Efficacy of Peptide Receptor Radionuclide Therapy for Functional Metastatic Paraganglioma and Pheochromocytoma

PurposeTreatment options for unresectable paraganglioma (PGL)/pheochromocytoma (PCC), especially with uncontrolled secondary hypertension (HTN), are limited. Preliminary studies with peptide receptor radionuclide therapy (PRRT) suggest efficacy, but data on HTN control and survival are lacking. We a...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2017-09, Vol.102 (9), p.3278-3287
Hauptverfasser:	Kong, Grace, Grozinsky-Glasberg, Simona, Hofman, Michael S, Callahan, Jason, Meirovitz, Amichay, Maimon, Ofra, Pattison, David A, Gross, David J, Hicks, Rodney J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - mortality Adrenal Gland Neoplasms - pathology Adrenal Gland Neoplasms - radiotherapy Adult Aged Biopsy, Needle Chemotherapy Cohort Studies Computed tomography Coordination Complexes - administration & dosage Disease control Disease-Free Survival Dose-Response Relationship, Radiation Female Humans Immunohistochemistry Kaplan-Meier Estimate Kidneys Lymphopenia Male Metastases Metastasis Middle Aged Neuroendocrine tumors Octreotide - administration & dosage Octreotide - analogs & derivatives Paraganglioma Paraganglioma - drug therapy Paraganglioma - mortality Paraganglioma - pathology Patients Peptides Pheochromocytoma Pheochromocytoma - mortality Pheochromocytoma - pathology Pheochromocytoma - radiotherapy Prognosis Radiation Radiation therapy Radioisotopes Radioisotopes - therapeutic use Receptors, Peptide Renal function Retrospective Studies Risk Assessment Somatostatin Somatostatin receptors Survival Survival Analysis Thrombocytopenia Toxicity Treatment Outcome Young Adult
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