Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs
Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa tes...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2017-08, Vol.18 (4), p.641-650 |
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| creator | Seiffert, Piotr Derejczyk, Jarosław Kawa, Jacek Marcisz, Czesław Czernek, Małgorzata Szymszal, Jan Kapko, Wojciech Bugdol, Monika Torbus, Anna Stępień-Wyrobiec, Olga |
| description | Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide). Sixty-nine study subjects (58%) met criteria for frailty. Fifty-five participants in MPS group (61.1% of MPS group) and fourteen (50%) in control group. All of the patients that scored positive in walk speed criterion of frailty were frail. When all MPS patients were considered, the number of components scored positive for frailty was directly related to the walk speed (r = −0.70, p |
| doi_str_mv | 10.1007/s10522-017-9716-6 |
| format | Article |
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The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide). Sixty-nine study subjects (58%) met criteria for frailty. Fifty-five participants in MPS group (61.1% of MPS group) and fourteen (50%) in control group. All of the patients that scored positive in walk speed criterion of frailty were frail. When all MPS patients were considered, the number of components scored positive for frailty was directly related to the walk speed (r = −0.70, p < 0.0001). In MPS group LCT scores were significantly higher for frailty patients compared to non-frailty (p = 0.0027). When all MPS patients were considered, the number of components scored positive for frailty was directly related LCT score (r = 0.37, p = 0.0004). There was a relationship between LCT and walk speed (r = −0.31, p = 0.0032). Our observations provide new information about the relationship between frailty and MPS, suggest the need for increased awareness of frailty in MPS patients and conversely. Our study provides data for a discussion on pathophysiological background of the frailty syndrome (FS), emphasizing the theories of the important impact of dopaminergic system deficit and encourages further research on the role of LCT in measuring it.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-017-9716-6</identifier><identifier>PMID: 28612154</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Aging ; Basal ganglia ; Benserazide - administration & dosage ; Biomedical and Life Sciences ; Case-Control Studies ; Cell Biology ; Central nervous system diseases ; Cross-Sectional Studies ; Developmental Biology ; Dopamine - metabolism ; Dopamine Agents - administration & dosage ; Dopamine receptors ; Drug Combinations ; Female ; Frail Elderly ; Frailty ; Frailty - diagnosis ; Frailty - epidemiology ; Frailty - metabolism ; Frailty - physiopathology ; Geriatric Assessment - methods ; Geriatrics ; Geriatrics/Gerontology ; Humans ; Inpatients ; Levodopa ; Levodopa - administration & dosage ; Life Sciences ; Male ; Movement disorders ; Parkinson Disease - diagnosis ; Parkinson Disease - epidemiology ; Parkinson Disease - metabolism ; Parkinson Disease - physiopathology ; Phenotype ; Poland - epidemiology ; Predictive Value of Tests ; Prevalence ; Research Article ; Severity of Illness Index</subject><ispartof>Biogerontology (Dordrecht), 2017-08, Vol.18 (4), p.641-650</ispartof><rights>Springer Science+Business Media B.V. 2017</rights><rights>Biogerontology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2dba4caa1a8bd8ff35a62593a850ebaf40c58af9beb8521d8314b8cfe2ec2c103</citedby><cites>FETCH-LOGICAL-c372t-2dba4caa1a8bd8ff35a62593a850ebaf40c58af9beb8521d8314b8cfe2ec2c103</cites><orcidid>0000-0001-7987-5640</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-017-9716-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-017-9716-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28612154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seiffert, Piotr</creatorcontrib><creatorcontrib>Derejczyk, Jarosław</creatorcontrib><creatorcontrib>Kawa, Jacek</creatorcontrib><creatorcontrib>Marcisz, Czesław</creatorcontrib><creatorcontrib>Czernek, Małgorzata</creatorcontrib><creatorcontrib>Szymszal, Jan</creatorcontrib><creatorcontrib>Kapko, Wojciech</creatorcontrib><creatorcontrib>Bugdol, Monika</creatorcontrib><creatorcontrib>Torbus, Anna</creatorcontrib><creatorcontrib>Stępień-Wyrobiec, Olga</creatorcontrib><title>Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide). Sixty-nine study subjects (58%) met criteria for frailty. Fifty-five participants in MPS group (61.1% of MPS group) and fourteen (50%) in control group. All of the patients that scored positive in walk speed criterion of frailty were frail. When all MPS patients were considered, the number of components scored positive for frailty was directly related to the walk speed (r = −0.70, p < 0.0001). In MPS group LCT scores were significantly higher for frailty patients compared to non-frailty (p = 0.0027). When all MPS patients were considered, the number of components scored positive for frailty was directly related LCT score (r = 0.37, p = 0.0004). There was a relationship between LCT and walk speed (r = −0.31, p = 0.0032). Our observations provide new information about the relationship between frailty and MPS, suggest the need for increased awareness of frailty in MPS patients and conversely. Our study provides data for a discussion on pathophysiological background of the frailty syndrome (FS), emphasizing the theories of the important impact of dopaminergic system deficit and encourages further research on the role of LCT in measuring it.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Basal ganglia</subject><subject>Benserazide - administration & dosage</subject><subject>Biomedical and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Central nervous system diseases</subject><subject>Cross-Sectional Studies</subject><subject>Developmental Biology</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Agents - administration & dosage</subject><subject>Dopamine receptors</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Frailty - diagnosis</subject><subject>Frailty - 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epidemiology</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - physiopathology</topic><topic>Phenotype</topic><topic>Poland - epidemiology</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Research Article</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seiffert, Piotr</creatorcontrib><creatorcontrib>Derejczyk, Jarosław</creatorcontrib><creatorcontrib>Kawa, Jacek</creatorcontrib><creatorcontrib>Marcisz, Czesław</creatorcontrib><creatorcontrib>Czernek, Małgorzata</creatorcontrib><creatorcontrib>Szymszal, Jan</creatorcontrib><creatorcontrib>Kapko, Wojciech</creatorcontrib><creatorcontrib>Bugdol, Monika</creatorcontrib><creatorcontrib>Torbus, Anna</creatorcontrib><creatorcontrib>Stępień-Wyrobiec, Olga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seiffert, Piotr</au><au>Derejczyk, Jarosław</au><au>Kawa, Jacek</au><au>Marcisz, Czesław</au><au>Czernek, Małgorzata</au><au>Szymszal, Jan</au><au>Kapko, Wojciech</au><au>Bugdol, Monika</au><au>Torbus, Anna</au><au>Stępień-Wyrobiec, Olga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>18</volume><issue>4</issue><spage>641</spage><epage>650</epage><pages>641-650</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide). Sixty-nine study subjects (58%) met criteria for frailty. Fifty-five participants in MPS group (61.1% of MPS group) and fourteen (50%) in control group. All of the patients that scored positive in walk speed criterion of frailty were frail. When all MPS patients were considered, the number of components scored positive for frailty was directly related to the walk speed (r = −0.70, p < 0.0001). In MPS group LCT scores were significantly higher for frailty patients compared to non-frailty (p = 0.0027). When all MPS patients were considered, the number of components scored positive for frailty was directly related LCT score (r = 0.37, p = 0.0004). There was a relationship between LCT and walk speed (r = −0.31, p = 0.0032). Our observations provide new information about the relationship between frailty and MPS, suggest the need for increased awareness of frailty in MPS patients and conversely. Our study provides data for a discussion on pathophysiological background of the frailty syndrome (FS), emphasizing the theories of the important impact of dopaminergic system deficit and encourages further research on the role of LCT in measuring it.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28612154</pmid><doi>10.1007/s10522-017-9716-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7987-5640</orcidid></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Aging Basal ganglia Benserazide - administration & dosage Biomedical and Life Sciences Case-Control Studies Cell Biology Central nervous system diseases Cross-Sectional Studies Developmental Biology Dopamine - metabolism Dopamine Agents - administration & dosage Dopamine receptors Drug Combinations Female Frail Elderly Frailty Frailty - diagnosis Frailty - epidemiology Frailty - metabolism Frailty - physiopathology Geriatric Assessment - methods Geriatrics Geriatrics/Gerontology Humans Inpatients Levodopa Levodopa - administration & dosage Life Sciences Male Movement disorders Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson Disease - metabolism Parkinson Disease - physiopathology Phenotype Poland - epidemiology Predictive Value of Tests Prevalence Research Article Severity of Illness Index |
| title | Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs |
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