Rosai-Dorfman disease of vertebra: Case report and literature review
Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without lymphadenopathy. Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thor...
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| Veröffentlicht in: | Turkish journal of pediatrics 2016, Vol.58 (5), p.566-571 |
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| container_title | Turkish journal of pediatrics |
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| creator | Igrutinovic, Zoran Medovic, Rasa Markovic, Slavica Kostic, Gordana Raskovic, Zorica Tanaskovic-Nestorovic, Jelena Radovanovic, Marija Vuletic, Biljana |
| description | Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without lymphadenopathy. Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thoracic spine, with vertebral body fracture. A 14-year-old girl presented with cervical back pain for about one month as the only symptom. There was no lymphadenopathy. Results of laboratory tests were within reference ranges. The radiological examinations revealed collapse, osteolytic lesion and compressive fracture, which reduced vertical diameter of C4 vertebral body. The patient made a complete recovery after a limited C4 laminectomy, spondylodesis C3/C5 vertebra and biopsy of the lesion. Histologically, nonspecific cellular milieu and atypical histiocytic proliferation with emperipolesis, with CD68 and S100 positivity, confirmed a diagnosis of Rosai-Dorfman disease. Isolated extranodal skeletal Rosai-Dorfman disease should be considered among the differential diagnoses of similar changes, such as Langerhans cell histiocytosis, Erdheim-Cheister disease, eosinophilic granuloma, osteomyelitis, metastasis and lymphoma. |
| doi_str_mv | 10.24953/turkjped.2016.05.020 |
| format | Article |
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Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thoracic spine, with vertebral body fracture. A 14-year-old girl presented with cervical back pain for about one month as the only symptom. There was no lymphadenopathy. Results of laboratory tests were within reference ranges. The radiological examinations revealed collapse, osteolytic lesion and compressive fracture, which reduced vertical diameter of C4 vertebral body. The patient made a complete recovery after a limited C4 laminectomy, spondylodesis C3/C5 vertebra and biopsy of the lesion. Histologically, nonspecific cellular milieu and atypical histiocytic proliferation with emperipolesis, with CD68 and S100 positivity, confirmed a diagnosis of Rosai-Dorfman disease. Isolated extranodal skeletal Rosai-Dorfman disease should be considered among the differential diagnoses of similar changes, such as Langerhans cell histiocytosis, Erdheim-Cheister disease, eosinophilic granuloma, osteomyelitis, metastasis and lymphoma.</description><identifier>ISSN: 0041-4301</identifier><identifier>EISSN: 2791-6421</identifier><identifier>DOI: 10.24953/turkjped.2016.05.020</identifier><identifier>PMID: 28621104</identifier><language>eng</language><publisher>Turkey: Hacettepe University Faculty of Medicine</publisher><subject>Adolescent ; Back pain ; Biopsy ; Bone marrow ; Case reports ; Diagnosis, Differential ; Family medical history ; Female ; Histiocytosis, Sinus - diagnosis ; Histiocytosis, Sinus - surgery ; Humans ; Immunoglobulins ; Laboratories ; Laminectomy ; Literature reviews ; Sinuses ; Spinal cord ; Thoracic Vertebrae - pathology ; Thoracic Vertebrae - surgery ; Vertebrae</subject><ispartof>Turkish journal of pediatrics, 2016, Vol.58 (5), p.566-571</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Sep/Oct 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-9211c0921ea6596746915a736646b50d288c50fdcf1a39d39ee927bccdd232dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28621104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Igrutinovic, Zoran</creatorcontrib><creatorcontrib>Medovic, Rasa</creatorcontrib><creatorcontrib>Markovic, Slavica</creatorcontrib><creatorcontrib>Kostic, Gordana</creatorcontrib><creatorcontrib>Raskovic, Zorica</creatorcontrib><creatorcontrib>Tanaskovic-Nestorovic, Jelena</creatorcontrib><creatorcontrib>Radovanovic, Marija</creatorcontrib><creatorcontrib>Vuletic, Biljana</creatorcontrib><title>Rosai-Dorfman disease of vertebra: Case report and literature review</title><title>Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without lymphadenopathy. Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thoracic spine, with vertebral body fracture. A 14-year-old girl presented with cervical back pain for about one month as the only symptom. There was no lymphadenopathy. Results of laboratory tests were within reference ranges. The radiological examinations revealed collapse, osteolytic lesion and compressive fracture, which reduced vertical diameter of C4 vertebral body. The patient made a complete recovery after a limited C4 laminectomy, spondylodesis C3/C5 vertebra and biopsy of the lesion. Histologically, nonspecific cellular milieu and atypical histiocytic proliferation with emperipolesis, with CD68 and S100 positivity, confirmed a diagnosis of Rosai-Dorfman disease. Isolated extranodal skeletal Rosai-Dorfman disease should be considered among the differential diagnoses of similar changes, such as Langerhans cell histiocytosis, Erdheim-Cheister disease, eosinophilic granuloma, osteomyelitis, metastasis and lymphoma.