Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure
Problem The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cy...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2017-11, Vol.78 (5), p.n/a |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Kitaya, Kotaro Matsubayashi, Hidehiko Takaya, Yukiko Nishiyama, Rie Yamaguchi, Kohei Takeuchi, Takumi Ishikawa, Tomomoto |
| description | Problem
The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles.
Method of study
Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied.
Results
33.7% of infertile women with RIF were diagnosed with CE. Following the first‐line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second‐line metronidazole/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle (P=.031, RR 1.48, 95% CI 1.03‐2.12) and cumulative three ET cycles (P=.037, RR 1.39, 95% CI 1.02‐1.90) following antibiotic treatment in the cured RIF/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF/non‐CE group (22.1% and 27.9%, respectively).
Conclusion
Chronic endometritis was found in one‐third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF. |
| doi_str_mv | 10.1111/aji.12719 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1909233624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1909233624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-7e44f0f5624469a4d0223885bd22e59646c1525c127a404c641469709d22745d3</originalsourceid><addsrcrecordid>eNp1kU1P3DAQhq2KqlDaA3-gssQFDoGx43z4iFChVCtxac-RN5nArBJ7aztdce0v78DSHirVsmRr_PjR2K8QJwouFI9Lt6ELpRtl34gjVQMU0NrmgPdg6qIx0B6K9yltALheNu_EoW5raCtbH4lfK_qJck0xP8roMsoxTFPYkX-QIbpJOp9pTSFTL3NEl2f0mZko-8cYPFfRD2HGHClTkuR5jhgzTSh3XPdyR89m3PJdHCTN24mVLlPwcnQ0LRE_iLejmxJ-fF2Pxfebz9-uvxSr-9u766tV0ZdVaYsGjRlhrGptTG2dGUDrsm2r9aA18ltM3atKVz1_hDNg-too5hqwfN6YaiiPxdneu43hx4IpdzOlHiduCMOSOmXB6rJkP6On_6CbsETP3TFVKQBtDTB1vqf6GFKKOHbbSLOLT52C7jmYjoPpXoJh9tOrcVnPOPwl_yTBwOUe2PHfPf3f1F19vdsrfwOiE5ei</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1951002940</pqid></control><display><type>article</type><title>Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kitaya, Kotaro ; Matsubayashi, Hidehiko ; Takaya, Yukiko ; Nishiyama, Rie ; Yamaguchi, Kohei ; Takeuchi, Takumi ; Ishikawa, Tomomoto</creator><creatorcontrib>Kitaya, Kotaro ; Matsubayashi, Hidehiko ; Takaya, Yukiko ; Nishiyama, Rie ; Yamaguchi, Kohei ; Takeuchi, Takumi ; Ishikawa, Tomomoto</creatorcontrib><description>Problem
The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles.
Method of study
Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied.
Results
33.7% of infertile women with RIF were diagnosed with CE. Following the first‐line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second‐line metronidazole/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle (P=.031, RR 1.48, 95% CI 1.03‐2.12) and cumulative three ET cycles (P=.037, RR 1.39, 95% CI 1.02‐1.90) following antibiotic treatment in the cured RIF/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF/non‐CE group (22.1% and 27.9%, respectively).
Conclusion
Chronic endometritis was found in one‐third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12719</identifier><identifier>PMID: 28608596</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Administration, Oral ; Adult ; Antibiotics ; Biopsy ; Birth Rate ; Chronic Disease ; chronic endometritis ; Ciprofloxacin ; Ciprofloxacin - therapeutic use ; Doxycycline ; Embryo transfer ; Endometritis ; Endometritis - drug therapy ; Endometritis - epidemiology ; Endometrium ; Female ; Fertility ; Health risk assessment ; Humans ; Infertility, Female - drug therapy ; Infertility, Female - epidemiology ; Japan - epidemiology ; Live Birth - epidemiology ; live birth rate ; Metronidazole ; Metronidazole - therapeutic use ; oral antibiotic treatment ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; prospective study ; repeated implantation failure</subject><ispartof>American journal of reproductive immunology (1989), 2017-11, Vol.78 (5), p.n/a</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-7e44f0f5624469a4d0223885bd22e59646c1525c127a404c641469709d22745d3</citedby><cites>FETCH-LOGICAL-c3539-7e44f0f5624469a4d0223885bd22e59646c1525c127a404c641469709d22745d3</cites><orcidid>0000-0002-5693-3139</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12719$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12719$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28608596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitaya, Kotaro</creatorcontrib><creatorcontrib>Matsubayashi, Hidehiko</creatorcontrib><creatorcontrib>Takaya, Yukiko</creatorcontrib><creatorcontrib>Nishiyama, Rie</creatorcontrib><creatorcontrib>Yamaguchi, Kohei</creatorcontrib><creatorcontrib>Takeuchi, Takumi</creatorcontrib><creatorcontrib>Ishikawa, Tomomoto</creatorcontrib><title>Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles.
Method of study
Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied.
Results
33.7% of infertile women with RIF were diagnosed with CE. Following the first‐line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second‐line metronidazole/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle (P=.031, RR 1.48, 95% CI 1.03‐2.12) and cumulative three ET cycles (P=.037, RR 1.39, 95% CI 1.02‐1.90) following antibiotic treatment in the cured RIF/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF/non‐CE group (22.1% and 27.9%, respectively).
