Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7

The channel-kinase TRPM7 is important for the survival, proliferation, and differentiation, of many cell types. Both plasma membrane channel activity and kinase function are implicated in these roles. Channel activity is greater in less differentiated hepatoma cells compared with non-dividing, termi...

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Veröffentlicht in:	Differentiation (London) 2017-07, Vol.96, p.15-25
Hauptverfasser:	Ogunrinde, Adenike, Pereira, Robyn D., Beaton, Natalie, Lam, D. Hung, Whetstone, Christiane, Hill, Ceredwyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Benzimidazoles - pharmacology C-Terminus Cell Differentiation Cell growth Cell Nucleolus - metabolism Channel gating Cytoplasm Dexamethasone Enzymes Fluorescence HEK293 Cells Hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Hepatoma Humans Immunofluorescence Kinases Labeling Liver Localization Lymphocytes B Male Mice Nuclear envelope Nuclear Envelope - metabolism Nuclei Nucleoli Nucleolus Nucleus Oncostatin M Patch clamp Protein Kinase Inhibitors - pharmacology Pyridones - pharmacology Rats Rats, Sprague-Dawley Transient receptor potential proteins TRPM Cation Channels - genetics TRPM Cation Channels - metabolism α-Kinase
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