=European%20archives%20of%20psychiatry%20and%20clinical%20neuroscience&rft.au=Joo,%20Yo-Han&rft.date=2018-09-01&rft.volume=268&rft.issue=6&rft.spage=529&rft.epage=540&rft.pages=529-540&rft.issn=0940-1334&rft.eissn=1433-8491&rft_id=info:doi/10.1007/s00406-017-0821-y&rft_dat=%3Cproquest_cross%3E2086585493%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2086585493&rft_id=info:pmid/&rfr_iscdi=true |