Conclusion
Chronic endometritis was found in one‐third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Antibiotics</subject><subject>Biopsy</subject><subject>Birth Rate</subject><subject>Chronic Disease</subject><subject>chronic endometritis</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Doxycycline</subject><subject>Embryo transfer</subject><subject>Endometritis</subject><subject>Endometritis - drug therapy</subject><subject>Endometritis - epidemiology</subject><subject>Endometrium</subject><subject>Female</subject><subject>Fertility</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Infertility, Female - drug therapy</subject><subject>Infertility, Female - epidemiology</subject><subject>Japan - epidemiology</subject><subject>Live Birth - epidemiology</subject><subject>live birth rate</subject><subject>Metronidazole</subject><subject>Metronidazole - therapeutic use</subject><subject>oral antibiotic treatment</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><subject>prospective study</subject><subject>repeated implantation failure</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2KqlDaA3-gssQFDoGx43z4iFChVCtxac-RN5nArBJ7aztdce0v78DSHirVsmRr_PjR2K8QJwouFI9Lt6ELpRtl34gjVQMU0NrmgPdg6qIx0B6K9yltALheNu_EoW5raCtbH4lfK_qJck0xP8roMsoxTFPYkX-QIbpJOp9pTSFTL3NEl2f0mZko-8cYPFfRD2HGHClTkuR5jhgzTSh3XPdyR89m3PJdHCTN24mVLlPwcnQ0LRE_iLejmxJ-fF2Pxfebz9-uvxSr-9u766tV0ZdVaYsGjRlhrGptTG2dGUDrsm2r9aA18ltM3atKVz1_hDNg-too5hqwfN6YaiiPxdneu43hx4IpdzOlHiduCMOSOmXB6rJkP6On_6CbsETP3TFVKQBtDTB1vqf6GFKKOHbbSLOLT52C7jmYjoPpXoJh9tOrcVnPOPwl_yTBwOUe2PHfPf3f1F19vdsrfwOiE5ei</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Kitaya, Kotaro</creator><creator>Matsubayashi, Hidehiko</creator><creator>Takaya, Yukiko</creator><creator>Nishiyama, Rie</creator><creator>Yamaguchi, Kohei</creator><creator>Takeuchi, Takumi</creator><creator>Ishikawa, Tomomoto</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5693-3139</orcidid></search><sort><creationdate>201711</creationdate><title>Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure</title><author>Kitaya, Kotaro ; Matsubayashi, Hidehiko ; Takaya, Yukiko ; Nishiyama, Rie ; Yamaguchi, Kohei ; Takeuchi, Takumi ; Ishikawa, Tomomoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-7e44f0f5624469a4d0223885bd22e59646c1525c127a404c641469709d22745d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Antibiotics</topic><topic>Biopsy</topic><topic>Birth Rate</topic><topic>Chronic Disease</topic><topic>chronic endometritis</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Doxycycline</topic><topic>Embryo transfer</topic><topic>Endometritis</topic><topic>Endometritis - drug therapy</topic><topic>Endometritis - epidemiology</topic><topic>Endometrium</topic><topic>Female</topic><topic>Fertility</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Infertility, Female - drug therapy</topic><topic>Infertility, Female - epidemiology</topic><topic>Japan - epidemiology</topic><topic>Live Birth - epidemiology</topic><topic>live birth rate</topic><topic>Metronidazole</topic><topic>Metronidazole - therapeutic use</topic><topic>oral antibiotic treatment</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><topic>prospective study</topic><topic>repeated implantation failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitaya, Kotaro</creatorcontrib><creatorcontrib>Matsubayashi, Hidehiko</creatorcontrib><creatorcontrib>Takaya, Yukiko</creatorcontrib><creatorcontrib>Nishiyama, Rie</creatorcontrib><creatorcontrib>Yamaguchi, Kohei</creatorcontrib><creatorcontrib>Takeuchi, Takumi</creatorcontrib><creatorcontrib>Ishikawa, Tomomoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitaya, Kotaro</au><au>Matsubayashi, Hidehiko</au><au>Takaya, Yukiko</au><au>Nishiyama, Rie</au><au>Yamaguchi, Kohei</au><au>Takeuchi, Takumi</au><au>Ishikawa, Tomomoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2017-11</date><risdate>2017</risdate><volume>78</volume><issue>5</issue><epage>n/a</epage><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles.
Method of study
Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical/histopathologic diagnosis of CE. Following antibiotic administration to the RIF/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied.
Results
33.7% of infertile women with RIF were diagnosed with CE. Following the first‐line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second‐line metronidazole/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle (P=.031, RR 1.48, 95% CI 1.03‐2.12) and cumulative three ET cycles (P=.037, RR 1.39, 95% CI 1.02‐1.90) following antibiotic treatment in the cured RIF/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF/non‐CE group (22.1% and 27.9%, respectively).
Conclusion
Chronic endometritis was found in one‐third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28608596</pmid><doi>10.1111/aji.12719</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5693-3139</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Administration, Oral Adult Antibiotics Biopsy Birth Rate Chronic Disease chronic endometritis Ciprofloxacin Ciprofloxacin - therapeutic use Doxycycline Embryo transfer Endometritis Endometritis - drug therapy Endometritis - epidemiology Endometrium Female Fertility Health risk assessment Humans Infertility, Female - drug therapy Infertility, Female - epidemiology Japan - epidemiology Live Birth - epidemiology live birth rate Metronidazole Metronidazole - therapeutic use oral antibiotic treatment Pregnancy Pregnancy Outcome Prospective Studies prospective study repeated implantation failure |
| title | Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure |
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