Polydopamine mediated assembly of hydroxyapatite nanoparticles and bone morphogenetic protein‐2 on magnesium alloys for enhanced corrosion resistance and bone regeneration

Magnesium alloys have the great potential to be used as orthopedic implants due to their biodegradability and mechanical resemblance to human cortical bone. However, the rapid degradation in physiological environment with the evolution of hydrogen gas release hinders their clinical applications. In...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2017-10, Vol.105 (10), p.2750-2761
Hauptverfasser:	Jiang, Yanan, Wang, Bi, Jia, Zhanrong, Lu, Xiong, Fang, Liming, Wang, Kefeng, Ren, Fuzeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion tests Adhesive bonding Alloys Alloys - chemistry Animals Assembly Biocompatibility Biodegradability Biodegradation Biomedical materials Bonding strength Bone growth Bone implants Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - pharmacology bone regeneration Bone Regeneration - drug effects Cell adhesion Cell culture Coated Materials, Biocompatible - chemistry Coating effects Corrosion Corrosion potential Corrosion rate Corrosion resistance Corrosion resistant alloys Corrosion tests Cortical bone Degradation Durapatite - chemistry Electrochemical corrosion Electrochemistry Hydrogen evolution Hydroxyapatite hydroxyapatite nanoparticles Immobilization Implantation In vivo methods and tests Indoles - chemistry Inflammation Magnesium Magnesium - chemistry magnesium alloys Magnesium base alloys Mesenchymal Stromal Cells - cytology Nanoparticles Nanoparticles - chemistry Osteogenesis polydopamine Polymers - chemistry Protective coatings Rabbits Rats, Sprague-Dawley Regeneration Surface Properties Surgical implants Synergistic effect Therapeutic applications Wettability
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