</description><subject>Adolescent</subject><subject>Back pain</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Case reports</subject><subject>Diagnosis, Differential</subject><subject>Family medical history</subject><subject>Female</subject><subject>Histiocytosis, Sinus - diagnosis</subject><subject>Histiocytosis, Sinus - surgery</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Laboratories</subject><subject>Laminectomy</subject><subject>Literature reviews</subject><subject>Sinuses</subject><subject>Spinal cord</subject><subject>Thoracic Vertebrae - pathology</subject><subject>Thoracic Vertebrae - surgery</subject><subject>Vertebrae</subject><issn>0041-4301</issn><issn>2791-6421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkEtLAzEQgIMotlZ_grLgxcvWyXvjTVpfUBBEzyG7ycLWfZnsVvz3pra9eJmBmW8efAhdYpgTpji9HUb_ue6dnRPAYg58DgSO0JRIhVPBCD5GUwCGU0YBT9BZCGsAIkHJUzQhmSAYA5ui5VsXTJUuO182pk1sFZwJLunKZOP84HJv7pLFtuJd3_khMa1N6mpw3sT72-qmct_n6KQ0dXAX-zxDH48P74vndPX69LK4X6UFzdiQqnizgBidEVwJyYTC3EgqBBM5B0uyrOBQ2qLEhipLlXOKyLworCWUWEtn6Ga3t_fd1-jCoJsqFK6uTeu6MWisMEglpaARvf6HrrvRt_G7SBHGARMsIsV3VOG7ELwrde-rxvgfjUH_adYHzXqrWQPXUXOcu9pvH_Mm9g5TB6_0FxB2eXs</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Igrutinovic, Zoran</creator><creator>Medovic, Rasa</creator><creator>Markovic, Slavica</creator><creator>Kostic, Gordana</creator><creator>Raskovic, Zorica</creator><creator>Tanaskovic-Nestorovic, Jelena</creator><creator>Radovanovic, Marija</creator><creator>Vuletic, Biljana</creator><general>Hacettepe University Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Rosai-Dorfman disease of vertebra: Case report and literature review</title><author>Igrutinovic, Zoran ; Medovic, Rasa ; Markovic, Slavica ; Kostic, Gordana ; Raskovic, Zorica ; Tanaskovic-Nestorovic, Jelena ; Radovanovic, Marija ; Vuletic, Biljana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-9211c0921ea6596746915a736646b50d288c50fdcf1a39d39ee927bccdd232dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Back pain</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Case reports</topic><topic>Diagnosis, Differential</topic><topic>Family medical history</topic><topic>Female</topic><topic>Histiocytosis, Sinus - diagnosis</topic><topic>Histiocytosis, Sinus - surgery</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Laboratories</topic><topic>Laminectomy</topic><topic>Literature reviews</topic><topic>Sinuses</topic><topic>Spinal cord</topic><topic>Thoracic Vertebrae - pathology</topic><topic>Thoracic Vertebrae - surgery</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Igrutinovic, Zoran</creatorcontrib><creatorcontrib>Medovic, Rasa</creatorcontrib><creatorcontrib>Markovic, Slavica</creatorcontrib><creatorcontrib>Kostic, Gordana</creatorcontrib><creatorcontrib>Raskovic, Zorica</creatorcontrib><creatorcontrib>Tanaskovic-Nestorovic, Jelena</creatorcontrib><creatorcontrib>Radovanovic, Marija</creatorcontrib><creatorcontrib>Vuletic, Biljana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Igrutinovic, Zoran</au><au>Medovic, Rasa</au><au>Markovic, Slavica</au><au>Kostic, Gordana</au><au>Raskovic, Zorica</au><au>Tanaskovic-Nestorovic, Jelena</au><au>Radovanovic, Marija</au><au>Vuletic, Biljana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rosai-Dorfman disease of vertebra: Case report and literature review</atitle><jtitle>Turkish journal of pediatrics</jtitle><addtitle>Turk J Pediatr</addtitle><date>2016</date><risdate>2016</risdate><volume>58</volume><issue>5</issue><spage>566</spage><epage>571</epage><pages>566-571</pages><issn>0041-4301</issn><eissn>2791-6421</eissn><abstract>Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without lymphadenopathy. Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thoracic spine, with vertebral body fracture. A 14-year-old girl presented with cervical back pain for about one month as the only symptom. There was no lymphadenopathy. Results of laboratory tests were within reference ranges. The radiological examinations revealed collapse, osteolytic lesion and compressive fracture, which reduced vertical diameter of C4 vertebral body. The patient made a complete recovery after a limited C4 laminectomy, spondylodesis C3/C5 vertebra and biopsy of the lesion. Histologically, nonspecific cellular milieu and atypical histiocytic proliferation with emperipolesis, with CD68 and S100 positivity, confirmed a diagnosis of Rosai-Dorfman disease. Isolated extranodal skeletal Rosai-Dorfman disease should be considered among the differential diagnoses of similar changes, such as Langerhans cell histiocytosis, Erdheim-Cheister disease, eosinophilic granuloma, osteomyelitis, metastasis and lymphoma.</abstract><cop>Turkey</cop><pub>Hacettepe University Faculty of Medicine</pub><pmid>28621104</pmid><doi>10.24953/turkjped.2016.05.020</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Back pain Biopsy Bone marrow Case reports Diagnosis, Differential Family medical history Female Histiocytosis, Sinus - diagnosis Histiocytosis, Sinus - surgery Humans Immunoglobulins Laboratories Laminectomy Literature reviews Sinuses Spinal cord Thoracic Vertebrae - pathology Thoracic Vertebrae - surgery Vertebrae |
| title | Rosai-Dorfman disease of vertebra: Case report and literature review |
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