Does the ileal brake mechanism contribute to sustained weight loss after bariatric surgery?
Bariatric surgery is currently the most effective strategy for treating morbid obesity. Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow‐up. This review revisits a well‐established physiological neurohormonally‐mediate...
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| Veröffentlicht in: | ANZ journal of surgery 2018-01, Vol.88 (1-2), p.20-25 |
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| container_title | ANZ journal of surgery |
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| creator | Barreto, Savio G. Soenen, Stijn Chisholm, Jacob Chapman, Ian Kow, Lilian |
| description | Bariatric surgery is currently the most effective strategy for treating morbid obesity. Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow‐up. This review revisits a well‐established physiological neurohormonally‐mediated feedback loop, the so called ileal brake mechanism, with a special emphasis on the gut hormone peptide tyrosine tyrosine. The manuscript not only highlights the potential role of the ileal brake mechanism in weight loss and weight maintenance thereafter following obesity surgery, it also provides a compelling argument for using this appetite suppressing feedback loop to enable sustained long‐term weight loss in patients undergoing surgery for morbid obesity. |
| doi_str_mv | 10.1111/ans.14062 |
| format | Article |
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Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow‐up. This review revisits a well‐established physiological neurohormonally‐mediated feedback loop, the so called ileal brake mechanism, with a special emphasis on the gut hormone peptide tyrosine tyrosine. 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Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow‐up. This review revisits a well‐established physiological neurohormonally‐mediated feedback loop, the so called ileal brake mechanism, with a special emphasis on the gut hormone peptide tyrosine tyrosine. The manuscript not only highlights the potential role of the ileal brake mechanism in weight loss and weight maintenance thereafter following obesity surgery, it also provides a compelling argument for using this appetite suppressing feedback loop to enable sustained long‐term weight loss in patients undergoing surgery for morbid obesity.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>28593706</pmid><doi>10.1111/ans.14062</doi><tpages>6</tpages></addata></record> |
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| issn | 1445-1433 1445-2197 |
| language | eng |
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| source | Access via Wiley Online Library |
| subjects | Appetite appetite and food intake Body weight loss Brakes Feedback Feedback loops Gastrointestinal surgery gut hormones ileal brake Obesity obesity surgery Surgery Tyrosine Weight control Weight loss |
| title | Does the ileal brake mechanism contribute to sustained weight loss after bariatric surgery? |
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