Hepatitis B virus X protein–elevated MSL2 modulates hepatitis B virus covalently closed circular DNA by inducing degradation of APOBEC3B to enhance hepatocarcinogenesis

Chronic hepatitis B virus (HBV) infection is a leading cause in the occurrence of hepatitis B, liver cirrhosis, and liver cancer, in which nuclear HBV covalently closed circular DNA (cccDNA), the genomic form that templates viral transcription and sustains viral persistence, plays crucial roles. In...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2017-11, Vol.66 (5), p.1413-1429
Hauptverfasser:	Gao, Yuen, Feng, Jinyan, Yang, Guang, Zhang, Shuqin, Liu, Yunxia, Bu, Yanan, Sun, Mingming, Zhao, Man, Chen, Fuquan, Zhang, Weiying, Ye, Lihong, Zhang, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Carcinoma, Hepatocellular - virology Chromatin Chronic infection Circular DNA Cirrhosis Cytidine Deaminase - metabolism Deoxyribonucleic acid DNA DNA microarrays DNA, Circular - metabolism HBX protein Hep G2 Cells Hepatitis Hepatitis B Hepatitis B virus - physiology Hepatocyte Nuclear Factor 3-alpha - metabolism Hepatocytes Hepatology Hepatoma Humans Immunoprecipitation Liver Liver cancer Liver cirrhosis Liver Neoplasms - virology Mice, Transgenic Minor Histocompatibility Antigens - metabolism Phosphoproteins - metabolism Reporter gene Rodents Trans-Activators - metabolism Transcription Transcription Factors Transgenic animals Transgenic mice Ubiquitin Ubiquitin-Protein Ligases - metabolism Ubiquitination Up-Regulation Viral Regulatory and Accessory Proteins Virus Replication Yes-associated protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!