Prevalence and genetic features of rabbit hepatitis E virus in Korea
Hepatitis caused by hepatitis E virus (HEV) is a public health concern worldwide. HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation of HEV from rabbits was reported. Here, the partial capsid gene (320 bp) of HEV was detected in rabbit...
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| Veröffentlicht in: | Journal of medical virology 2017-11, Vol.89 (11), p.1995-2002 |
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| creator | Ahn, Hee‐Seop Park, Byung‐Joo Han, Sang‐Hoon Kim, Yong‐Hyun Kim, Dong‐Hwi Kim, Bo‐Sook Lee, Joong‐Bok Park, Seung‐Yong Song, Chang‐Seon Lee, Sang‐Won Choi, In‐Soo |
| description | Hepatitis caused by hepatitis E virus (HEV) is a public health concern worldwide. HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation of HEV from rabbits was reported. Here, the partial capsid gene (320 bp) of HEV was detected in rabbit feces via reverse transcriptase‐polymerase chain reaction (RT‐PCR). Rabbit HEV was found in two of six rabbit farms and 17 of 264 rabbit fecal samples (6.4%). A phylogenetic analysis of the partial capsid gene classified the 17 HEV isolates into the putative rabbit HEV clade. A full genomic sequence, KOR‐Rb‐1, was obtained from one rabbit HEV isolate by 5′ and 3′ rapid amplification of cDNA ends‐PCR and RT‐PCR, and comprised 7275 bp excluding the 3′ poly(A) tail. It shared 77.5‐86.8%, 86.6%, and 80.2‐84.3% nucleotide identities with rabbit HEV isolates from China, the US, and France, respectively. It also shared 72.3‐73.0%, 71.4%, 76.7‐78.3%, 72.8‐73.3%, and 47.1‐47.2% nucleotide identities with representative strains of HEV‐1, HEV‐2, HEV‐3, HEV‐4, and avian HEV, respectively. A full‐genome phylogenetic analysis classified KOR‐Rb‐1 into the provisional rabbit HEV clade. This isolate could be used to study the pathogenesis and zoonotic potential of rabbit HEV. |
| doi_str_mv | 10.1002/jmv.24875 |
| format | Article |
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HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation of HEV from rabbits was reported. Here, the partial capsid gene (320 bp) of HEV was detected in rabbit feces via reverse transcriptase‐polymerase chain reaction (RT‐PCR). Rabbit HEV was found in two of six rabbit farms and 17 of 264 rabbit fecal samples (6.4%). A phylogenetic analysis of the partial capsid gene classified the 17 HEV isolates into the putative rabbit HEV clade. A full genomic sequence, KOR‐Rb‐1, was obtained from one rabbit HEV isolate by 5′ and 3′ rapid amplification of cDNA ends‐PCR and RT‐PCR, and comprised 7275 bp excluding the 3′ poly(A) tail. It shared 77.5‐86.8%, 86.6%, and 80.2‐84.3% nucleotide identities with rabbit HEV isolates from China, the US, and France, respectively. It also shared 72.3‐73.0%, 71.4%, 76.7‐78.3%, 72.8‐73.3%, and 47.1‐47.2% nucleotide identities with representative strains of HEV‐1, HEV‐2, HEV‐3, HEV‐4, and avian HEV, respectively. A full‐genome phylogenetic analysis classified KOR‐Rb‐1 into the provisional rabbit HEV clade. This isolate could be used to study the pathogenesis and zoonotic potential of rabbit HEV.