Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor

Abstract Sphingosine 1-phosphate (S1P) is as an extracellular factor that acts as a potent lipid mediator by binding to specific receptors, S1P receptors (S1PRs). However, the precise role of S1P in human platelets that express S1PRs has not yet been fully clarified. We previously reported that heat...

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Veröffentlicht in:	Thrombosis research 2017-08, Vol.156, p.91-100
Hauptverfasser:	Onuma, Takashi, Tanabe, Kumiko, Kito, Yuko, Tsujimoto, Masanori, Uematsu, Kodai, Enomoto, Yukiko, Matsushima-Nishiwaki, Rie, Doi, Tomoaki, Nagase, Kiyoshi, Akamatsu, Shigeru, Tokuda, Haruhiko, Ogura, Shinji, Iwama, Toru, Kozawa, Osamu, Iida, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - metabolism Collagen Collagen - metabolism Hematology, Oncology and Palliative Medicine HSP27 Humans Lysophospholipids - metabolism Phosphorylation Platelet Platelet Activation - drug effects Receptor Receptors, Lysosphingolipid - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate
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