A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP‑1 Receptor Agonist

We have developed a chemically controlled very long-acting delivery system to support once-monthly administration of a peptidic GLP-1R agonist. Initially, the prototypical GLP-1R agonist exenatide was covalently attached to hydrogel microspheres by a self-cleaving β-eliminative linker; after subcuta...

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Veröffentlicht in:	ACS chemical biology 2017-08, Vol.12 (8), p.2107-2116
Hauptverfasser:	Schneider, Eric L, Hearn, Brian R, Pfaff, Samuel J, Reid, Ralph, Parkes, David G, Vrang, Niels, Ashley, Gary W, Santi, Daniel V
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetes Mellitus, Type 2 - drug therapy Drug Delivery Systems Glucagon-Like Peptide-1 Receptor - agonists Humans Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacokinetics Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacokinetics Microspheres Molecular Structure Time Factors
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