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24875</identifier><identifier>PMID: 28617964</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animal species ; Animals ; capsid gene ; Capsid Proteins - genetics ; China - epidemiology ; Complementary DNA ; Farms ; Feces - virology ; France - epidemiology ; genome ; Genome, Viral ; Genomes ; Genotype ; Hepatitis ; Hepatitis E - epidemiology ; Hepatitis E - transmission ; Hepatitis E - veterinary ; Hepatitis E - virology ; Hepatitis E virus - classification ; Hepatitis E virus - genetics ; Hepatitis E virus - isolation & purification ; HEV ; Humans ; Pathogenesis ; Phylogenetics ; Phylogeny ; Polyadenine ; Polyadenylation ; Polymerase chain reaction ; Prevalence ; Public health ; rabbit ; Rabbits ; Rabbits - virology ; Real-Time Polymerase Chain Reaction ; Republic of Korea - epidemiology ; RNA, Viral ; RNA-directed DNA polymerase ; Sequence Analysis, DNA ; Strains (organisms) ; United States - epidemiology ; Virology ; Viruses ; Zoonoses ; zoonosis</subject><ispartof>Journal of medical virology, 2017-11, Vol.89 (11), p.1995-2002</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-bf53b1c69cd72004df037a5ca19b6875e34fb558ea84f376dba920ac9906d1593</citedby><cites>FETCH-LOGICAL-c3535-bf53b1c69cd72004df037a5ca19b6875e34fb558ea84f376dba920ac9906d1593</cites><orcidid>0000-0001-7266-6571</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24875$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24875$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28617964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Hee‐Seop</creatorcontrib><creatorcontrib>Park, Byung‐Joo</creatorcontrib><creatorcontrib>Han, Sang‐Hoon</creatorcontrib><creatorcontrib>Kim, Yong‐Hyun</creatorcontrib><creatorcontrib>Kim, Dong‐Hwi</creatorcontrib><creatorcontrib>Kim, Bo‐Sook</creatorcontrib><creatorcontrib>Lee, Joong‐Bok</creatorcontrib><creatorcontrib>Park, Seung‐Yong</creatorcontrib><creatorcontrib>Song, Chang‐Seon</creatorcontrib><creatorcontrib>Lee, Sang‐Won</creatorcontrib><creatorcontrib>Choi, In‐Soo</creatorcontrib><title>Prevalence and genetic features of rabbit hepatitis E virus in Korea</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Hepatitis caused by hepatitis E virus (HEV) is a public health concern worldwide. HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation of HEV from rabbits was reported. Here, the partial capsid gene (320 bp) of HEV was detected in rabbit feces via reverse transcriptase‐polymerase chain reaction (RT‐PCR). Rabbit HEV was found in two of six rabbit farms and 17 of 264 rabbit fecal samples (6.4%). A phylogenetic analysis of the partial capsid gene classified the 17 HEV isolates into the putative rabbit HEV clade. A full genomic sequence, KOR‐Rb‐1, was obtained from one rabbit HEV isolate by 5′ and 3′ rapid amplification of cDNA ends‐PCR and RT‐PCR, and comprised 7275 bp excluding the 3′ poly(A) tail. It shared 77.5‐86.8%, 86.6%, and 80.2‐84.3% nucleotide identities with rabbit HEV isolates from China, the US, and France, respectively. It also shared 72.3‐73.0%, 71.4%, 76.7‐78.3%, 72.8‐73.3%, and 47.1‐47.2% nucleotide identities with representative strains of HEV‐1, HEV‐2, HEV‐3, HEV‐4, and avian HEV, respectively. A full‐genome phylogenetic analysis classified KOR‐Rb‐1 into the provisional rabbit HEV clade. This isolate could be used to study the pathogenesis and zoonotic potential of rabbit HEV.</description><subject>Animal species</subject><subject>Animals</subject><subject>capsid gene</subject><subject>Capsid Proteins - genetics</subject><subject>China - epidemiology</subject><subject>Complementary DNA</subject><subject>Farms</subject><subject>Feces - virology</subject><subject>France - epidemiology</subject><subject>genome</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Hepatitis</subject><subject>Hepatitis E - epidemiology</subject><subject>Hepatitis E - transmission</subject><subject>Hepatitis E - veterinary</subject><subject>Hepatitis E - virology</subject><subject>Hepatitis E virus - classification</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - isolation & purification</subject><subject>HEV</subject><subject>Humans</subject><subject>Pathogenesis</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Polyadenine</subject><subject>Polyadenylation</subject><subject>Polymerase chain reaction</subject><subject>Prevalence</subject><subject>Public health</subject><subject>rabbit</subject><subject>Rabbits</subject><subject>Rabbits - virology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Republic of Korea - epidemiology</subject><subject>RNA, Viral</subject><subject>RNA-directed DNA polymerase</subject><subject>Sequence Analysis, DNA</subject><subject>Strains (organisms)</subject><subject>United States - epidemiology</subject><subject>Virology</subject><subject>Viruses</subject><subject>Zoonoses</subject><subject>zoonosis</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10DtPwzAUhmELgWi5DPwBZIkFhrR2HNvxiEq5FsEArJHtnICrNCl2UtR_TyCFAYnpLI8-Hb0IHVEyooTE4_liNYqTVPItNKREiUgRSbfRkNBEREJQPkB7IcwJIamK4100iFNBpRLJEF08eljpEioLWFc5foUKGmdxAbppPQRcF9hrY1yD32CpG9e4gKd45XwbsKvwXe1BH6CdQpcBDjd3Hz1fTp8m19Hs4epmcj6LLOOMR6bgzFArlM1lTEiSF4RJza2myojue2BJYThPQadJwaTIjVYx0VYpInLKFdtHp_3u0tfvLYQmW7hgoSx1BXUbMqookSphinb05A-d162vuu86xZRMUyrjTp31yvo6BA9FtvRuof06oyT7Spt1abPvtJ093iy2ZgH5r_xp2YFxDz5cCev_l7Lb-5d-8hPYB4EU</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Ahn, Hee‐Seop</creator><creator>Park, Byung‐Joo</creator><creator>Han, Sang‐Hoon</creator><creator>Kim, Yong‐Hyun</creator><creator>Kim, Dong‐Hwi</creator><creator>Kim, Bo‐Sook</creator><creator>Lee, Joong‐Bok</creator><creator>Park, Seung‐Yong</creator><creator>Song, Chang‐Seon</creator><creator>Lee, Sang‐Won</creator><creator>Choi, In‐Soo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7266-6571</orcidid></search><sort><creationdate>201711</creationdate><title>Prevalence and genetic features of rabbit hepatitis E virus in Korea</title><author>Ahn, Hee‐Seop ; Park, Byung‐Joo ; Han, Sang‐Hoon ; Kim, Yong‐Hyun ; Kim, Dong‐Hwi ; Kim, Bo‐Sook ; Lee, Joong‐Bok ; Park, Seung‐Yong ; Song, Chang‐Seon ; Lee, Sang‐Won ; Choi, In‐Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-bf53b1c69cd72004df037a5ca19b6875e34fb558ea84f376dba920ac9906d1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal species</topic><topic>Animals</topic><topic>capsid gene</topic><topic>Capsid Proteins - genetics</topic><topic>China - epidemiology</topic><topic>Complementary DNA</topic><topic>Farms</topic><topic>Feces - virology</topic><topic>France - epidemiology</topic><topic>genome</topic><topic>Genome, Viral</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Hepatitis</topic><topic>Hepatitis E - epidemiology</topic><topic>Hepatitis E - transmission</topic><topic>Hepatitis E - veterinary</topic><topic>Hepatitis E - virology</topic><topic>Hepatitis E virus - classification</topic><topic>Hepatitis E virus - genetics</topic><topic>Hepatitis E virus - isolation & purification</topic><topic>HEV</topic><topic>Humans</topic><topic>Pathogenesis</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Polyadenine</topic><topic>Polyadenylation</topic><topic>Polymerase chain reaction</topic><topic>Prevalence</topic><topic>Public health</topic><topic>rabbit</topic><topic>Rabbits</topic><topic>Rabbits - virology</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Republic of Korea - epidemiology</topic><topic>RNA, Viral</topic><topic>RNA-directed DNA polymerase</topic><topic>Sequence Analysis, DNA</topic><topic>Strains (organisms)</topic><topic>United States - epidemiology</topic><topic>Virology</topic><topic>Viruses</topic><topic>Zoonoses</topic><topic>zoonosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Hee‐Seop</creatorcontrib><creatorcontrib>Park, Byung‐Joo</creatorcontrib><creatorcontrib>Han, Sang‐Hoon</creatorcontrib><creatorcontrib>Kim, Yong‐Hyun</creatorcontrib><creatorcontrib>Kim, Dong‐Hwi</creatorcontrib><creatorcontrib>Kim, Bo‐Sook</creatorcontrib><creatorcontrib>Lee, Joong‐Bok</creatorcontrib><creatorcontrib>Park, Seung‐Yong</creatorcontrib><creatorcontrib>Song, Chang‐Seon</creatorcontrib><creatorcontrib>Lee, Sang‐Won</creatorcontrib><creatorcontrib>Choi, In‐Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Hee‐Seop</au><au>Park, Byung‐Joo</au><au>Han, Sang‐Hoon</au><au>Kim, Yong‐Hyun</au><au>Kim, Dong‐Hwi</au><au>Kim, Bo‐Sook</au><au>Lee, Joong‐Bok</au><au>Park, Seung‐Yong</au><au>Song, Chang‐Seon</au><au>Lee, Sang‐Won</au><au>Choi, In‐Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and genetic features of rabbit hepatitis E virus in Korea</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2017-11</date><risdate>2017</risdate><volume>89</volume><issue>11</issue><spage>1995</spage><epage>2002</epage><pages>1995-2002</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Hepatitis caused by hepatitis E virus (HEV) is a public health concern worldwide. HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation of HEV from rabbits was reported. Here, the partial capsid gene (320 bp) of HEV was detected in rabbit feces via reverse transcriptase‐polymerase chain reaction (RT‐PCR). Rabbit HEV was found in two of six rabbit farms and 17 of 264 rabbit fecal samples (6.4%). A phylogenetic analysis of the partial capsid gene classified the 17 HEV isolates into the putative rabbit HEV clade. A full genomic sequence, KOR‐Rb‐1, was obtained from one rabbit HEV isolate by 5′ and 3′ rapid amplification of cDNA ends‐PCR and RT‐PCR, and comprised 7275 bp excluding the 3′ poly(A) tail. It shared 77.5‐86.8%, 86.6%, and 80.2‐84.3% nucleotide identities with rabbit HEV isolates from China, the US, and France, respectively. It also shared 72.3‐73.0%, 71.4%, 76.7‐78.3%, 72.8‐73.3%, and 47.1‐47.2% nucleotide identities with representative strains of HEV‐1, HEV‐2, HEV‐3, HEV‐4, and avian HEV, respectively. A full‐genome phylogenetic analysis classified KOR‐Rb‐1 into the provisional rabbit HEV clade. This isolate could be used to study the pathogenesis and zoonotic potential of rabbit HEV.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28617964</pmid><doi>10.1002/jmv.24875</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7266-6571</orcidid></addata></record> |
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| subjects | Animal species Animals capsid gene Capsid Proteins - genetics China - epidemiology Complementary DNA Farms Feces - virology France - epidemiology genome Genome, Viral Genomes Genotype Hepatitis Hepatitis E - epidemiology Hepatitis E - transmission Hepatitis E - veterinary Hepatitis E - virology Hepatitis E virus - classification Hepatitis E virus - genetics Hepatitis E virus - isolation & purification HEV Humans Pathogenesis Phylogenetics Phylogeny Polyadenine Polyadenylation Polymerase chain reaction Prevalence Public health rabbit Rabbits Rabbits - virology Real-Time Polymerase Chain Reaction Republic of Korea - epidemiology RNA, Viral RNA-directed DNA polymerase Sequence Analysis, DNA Strains (organisms) United States - epidemiology Virology Viruses Zoonoses zoonosis |
| title | Prevalence and genetic features of rabbit hepatitis E virus in Korea |
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