The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases
It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well‐being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemi...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2017-06, Vol.1398 (1), p.62-71 |
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| creator | Giampieri, Francesca Forbes‐Hernandez, Tamara Y. Gasparrini, Massimiliano Afrin, Sadia Cianciosi, Danila Reboredo‐Rodriguez, Patricia Varela‐Lopez, Alfonso Quiles, Jose L. Mezzetti, Bruno Battino, Maurizio |
| description | It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well‐being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti‐inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer. |
| doi_str_mv | 10.1111/nyas.13373 |
| format | Article |
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The consumption of strawberries, in particular, has been related to the maintenance of well‐being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti‐inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/nyas.13373</identifier><identifier>PMID: 28618011</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - therapeutic use ; Bioactive compounds ; Biocompatibility ; Biological effects ; Cancer ; Cardiovascular diseases ; Cardiovascular Diseases - diet therapy ; Chronic Disease - drug therapy ; Chronic illnesses ; Fragaria - chemistry ; Fragaria ananassa ; Fruit - chemistry ; Fruits ; Humans ; Inflammation ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - diet therapy ; Metabolism ; Molecular modelling ; Neoplasms - diet therapy ; Phenolic compounds ; Phenols ; Phenols - chemistry ; Phenols - therapeutic use ; Strawberries ; strawberry phenolic compounds ; Well being</subject><ispartof>Annals of the New York Academy of Sciences, 2017-06, Vol.1398 (1), p.62-71</ispartof><rights>2017 New York Academy of Sciences.</rights><rights>2017 The New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3573-2ef91f51f3e06bf9e87e8934ce9851451255dc55fd43c231a9c03629996dd1ea3</citedby><cites>FETCH-LOGICAL-c3573-2ef91f51f3e06bf9e87e8934ce9851451255dc55fd43c231a9c03629996dd1ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnyas.13373$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnyas.13373$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28618011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giampieri, Francesca</creatorcontrib><creatorcontrib>Forbes‐Hernandez, Tamara Y.</creatorcontrib><creatorcontrib>Gasparrini, Massimiliano</creatorcontrib><creatorcontrib>Afrin, Sadia</creatorcontrib><creatorcontrib>Cianciosi, Danila</creatorcontrib><creatorcontrib>Reboredo‐Rodriguez, Patricia</creatorcontrib><creatorcontrib>Varela‐Lopez, Alfonso</creatorcontrib><creatorcontrib>Quiles, Jose L.</creatorcontrib><creatorcontrib>Mezzetti, Bruno</creatorcontrib><creatorcontrib>Battino, Maurizio</creatorcontrib><title>The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. 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The consumption of strawberries, in particular, has been related to the maintenance of well‐being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti‐inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. 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| subjects | Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Antioxidants Antioxidants - chemistry Antioxidants - therapeutic use Bioactive compounds Biocompatibility Biological effects Cancer Cardiovascular diseases Cardiovascular Diseases - diet therapy Chronic Disease - drug therapy Chronic illnesses Fragaria - chemistry Fragaria ananassa Fruit - chemistry Fruits Humans Inflammation Metabolic disorders Metabolic syndrome Metabolic Syndrome - diet therapy Metabolism Molecular modelling Neoplasms - diet therapy Phenolic compounds Phenols Phenols - chemistry Phenols - therapeutic use Strawberries strawberry phenolic compounds Well being |
| title | The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases |
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